DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and Lrrc4b

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_937893.1	Gene:	Lrrc4b / 272381	MGIID:	3027390	Length:	709	Species:	Mus musculus

Alignment Length:	341	Identity:	85/341 - (24%)
Similarity:	141/341 - (41%)	Gaps:	92/341 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 CNCYIDTNLLDCSEKLQDWLSAEDWEDLTNGNVVFKTINLEHNNLTSVPILPKYD-------VEN 107
            |:|....:.:.|:.:       |..|...:..|..:.:||:.|::..:    :.|       :|.
Mouse    63 CSCSNQASRVICTRR-------ELAEVPASIPVNTRYLNLQENSIQVI----RTDTFKHLRHLEI 116

  Fly   108 LYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLNLGYN 172
            |.|:.|.:..|.||||..|..|.||:|..||||:   ||        .|.||.|..|:.|.|..|
Mouse   117 LQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT---VP--------TQAFEYLSKLRELWLRNN 170

  Fly   173 DLHSLDADLFEHIPHIEELVLCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPDTILHGPR 237
            .:.|:.:..|..:|.:..|.|  .....::.:||.|..||.:|:.|::....:.|:|
Mouse   171 PIESIPSYAFNRVPSLRRLDL--GELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIP-------- 225

  Fly   238 DLEIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKLYKIG 302
                                   |||:||                   :|..|.:: .::|..|.
Mouse   226 -----------------------NLTALV-------------------RLEELELS-GNRLDLIR 247

  Fly   303 PGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLVRW 367
            ||:|..|.||.:|.|...::.. |:..|..         |...||::.|::.|:.:||.:|....
Mouse   248 PGSFQGLTSLRKLWLMHAQVAT-IERNAFD---------DLKSLEELNLSHNNLMSLPHDLFTPL 302

  Fly   368 DKLKALDLRFNPWNCD 383
            .:|:.:.|..|||:|:
Mouse   303 HRLERVHLNHNPWHCN 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	78/315 (25%)
		leucine-rich repeat	85..104	CDD:275380	3/18 (17%)
		LRR_8	105..174	CDD:290566	28/68 (41%)
		leucine-rich repeat	105..128	CDD:275380	10/22 (45%)
		leucine-rich repeat	129..163	CDD:275380	14/33 (42%)
		LRR_8	163..222	CDD:290566	16/58 (28%)
		leucine-rich repeat	164..187	CDD:275380	6/22 (27%)
		leucine-rich repeat	188..214	CDD:275380	7/25 (28%)
		leucine-rich repeat	215..238	CDD:275380	4/22 (18%)
		leucine-rich repeat	239..261	CDD:275380	0/21 (0%)
		LRR_8	260..322	CDD:290566	17/61 (28%)
		leucine-rich repeat	262..286	CDD:275380	4/23 (17%)
		leucine-rich repeat	287..311	CDD:275380	8/23 (35%)
		leucine-rich repeat	346..369	CDD:275380	7/22 (32%)
		leucine-rich repeat	370..388	CDD:275380	6/14 (43%)
Lrrc4b	NP_937893.1	LRRNT	59..92	CDD:214470	6/35 (17%)
		LRR	<89..299	CDD:227223	72/287 (25%)
		LRR 1	89..110		4/24 (17%)
		leucine-rich repeat	90..113	CDD:275380	4/26 (15%)
		LRR 2	113..134		9/20 (45%)
		leucine-rich repeat	114..137	CDD:275380	10/22 (45%)
		LRR 3	137..158		12/31 (39%)
		leucine-rich repeat	138..161	CDD:275380	14/33 (42%)
		LRR 4	161..182		6/20 (30%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR 5	185..207		5/23 (22%)
		leucine-rich repeat	186..210	CDD:275380	7/25 (28%)
		LRR 6	210..231		7/51 (14%)
		leucine-rich repeat	211..232	CDD:275380	9/70 (13%)
		LRR 7	232..253		7/21 (33%)
		leucine-rich repeat	233..256	CDD:275380	8/23 (35%)
		LRR 8	256..277		6/30 (20%)
		leucine-rich repeat	257..280	CDD:275380	6/32 (19%)
		LRR 9	280..301		7/20 (35%)
		leucine-rich repeat	281..302	CDD:275380	7/20 (35%)
		LRRCT	313..363	CDD:214507	4/6 (67%)
		I-set	366..455	CDD:400151
		Ig strand A	366..369	CDD:409353
		Ig strand A'	373..376	CDD:409353
		Ig strand B	382..389	CDD:409353
		Ig strand C	395..400	CDD:409353
		Ig strand C'	403..405	CDD:409353
		Ig strand D	414..418	CDD:409353
		Ig strand E	421..425	CDD:409353
		Ig strand F	435..442	CDD:409353
		Ig strand G	445..455	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..552
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910