DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and Lrrn2

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_034862.1	Gene:	Lrrn2 / 16980	MGIID:	106037	Length:	730	Species:	Mus musculus

Alignment Length:	414	Identity:	108/414 - (26%)
Similarity:	179/414 - (43%)	Gaps:	87/414 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IFCIVLSQVSGQTKDETTTTETPKEKIKVIDSKL-C-KKCNC-----------YIDTNLLDCSEK 64
            :..::||.|:|      ||...|     |:..:: | .:|.|           |.:...:||::.
Mouse     5 VAALLLSWVAG------TTAAAP-----VVPWRVPCPPQCACQIRPWYTPRSSYREATTVDCNDL 58

  Fly    65 LQDWLSAEDWEDLTNGNVVFKTINLEHN--------------NLTSVPI---------------L 100
               :|:|.. ..|..|.   :|:.|:.|              |||.:.:               |
Mouse    59 ---FLTAVP-PRLPAGT---QTLLLQSNSISRIDQTELAYLANLTELDLSQNSFSDARDCDFQAL 116

  Fly   101 PKYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLK 165
            |:  :.:|:|..|:::.:...:|..||.|..|.|:||:|..  :.|..|.|         |.||.
Mouse   117 PQ--LLSLHLEENRLNRLEDHSFAGLTSLQELYLNHNQLCR--ISPRAFAG---------LGNLL 168

  Fly   166 TLNLGYNDLHSLDADLFEHIPHIEELVLCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPD 230
            .|:|..|.|.::|:..||.:|::|.|::..|....|..::...::.|:||.:..:|..||.|.
Mouse   169 RLHLNSNLLRTIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMSLREISDY-- 231

  Fly   231 TILHGPRDLEIFIAAGNLFNQLPK-ALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTF 294
             .|.|.:.||......|...|:|| ||:....|..|.||:||::. :|...|..:..|..|.:..
Mouse   232 -ALEGLQSLESLSFYDNQLAQVPKRALEQVPGLKFLDLNKNPLQR-VGPGDFANMLHLKELGLNN 294

  Fly   295 MSKLYKIGPGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTL 359
            |.:|..|...|...|..||:|.:::|..|:.|...|         :...|.:|.:.|||..:|.|
Mouse   295 MEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRA---------FHHLPQMETLMLNNNALSAL 350

  Fly   360 PKELLVRWDKLKALDLRFNPWNCD 383
            .::.:.....|:.:.|..||..||
Mouse   351 HQQTVESLPNLQEVGLHGNPIRCD 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	90/338 (27%)
		leucine-rich repeat	85..104	CDD:275380	8/47 (17%)
		LRR_8	105..174	CDD:290566	21/68 (31%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		leucine-rich repeat	129..163	CDD:275380	10/33 (30%)
		LRR_8	163..222	CDD:290566	17/58 (29%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..214	CDD:275380	5/25 (20%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..261	CDD:275380	8/22 (36%)
		LRR_8	260..322	CDD:290566	19/61 (31%)
		leucine-rich repeat	262..286	CDD:275380	8/23 (35%)
		leucine-rich repeat	287..311	CDD:275380	7/23 (30%)
		leucine-rich repeat	346..369	CDD:275380	6/22 (27%)
		leucine-rich repeat	370..388	CDD:275380	6/14 (43%)
Lrrn2	NP_034862.1	leucine-rich repeat	51..69	CDD:275380	5/21 (24%)
		LRR_RI	62..288	CDD:238064	66/246 (27%)
		leucine-rich repeat	71..94	CDD:275380	3/25 (12%)
		leucine-rich repeat	95..118	CDD:275380	3/22 (14%)
		LRR_8	117..177	CDD:290566	22/72 (31%)
		leucine-rich repeat	119..142	CDD:275380	5/22 (23%)
		leucine-rich repeat	143..166	CDD:275380	10/33 (30%)
		LRR_8	166..222	CDD:290566	17/55 (31%)
		leucine-rich repeat	167..190	CDD:275380	8/22 (36%)
		leucine-rich repeat	191..214	CDD:275380	4/22 (18%)
		LRR_RI	214..>372	CDD:238064	50/170 (29%)
		LRR_8	214..273	CDD:290566	22/61 (36%)
		leucine-rich repeat	215..238	CDD:275380	9/25 (36%)
		leucine-rich repeat	239..262	CDD:275380	8/22 (36%)
		leucine-rich repeat	263..286	CDD:275380	8/23 (35%)
		leucine-rich repeat	287..311	CDD:275380	7/23 (30%)
		LRR_8	310..371	CDD:290566	17/69 (25%)
		leucine-rich repeat	312..334	CDD:275380	7/30 (23%)
		leucine-rich repeat	337..360	CDD:275378	6/22 (27%)
		leucine-rich repeat	361..373	CDD:275378	4/11 (36%)
		TPKR_C2	369..412	CDD:301599	4/6 (67%)
		I-set	430..514	CDD:254352
		Ig	438..514	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910