DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and lron-8

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_491676.2	Gene:	lron-8 / 181983	WormBaseID:	WBGene00020693	Length:	341	Species:	Caenorhabditis elegans

Alignment Length:	264	Identity:	69/264 - (26%)
Similarity:	112/264 - (42%)	Gaps:	66/264 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NCYIDTNLLDCS--------EKLQDWLSAEDWE------DLTNGNVVFKTINLEHNNLTSVPILP 101
            :|..|.:.:.|.        :|.||:|..:...      |||: ::|...|||.|..|
Worm    21 SCRTDQHEMTCRGKNSLHDLKKDQDYLEVDTLNVHQAKLDLTD-DLVPDGINLSHLTL------- 77

  Fly   102 KYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKT 166
                  |...:|||..|....|..:..:..|.||.|:::..  .||         .|::||.||.
Worm    78 ------LNATDNQITRIGRRGFDKIRNMQFLYLSINQISHS--QPD---------PFQALEKLKR 125

  Fly   167 LNLGYNDLHSLDADLFEHIPHIEELVLCSNSF-HV---------IDQLSETAISGLQSLKILDVS 221
            |.:  ||  :||.::.|....:.......||| |:         |:.:......|:|.|:.|::|
Worm   126 LEM--ND--ALDGNMEEKSDMLRNFFHSKNSFVHLAQIELNKNKIEGIYPKTFCGIQGLQRLELS 186

  Fly   222 YMEID--DLPDTILHGPRDLEIFIAAGNLFNQLPKAL-KYATNLTSLVLNENPIE-------NLI 276
            ...|.  |...|.|   ::|:..:.||||..::|..: .:..:|:||.::.|||:       .|.
Worm   187 NNRIPSFDFARTCL---KELKALMLAGNLIQKIPADIWDFLPSLSSLDISNNPIDCDCATIRLLS 248

  Fly   277 GDNV 280
            ||:|
Worm   249 GDDV 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	63/238 (26%)
		leucine-rich repeat	85..104	CDD:275380	5/18 (28%)
		LRR_8	105..174	CDD:290566	19/68 (28%)
		leucine-rich repeat	105..128	CDD:275380	6/22 (27%)
		leucine-rich repeat	129..163	CDD:275380	8/33 (24%)
		LRR_8	163..222	CDD:290566	17/68 (25%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..214	CDD:275380	6/35 (17%)
		leucine-rich repeat	215..238	CDD:275380	7/24 (29%)
		leucine-rich repeat	239..261	CDD:275380	6/22 (27%)
		LRR_8	260..322	CDD:290566	10/28 (36%)
		leucine-rich repeat	262..286	CDD:275380	10/26 (38%)
		leucine-rich repeat	287..311	CDD:275380
		leucine-rich repeat	346..369	CDD:275380
		leucine-rich repeat	370..388	CDD:275380
lron-8	NP_491676.2	LRR	<71..>237	CDD:227223	51/196 (26%)
		leucine-rich repeat	75..98	CDD:275380	7/35 (20%)
		leucine-rich repeat	99..122	CDD:275380	8/33 (24%)
		leucine-rich repeat	123..158	CDD:275380	12/38 (32%)
		leucine-rich repeat	159..179	CDD:275380	2/19 (11%)
		leucine-rich repeat	180..202	CDD:275380	7/24 (29%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		LRRCT	235..282	CDD:214507	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930