DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and Gp5

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_032174.2	Gene:	Gp5 / 14729	MGIID:	1096363	Length:	567	Species:	Mus musculus

Alignment Length:	496	Identity:	117/496 - (23%)
Similarity:	190/496 - (38%)	Gaps:	146/496 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LEHNNLTSVPILPKYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNR--------LTSKVLV 145
            |.:::.:.:.:|     :.|.|:::.|.:|..|.|.:|.:|.||.|:.|:        |...||:
Mouse    65 LRNHSFSGMTVL-----QRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKISRLPRAILDKMVLL 124

  Fly   146 PDVFKGPFTVQD-----FESLENLKTLNLGYNDLHSLDADLFE----------------HIP--- 186
            ..:|.....::|     |:.|.||:.|.|..|.|..|.|:||.                |:|
Mouse   125 EQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLTHLPKGL 189

  Fly   187 -----HIEELVLCSNSFHVIDQLSETAISGLQS-LKILDVSYMEIDDLPDTILHGPRD----LEI 241
                 .:|:|:|.||....:|       |||.| |..|....:|.:.| .::..|..|    |..
Mouse   190 LGAQVKLEKLLLYSNQLTSVD-------SGLLSNLGALTELRLERNHL-RSVAPGAFDRLGNLSS 246

  Fly   242 FIAAGNLFNQLPKAL-KYATNLTSLVLNENPIENLIGDNVFPPLTKL-------THLS------- 291
            ...:|||...||.|| .:.::::.|.|.|||:|.| .|.:|..:..|       ||||
Mouse   247 LTLSGNLLESLPPALFLHVSSVSRLTLFENPLEEL-PDVLFGEMAGLRELWLNGTHLSTLPAAAF 310

  Fly   292 ----------MTFMSKLYKIGPGAFSELQSLTELILSDNKLLNEIDEEALS-------------- 332
                      :|...:|..:..|.|..|:.|..|.|..|.|. |:.::||.
Mouse   311 RNLSGLQTLGLTRNPRLSALPRGVFQGLRELRVLALHTNALA-ELRDDALRGLGHLRQVSLRHNR 374

  Fly   333 -KNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLVRWDKLKALDLRFNPWNCDESNDFLINVLIDR 396
             :.:....:.:...||.|.|.:..:.|||.::.....:|..:.|..|||.||..    :...:..
Mouse   375 LRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCG----LWPFLQW 435

  Fly   397 INKTTPVLAKD--VKCGGPNKLNDVTL-----------------LRVANEHMI------------ 430
            :.....:|.:|  .:|.||.....::.                 |....|:.:
Mouse   436 LRHHPDILGRDEPPQCRGPEPRASLSFWELLQGDPWCPDPRSLPLDPPTENALEAPVPSWLPNSW 500

  Fly   431 ------------ESSTGSLIWVGLLVVLLIAVPTIIGAYVM 459
                        ||....|.| ||.::||:| ..||.|:::
Mouse   501 QSQTWAQLVARGESPNNRLYW-GLYILLLVA-QAIIAAFIV 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	93/370 (25%)
		leucine-rich repeat	85..104	CDD:275380	2/14 (14%)
		LRR_8	105..174	CDD:290566	24/81 (30%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		leucine-rich repeat	129..163	CDD:275380	12/46 (26%)
		LRR_8	163..222	CDD:290566	24/83 (29%)
		leucine-rich repeat	164..187	CDD:275380	11/46 (24%)
		leucine-rich repeat	188..214	CDD:275380	9/25 (36%)
		leucine-rich repeat	215..238	CDD:275380	5/22 (23%)
		leucine-rich repeat	239..261	CDD:275380	8/22 (36%)
		LRR_8	260..322	CDD:290566	23/85 (27%)
		leucine-rich repeat	262..286	CDD:275380	9/23 (39%)
		leucine-rich repeat	287..311	CDD:275380	10/47 (21%)
		leucine-rich repeat	346..369	CDD:275380	7/22 (32%)
		leucine-rich repeat	370..388	CDD:275380	7/17 (41%)
Gp5	NP_032174.2	LRR 1	75..96		7/25 (28%)
		LRR_8	76..134	CDD:290566	17/62 (27%)
		leucine-rich repeat	76..99	CDD:275380	8/27 (30%)
		LRR 2	99..120		6/20 (30%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR 3	123..144		4/20 (20%)
		LRR_8	124..182	CDD:290566	14/57 (25%)
		leucine-rich repeat	124..147	CDD:275380	4/22 (18%)
		LRR_RI	126..402	CDD:238064	71/285 (25%)
		LRR 4	147..168		10/20 (50%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		LRR 5	171..193		2/21 (10%)
		leucine-rich repeat	172..195	CDD:275380	2/22 (9%)
		LRR_8	195..254	CDD:290566	19/66 (29%)
		LRR 6	195..216		9/27 (33%)
		leucine-rich repeat	196..219	CDD:275380	11/29 (38%)
		LRR 7	219..240		4/21 (19%)
		leucine-rich repeat	220..243	CDD:275380	5/23 (22%)
		LRR_8	243..302	CDD:290566	19/59 (32%)
		LRR 8	243..264		8/20 (40%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR 9	267..288		9/21 (43%)
		leucine-rich repeat	268..291	CDD:275380	9/23 (39%)
		LRR 10	291..312		5/20 (25%)
		leucine-rich repeat	292..315	CDD:275380	5/22 (23%)
		LRR_8	314..375	CDD:290566	13/61 (21%)
		LRR 11	315..337		4/21 (19%)
		leucine-rich repeat	316..338	CDD:275380	4/21 (19%)
		LRR 12	340..361		8/21 (38%)
		leucine-rich repeat	341..364	CDD:275380	8/23 (35%)
		LRR_8	364..422	CDD:290566	9/57 (16%)
		LRR 13	364..385		0/20 (0%)
		leucine-rich repeat	365..388	CDD:275380	0/22 (0%)
		LRR 14	388..409		7/20 (35%)
		leucine-rich repeat	389..410	CDD:275380	7/20 (35%)
		TPKR_C2	421..>454	CDD:301599	8/36 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910