Protein Alignment CG5096 and Lingo1

DIOPT Version :10

• Sequence 1: NP_723576.1
• Gene: CG5096 / 34410
• FlyBaseID: FBgn0032235
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_001094192.1
• Gene: Lingo1 / 315691
• RGDID: 1308668
• Length: 620
• Species: Rattus norvegicus
• Alignment Length: 358
• Identity: 85/358 - (23%)
• Similarity: 144/358 - (40%)
• Gaps: 84/358 - (23%)

  Fly    55 DTNLLDCSEKLQDWLSAEDW------EDL-TNGNVVFKTINLEHNNLTSVPILPKYDVENLYLAN 112
            :|.|||..:.....|:.:::      |:| .|.|:|........|||        :::..|.|.:
  Rat    72 ETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNL--------FNLRTLGLRS 128

  Fly   113 NQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLNLGYNDLHSL 177
            |::..|.:|.|..|:.|..||:|.|::   |::.|..        |:.|.|||:|.:|.|||..:
  Rat   129 NRLKLIPLGVFTGLSNLTKLDISENKI---VILLDYM--------FQDLYNLKSLEVGDNDLVYI 182

  Fly   178 DADLFEHIPHIEELVL--CS---------NSFH----------VIDQLSETAISGLQSLKILDVS 221
            ....|..:..:|:|.|  |:         :..|          .|:.:.:.:...|..||:|::|
  Rat   183 SHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEIS 247

  Fly   222 YME-IDDLPDTILHGPRDLEIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLT 285
            :.. :|.:....|:|.....:.|...||......|:::...|..|.|:.|||..:.| ::...|.
  Rat   248 HWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEG-SMLHELL 311

  Fly   286 KLTHLSMTFMSKLYKIGPGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVY 350
            :|..:.:. ..:|..:.|.||..|..|..|                  ||:|.|
  Rat   312 RLQEIQLV-GGQLAVVEPYAFRGLNYLRVL------------------NVSGNQ----------- 346

  Fly   351 LNNCNVSTLPKELLVRWDKLKALDLRFNPWNCD 383
                 ::||.:........|:.|.|..||..||
  Rat   347 -----LTTLEESAFHSVGNLETLILDSNPLACD 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR	54..>322	CDD:443914	72/295 (24%)
		leucine-rich repeat	85..104	CDD:275380	3/18 (17%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		leucine-rich repeat	129..163	CDD:275380	9/33 (27%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..214	CDD:275380	7/46 (15%)
		leucine-rich repeat	215..238	CDD:275380	7/23 (30%)
		leucine-rich repeat	239..261	CDD:275380	4/21 (19%)
		leucine-rich repeat	262..286	CDD:275380	8/23 (35%)
		leucine-rich repeat	287..311	CDD:275380	6/23 (26%)
		leucine-rich repeat	346..369	CDD:275380	2/22 (9%)
		leucine-rich repeat	370..388	CDD:275380	7/14 (50%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	1/2 (50%)
		LRR	71..>371	CDD:443914	82/353 (23%)
		leucine-rich repeat	73..96	CDD:275380	5/22 (23%)
		leucine-rich repeat	97..120	CDD:275380	8/30 (27%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		leucine-rich repeat	145..192	CDD:275380	18/57 (32%)
		leucine-rich repeat	193..216	CDD:275380	4/22 (18%)
		leucine-rich repeat	217..264	CDD:275380	9/46 (20%)
		leucine-rich repeat	265..288	CDD:275380	4/22 (18%)
		leucine-rich repeat	289..312	CDD:275380	8/23 (35%)
		leucine-rich repeat	313..336	CDD:275380	6/23 (26%)
		leucine-rich repeat	337..357	CDD:275380	8/53 (15%)
		PCC	341..>421	CDD:188093	13/50 (26%)
		IgI_Lingo-1	423..514	CDD:409561
		Ig strand A	423..426	CDD:409561
		Ig strand A'	431..435	CDD:409561
		Ig strand B	441..450	CDD:409561
		Ig strand C	455..460	CDD:409561
		Ig strand C'	463..465	CDD:409561
		Ig strand D	474..477	CDD:409561
		Ig strand E	480..487	CDD:409561
		Ig strand F	493..501	CDD:409561
		Ig strand G	504..514	CDD:409561