DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and Lingo2

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001159471.1	Gene:	Lingo2 / 242384	MGIID:	2442298	Length:	606	Species:	Mus musculus

Alignment Length:	412	Identity:	99/412 - (24%)
Similarity:	176/412 - (42%)	Gaps:	101/412 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 KKCNCY------------IDTNLLDCSEKLQDWLSAEDW------EDL-TNGNVVFKTINLE--- 90
            |..:|:            |:|.:||.|:.....::.|::      |:: .:.|::   .|:|
Mouse    39 KSVSCHRRRLLAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNII---ANVEPGA 100

  Fly    91 HNNLTSVPILPKYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTV 155
            .|||        :::.:|.|..|::..:.:|.|..|:.|..||:|.|::   |::.|..
Mouse   101 FNNL--------FNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKI---VILLDYM------ 148

  Fly   156 QDFESLENLKTLNLGYNDLHSLDADLFEHIPHIEELVL--CSNSFHVIDQLSETAISGLQSLKIL 218
              |:.|.|||:|.:|.|||..:....|..:..:|:|.|  |:     :..:...|:|.|:||..|
Mouse   149 --FQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCN-----LTAVPTEALSHLRSLIAL 206

  Fly   219 DVSYMEIDDLP----DTILHGPRDLEIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDN 279
            .:.::.|:::|    ..:.| .::||  |....|.:.:|....|..|||||.:....: :.:...
Mouse   207 HLKHLNINNMPVYAFKRLFH-LKNLE--IDYWPLLDLMPANSLYGLNLTSLSITNTNL-STVPFL 267

  Fly   280 VFPPLTKLTHLSMTFMSKLYKIGPGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYP 344
            .|..|..||||:::: :.:..|..|.||:|..|.||                  ::.|.|.....
Mouse   268 AFKHLVYLTHLNLSY-NPISTIEAGMFSDLIRLQEL------------------HIVGAQLRTIE 313

  Fly   345 P-----LEKVYLNNCNVS-----TLPKELLVRWDKLKALDLRFNPWNCDESNDFLINVLIDRINK 399
            |     |.  :|...|||     ||.:.:......|:.|.:..||..||....:|:        :
Mouse   314 PHSFQGLR--FLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWLL--------Q 368

  Fly   400 TTPVL---AKDVKCGGPNKLND 418
            ..|.|   .:...|.||:.:.:
Mouse   369 RQPNLQFGGQQPMCAGPDTIRE 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	82/334 (25%)
		leucine-rich repeat	85..104	CDD:275380	5/21 (24%)
		LRR_8	105..174	CDD:290566	21/68 (31%)
		leucine-rich repeat	105..128	CDD:275380	6/22 (27%)
		leucine-rich repeat	129..163	CDD:275380	9/33 (27%)
		LRR_8	163..222	CDD:290566	19/60 (32%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..214	CDD:275380	7/27 (26%)
		leucine-rich repeat	215..238	CDD:275380	5/26 (19%)
		leucine-rich repeat	239..261	CDD:275380	6/21 (29%)
		LRR_8	260..322	CDD:290566	19/61 (31%)
		leucine-rich repeat	262..286	CDD:275380	6/23 (26%)
		leucine-rich repeat	287..311	CDD:275380	9/23 (39%)
		leucine-rich repeat	346..369	CDD:275380	7/27 (26%)
		leucine-rich repeat	370..388	CDD:275380	6/17 (35%)
Lingo2	NP_001159471.1	LRRNT	27..60	CDD:214470	3/20 (15%)
		leucine-rich repeat	39..57	CDD:275380	2/17 (12%)
		LRR 1	58..79		5/20 (25%)
		leucine-rich repeat	59..82	CDD:275380	5/22 (23%)
		LRR_8	60..117	CDD:404697	14/67 (21%)
		LRR 2	82..103		4/23 (17%)
		leucine-rich repeat	83..106	CDD:275380	7/33 (21%)
		LRR_8	106..165	CDD:404697	21/69 (30%)
		LRR 3	106..127		5/20 (25%)
		leucine-rich repeat	107..130	CDD:275380	6/22 (27%)
		LRR 4	130..151		8/31 (26%)
		leucine-rich repeat	131..154	CDD:275380	9/33 (27%)
		LRR 5	154..175		9/20 (45%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		PPP1R42	176..>373	CDD:411060	56/234 (24%)
		LRR 6	178..199		5/25 (20%)
		leucine-rich repeat	179..202	CDD:275380	7/27 (26%)
		LRR 7	202..223		5/20 (25%)
		leucine-rich repeat	203..250	CDD:275380	11/49 (22%)
		LRR 8	226..247		6/23 (26%)
		LRR 9	250..271		6/21 (29%)
		leucine-rich repeat	251..274	CDD:275380	6/23 (26%)
		LRR 10	274..295		7/21 (33%)
		leucine-rich repeat	275..298	CDD:275380	9/23 (39%)
		LRR 11	298..319		6/38 (16%)
		leucine-rich repeat	299..322	CDD:275380	7/42 (17%)
		LRR 12	322..343		6/20 (30%)
		leucine-rich repeat	323..343	CDD:275380	6/19 (32%)
		LRRCT	355..408	CDD:214507	10/44 (23%)
		Ig	411..500	CDD:416386
		Ig strand A'	417..421	CDD:409353
		Ig strand B	427..436	CDD:409353
		Ig strand C	441..446	CDD:409353
		Ig strand C'	449..451	CDD:409353
		Ig strand D	460..463	CDD:409353
		Ig strand E	466..473	CDD:409353
		Ig strand F	479..487	CDD:409353
		Ig strand G	490..500	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910