DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and XB5838993

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_002934278.1	Gene:	XB5838993 / 100488097	XenbaseID:	XB-GENE-5838994	Length:	660	Species:	Xenopus tropicalis

Alignment Length:	474	Identity:	115/474 - (24%)
Similarity:	186/474 - (39%)	Gaps:	117/474 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTKSATLAAAIFCIVLSQVSGQTKDETTTTETPKEKIKVIDSKLCKKCNCY-IDTNLLDCSEKLQ 66
            |.:..|:......|:|............||:.|            :.|.|. :..::| |..
Frog    27 LLRQITMRCLHLLILLLAFDNLVSTIPATTQCP------------ENCTCLPLQQHVL-CGN--- 75

  Fly    67 DWLSAEDWEDLTN--GNVVFKTINLE-HNNLTS------VPILPKYDVENLYLANNQIDSISVGA 122
                    ..||:  .||...|:.|. .|||.|      :..||  ::..|||:|.:||:|...|
Frog    76 --------ASLTSVPSNVPNNTVELHLQNNLFSELHDSFLQDLP--ELRGLYLSNCEIDTIKPEA 130

  Fly   123 FQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLNLGYNDLHSLDADLFEHIPH 187
            ||.:|.:..|.|..|.|           |......|.:|.:|..|:|..|.:.|:...||..:..
Frog   131 FQKVTSIKYLHLDRNHL-----------GDLQEGTFRNLSSLIYLHLESNQITSIREGLFAPLEK 184

  Fly   188 IEELVLCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPDTILHGPRDLEIFIAAGNL---- 248
            :..|.|.:|   ::.:|::.:::||..|:.||:.:..:..:.:         :.|.|..||
Frog   185 LSALYLSNN---LLQELTDGSLNGLTQLRWLDLGFNMLSKISN---------QSFTAIANLRKLN 237

  Fly   249 -----FNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKLYKIGPGAFSE 308
                 ...:|.|::..|.|..|.|:.|.|:.|...:....|..:|.|.:..: :|.|:....||:
Frog   238 LERNNLTSIPSAIRRRTGLQMLRLSGNSIKKLSSSSFGRSLRFITELYLDSL-RLEKVTSMTFSK 301

  Fly   309 LQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLVRWDKLKAL 373
            |:.|..|.||:|.|      ::||                ||    ||....|           :
Frog   302 LRMLKVLDLSNNSL------QSLS----------------VY----NVKIFTK-----------I 329

  Fly   374 DLRFNPWNCDESNDFLINVLIDRINKTTPVLA-KDVKCGGPNKLNDVTLLRVANEHMIESSTGSL 437
            .|..|||.||.|   ||. |..|:.:|..:.| :...|..|..|...:|:.|....:...:||..
Frog   330 YLTGNPWRCDCS---LIG-LHTRLQQTKNLDAEQQAHCDAPKALKGQSLINVNLLKLTCPATGED 390

  Fly   438 IWVGLLVVLLIAVPTIIGA 456
            |.|      ..:.|:::|:
Frog   391 ISV------TASTPSLLGS 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	81/326 (25%)
		leucine-rich repeat	85..104	CDD:275380	8/25 (32%)
		LRR_8	105..174	CDD:290566	22/68 (32%)
		leucine-rich repeat	105..128	CDD:275380	10/22 (45%)
		leucine-rich repeat	129..163	CDD:275380	7/33 (21%)
		LRR_8	163..222	CDD:290566	16/58 (28%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		leucine-rich repeat	188..214	CDD:275380	6/25 (24%)
		leucine-rich repeat	215..238	CDD:275380	3/22 (14%)
		leucine-rich repeat	239..261	CDD:275380	6/30 (20%)
		LRR_8	260..322	CDD:290566	20/61 (33%)
		leucine-rich repeat	262..286	CDD:275380	7/23 (30%)
		leucine-rich repeat	287..311	CDD:275380	7/23 (30%)
		leucine-rich repeat	346..369	CDD:275380	5/22 (23%)
		leucine-rich repeat	370..388	CDD:275380	7/17 (41%)
XB5838993	XP_002934278.1	LRRNT	57..91	CDD:214470	10/57 (18%)
		LRR_8	91..147	CDD:338972	21/57 (37%)
		leucine-rich repeat	91..112	CDD:275380	7/22 (32%)
		leucine-rich repeat	113..136	CDD:275380	10/22 (45%)
		LRR_8	136..195	CDD:338972	17/72 (24%)
		leucine-rich repeat	137..160	CDD:275380	7/33 (21%)
		LRR	138..437	CDD:227223	81/337 (24%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		leucine-rich repeat	185..208	CDD:275380	6/25 (24%)
		leucine-rich repeat	209..232	CDD:275380	5/31 (16%)
		leucine-rich repeat	233..255	CDD:275380	3/21 (14%)
		leucine-rich repeat	256..280	CDD:275380	7/23 (30%)
		leucine-rich repeat	281..304	CDD:275380	7/23 (30%)
		fn3	456..524	CDD:365830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910