DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and chad

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_017953398.1	Gene:	chad / 101732210	XenbaseID:	XB-GENE-957654	Length:	360	Species:	Xenopus tropicalis

Alignment Length:	277	Identity:	73/277 - (26%)
Similarity:	107/277 - (38%)	Gaps:	78/277 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 LYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLNLGYN 172
            |||:||:|..:..|||..|:||..|.:.||::.      |:.||.|:     .|.||..|.||.|
Frog   105 LYLSNNEISVLGTGAFDELSELTYLYMDHNKII------DLPKGLFS-----PLFNLFILQLGNN 158

  Fly   173 DLHSLDADLFEHIPHIEELVLCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPDTILHGPR 237
            .:..|.|..|                           :|.:.|:.|.:|..||.::....|....
Frog   159 KVRDLKAATF---------------------------TGAKDLRWLYLSDNEITNMQPGSLDEVE 196

  Fly   238 DLEIFIAAGNLFNQLP-KALKYATNLTSLVLNENPIENLIGDNVFPPLTK-LTHLSMTFMSKLYK 300
            :|.||...||..:..| .|:.....:..|.::.|||: :|.|..|....: :..|||..|. :.|
Frog   197 NLAIFHMDGNQLSSYPLAAISKLRVVEDLKISRNPIK-IIPDFAFQSFGRYMESLSMENMG-VEK 259

  Fly   301 IGPGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLV 365
            ....||..:.:|..|.:..|||                                  |.||..  |
Frog   260 FSDKAFVGVTTLKTLNIEGNKL----------------------------------SQLPAN--V 288

  Fly   366 RWDKLKALDLRFNPWNC 382
            .:..|::|.|..|||:|
Frog   289 PYSSLQSLALANNPWHC 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	69/271 (25%)
		leucine-rich repeat	85..104	CDD:275380
		LRR_8	105..174	CDD:290566	26/65 (40%)
		leucine-rich repeat	105..128	CDD:275380	10/19 (53%)
		leucine-rich repeat	129..163	CDD:275380	9/33 (27%)
		LRR_8	163..222	CDD:290566	12/58 (21%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..214	CDD:275380	1/25 (4%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		leucine-rich repeat	239..261	CDD:275380	7/22 (32%)
		LRR_8	260..322	CDD:290566	17/62 (27%)
		leucine-rich repeat	262..286	CDD:275380	7/23 (30%)
		leucine-rich repeat	287..311	CDD:275380	7/23 (30%)
		leucine-rich repeat	346..369	CDD:275380	4/22 (18%)
		leucine-rich repeat	370..388	CDD:275380	7/13 (54%)
chad	XP_017953398.1	LRRNT	22..>50	CDD:214470
		leucine-rich repeat	54..77	CDD:275380
		LRR_8	77..136	CDD:338972	15/30 (50%)
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380	10/19 (53%)
		LRR	<105..>302	CDD:227223	69/272 (25%)
		leucine-rich repeat	126..149	CDD:275380	9/33 (27%)
		leucine-rich repeat	150..173	CDD:275380	9/49 (18%)
		leucine-rich repeat	174..197	CDD:275380	6/22 (27%)
		leucine-rich repeat	198..221	CDD:275380	7/22 (32%)
		leucine-rich repeat	222..245	CDD:275380	7/23 (30%)
		leucine-rich repeat	247..270	CDD:275380	7/23 (30%)
		LRRCT	301..348	CDD:214507	4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D334557at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920