DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5096 and let-4

DIOPT Version :9

Sequence 1:NP_723576.1 Gene:CG5096 / 34410 FlyBaseID:FBgn0032235 Length:491 Species:Drosophila melanogaster
Sequence 2:NP_510425.2 Gene:let-4 / 181554 WormBaseID:WBGene00002282 Length:773 Species:Caenorhabditis elegans


Alignment Length:406 Identity:96/406 - (23%)
Similarity:150/406 - (36%) Gaps:118/406 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 NVVFKTINLEHNNLTSVPI-----LP---KYDVEN-----------------LY---LANNQIDS 117
            |.|.:.:.|.||.:..||.     ||   :.|:.|                 ||   |.:|:|.|
 Worm   109 NPVLEEVVLNHNLIEKVPAAALAGLPNLLRLDLSNNSIVEIQEQEIFPNLNKLYDINLGSNKIFS 173

  Fly   118 ISVGAFQNL-TELVTLDLSHNRLTSKVLVP-DVFKGPFTVQ---------------DFESLENLK 165
            |....|||: ..:.|::|.||.:|:   || ...:|...:|               :|.:|..|.
 Worm   174 IHTSTFQNVKNSIQTINLGHNNMTA---VPSSAIRGLKQLQSLHLHKNRIEQLDALNFLNLPVLN 235

  Fly   166 TLNLGYNDLHSLDADLFEHIPHIEELVLCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPD 230
            .|||..|.:|.|:...|.::|.:..|.|..|.   |.:|:.......:.|::||::..||..:|.
 Worm   236 LLNLAGNQIHELNRQAFLNVPSLRYLYLSGNK---ITKLTAYQFQTFEQLEMLDLTNNEIGAIPA 297

  Fly   231 TILHGPRDLEIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFM 295
            ..|.|.:.|.                       .|.|..|.|.|                     
 Worm   298 NSLSGLKQLR-----------------------QLYLAHNKISN--------------------- 318

  Fly   296 SKLYKIGPGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLP 360
                 |...||:. .|:..|:||.|:|          |.:|.|.....|.|::|...:..:.|:.
 Worm   319 -----ISSNAFTN-SSIVVLVLSSNEL----------KTLTAGIISGLPNLQQVSFRDNQIKTIN 367

  Fly   361 KELLVRWDKLKALDLRFNPWNCDESNDFL--INVLIDRINKT----TPVLAKDVKCGGPNKLNDV 419
            :........|..|||..|.........||  :|:|:..:::.    ||..|.:.:. |...|.:.
 Worm   368 RNAFYDAASLVMLDLAKNQLTEIAPTTFLAQLNLLLVDLSENKLPKTPYSAFNSRV-GTVLLKEN 431

  Fly   420 TLLRVANEHMIESSTG 435
            .|:...|.||::..||
 Worm   432 PLVCTENLHMLQQGTG 447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5096NP_723576.1 LRR_RI 69..378 CDD:238064 80/341 (23%)
leucine-rich repeat 85..104 CDD:275380 7/26 (27%)
LRR_8 105..174 CDD:290566 27/105 (26%)
leucine-rich repeat 105..128 CDD:275380 11/43 (26%)
leucine-rich repeat 129..163 CDD:275380 11/49 (22%)
LRR_8 163..222 CDD:290566 17/58 (29%)
leucine-rich repeat 164..187 CDD:275380 8/22 (36%)
leucine-rich repeat 188..214 CDD:275380 5/25 (20%)
leucine-rich repeat 215..238 CDD:275380 8/22 (36%)
leucine-rich repeat 239..261 CDD:275380 1/21 (5%)
LRR_8 260..322 CDD:290566 13/61 (21%)
leucine-rich repeat 262..286 CDD:275380 5/23 (22%)
leucine-rich repeat 287..311 CDD:275380 3/23 (13%)
leucine-rich repeat 346..369 CDD:275380 3/22 (14%)
leucine-rich repeat 370..388 CDD:275380 5/17 (29%)
let-4NP_510425.2 leucine-rich repeat 66..86 CDD:275380
LRR_RI <71..275 CDD:238064 46/171 (27%)
LRR_8 88..146 CDD:290566 11/36 (31%)
leucine-rich repeat 88..111 CDD:275380 1/1 (100%)
leucine-rich repeat 112..135 CDD:275380 6/22 (27%)
leucine-rich repeat 136..160 CDD:275380 2/23 (9%)
LRR_8 156..220 CDD:290566 19/66 (29%)
leucine-rich repeat 161..184 CDD:275380 10/22 (45%)
leucine-rich repeat 186..209 CDD:275380 8/25 (32%)
leucine-rich repeat 210..257 CDD:275380 11/46 (24%)
LRR_RI <250..411 CDD:238064 46/223 (21%)
LRR_8 256..316 CDD:290566 18/85 (21%)
leucine-rich repeat 258..281 CDD:275380 5/25 (20%)
leucine-rich repeat 282..305 CDD:275380 8/22 (36%)
leucine-rich repeat 306..328 CDD:275380 9/71 (13%)
LRR_8 327..387 CDD:290566 18/69 (26%)
leucine-rich repeat 329..350 CDD:275380 8/30 (27%)
leucine-rich repeat 353..400 CDD:275380 10/46 (22%)
leucine-rich repeat 356..376 CDD:275380 2/19 (11%)
leucine-rich repeat 401..419 CDD:275380 3/17 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45617
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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