DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and lrrn3a

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_005163128.1	Gene:	lrrn3a / 101887059	ZFINID:	ZDB-GENE-061220-7	Length:	691	Species:	Danio rerio

Alignment Length:	484	Identity:	109/484 - (22%)
Similarity:	199/484 - (41%)	Gaps:	136/484 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TTETPKEKIKVIDSKLCKKC---------NCYIDTNLLDCSE----KLQDWLSAEDWEDLTNGNV 82
            |......|..|:..||| ||         :.|.:...:||::    .|.:.|.::....|:..|.
Zfish    17 TNSVQASKWSVVCLKLC-KCEIRPWFSPLSMYNEAPTVDCNDLGLLTLPERLPSDTQVLLSQANS 80

  Fly    83 VFK------------TINLEHNNLTS-----VPILPKYDVENLYLANNQIDSIS---VGAFQNLT 127
            :.|            .::|..||::|     :..:|:  :.:|:|..|.:.|:.   :..|.||.
Zfish    81 IAKIDSPLDYLVNLTEVDLSRNNISSLSDIYIGHIPQ--LLSLHLEENWLSSLHDNFLAHFPNLQ 143

  Fly   128 ELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLNLGYNDLHSLDADLFEHIPHIEELV 192
            ||.   ::||.|:.           .:.:.|:.|..|..|:|..|.|.::.::.|:.:..:|.|:
Zfish   144 ELY---VNHNLLSL-----------ISAEAFQGLNKLLRLHLNSNQLRAIRSEWFQDLSQLEILM 194

  Fly   193 LCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPDTILHGPRDLEIFIAAGNLFNQLPK-AL 256
            :..|....|..::...:..|:||.:   :.|.:.::||:.|.|...||......|:|.::|: ||
Zfish   195 IGENPIARIQNMNFKPLINLRSLVL---TRMNLTEIPDSALVGLDKLESVSFYDNMFPKVPQAAL 256

  Fly   257 KYATNLTSLVLNENPIENL-------------IGDNVFPPLT-----------KLTHLSMTFMSK 297
            :...||..|.||:||||.:             :|.|..|.|.           :||.:..|...:
Zfish   257 RQVRNLKFLDLNKNPIERIQRGDFVDMIHLKELGINSMPELVSIDSFALHNLPELTKIEATNNPR 321

  Fly   298 LYKIGPGAFSELQSLTELILSDNKL--LNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLP 360
            |..|.|.|||:|..|..|:|:.|.|  |:.|..|:|            |.|::|.:::   :.:.
Zfish   322 LSYIHPNAFSQLPRLESLMLNSNALRALHHITVESL------------PNLQEVSIHS---NPIY 371

  Fly   361 KELLVRWDKLKALDLRFNPWNCDESNDFLINVLIDRINKTTPVLAKDVKCGGPN----------- 414
            .:.::||..:....:||          ..::.|:               |.||:
Zfish   372 CDCVIRWINMNNTRVRF----------MELDALL---------------CAGPSEFEGRLVKQVH 411

  Fly   415 --KLNDVTLLRVANEHM---IESSTGSLI 438
              ::.|:.|..::.|.:   :...||.|:
Zfish   412 SREMADICLPLISPESLPDQVNVGTGHLV 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	86/355 (24%)
		leucine-rich repeat	85..104	CDD:275380	6/35 (17%)
		LRR_8	105..174	CDD:290566	18/71 (25%)
		leucine-rich repeat	105..128	CDD:275380	7/25 (28%)
		leucine-rich repeat	129..163	CDD:275380	6/33 (18%)
		LRR_8	163..222	CDD:290566	13/58 (22%)
		leucine-rich repeat	164..187	CDD:275380	6/22 (27%)
		leucine-rich repeat	188..214	CDD:275380	5/25 (20%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		leucine-rich repeat	239..261	CDD:275380	7/22 (32%)
		LRR_8	260..322	CDD:290566	27/85 (32%)
		leucine-rich repeat	262..286	CDD:275380	12/47 (26%)
		leucine-rich repeat	287..311	CDD:275380	10/23 (43%)
		leucine-rich repeat	346..369	CDD:275380	4/22 (18%)
		leucine-rich repeat	370..388	CDD:275380	2/17 (12%)
lrrn3a	XP_005163128.1	LRR_RI	29..>272	CDD:238064	63/262 (24%)
		leucine-rich repeat	52..70	CDD:275380	4/17 (24%)
		leucine-rich repeat	71..93	CDD:275380	3/21 (14%)
		leucine-rich repeat	94..117	CDD:275380	4/22 (18%)
		leucine-rich repeat	118..141	CDD:275380	5/22 (23%)
		LRR_8	140..200	CDD:290566	18/73 (25%)
		leucine-rich repeat	142..165	CDD:275380	8/36 (22%)
		leucine-rich repeat	166..189	CDD:275380	6/22 (27%)
		leucine-rich repeat	190..213	CDD:275380	4/22 (18%)
		LRR_8	213..272	CDD:290566	21/61 (34%)
		leucine-rich repeat	214..237	CDD:275380	8/25 (32%)
		leucine-rich repeat	238..261	CDD:275380	7/22 (32%)
		leucine-rich repeat	262..285	CDD:275380	8/22 (36%)
		leucine-rich repeat	286..310	CDD:275380	4/23 (17%)
		LRR_8	309..370	CDD:290566	22/75 (29%)
		leucine-rich repeat	311..333	CDD:275380	9/21 (43%)
		leucine-rich repeat	336..359	CDD:275378	9/34 (26%)
		leucine-rich repeat	360..372	CDD:275378	2/14 (14%)
		LRRCT	368..412	CDD:214507	8/68 (12%)
		IG_like	429..513	CDD:214653	3/12 (25%)
		Ig	437..513	CDD:299845	2/4 (50%)
		FN3	526..>591	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910