DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and si:ch211-180f4.1

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001373634.1	Gene:	si:ch211-180f4.1 / 100144405	ZFINID:	ZDB-GENE-080327-27	Length:	744	Species:	Danio rerio

Alignment Length:	473	Identity:	115/473 - (24%)
Similarity:	192/473 - (40%)	Gaps:	98/473 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTKSATLAAAIFCIVLSQVSGQTKDETTTTETPK---EKIKVIDSKLCKKC-------NCYIDT- 56
            ||....||.....:.:.....|...||....||:   .:.|.:|   |.:.       |..:||
Zfish    11 LTVCLVLAVCRCSLAVPFCPAQCVCETRPWYTPQSVYHQAKTVD---CNELHLSRIPWNISVDTQ 72

  Fly    57 -------NLLDCSEKLQDWLSAEDWEDLTNGNVVFKTINLEHNNLTSVPILPKYDVENLYLANNQ 114
                   |:...:.:||..::..:.:...|.......:.|  ||||        .:..|||..||
Zfish    73 VLLLQSNNISRGTSQLQSLVNLTELDLSQNHFTQIHDVGL--NNLT--------QLVTLYLEENQ 127

  Fly   115 IDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLNLGYNDLHSLDA 179
            |..:.....::|..|..|.::||:::|  :.|:.|.|         |.||..|:|..|.|.::|:
Zfish   128 IKELPDMCLKDLVSLEELYINHNQISS--IGPNAFSG---------LGNLLRLHLNSNKLVAIDS 181

  Fly   180 DLFEHIPHIEELVLCSN--------SFHVIDQLSETAISGLQSLKILDVSYMEIDDLPDTILHGP 236
            ..||.:|::|.|::..|        :||.:.:|....::|           |.:.::|:....|.
Zfish   182 HWFESLPNLEILMIGENPILGLQDMNFHPLTKLHSLVLAG-----------MGLREIPEGAFQGL 235

  Fly   237 RDLEIFIAAGNLFNQLP-KALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKLYK 300
            ..||......|....:| |||:...:|..|.||:|||.. |.:..|.....|..||:..|.:|..
Zfish   236 EYLESLSFFDNKLTAVPKKALRVLPSLKFLDLNKNPIVR-IQEGDFQDFPHLEELSLNNMEELVA 299

  Fly   301 IGPGAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLV 365
            :..|:||.|..:.:|.|.:|..|..||..|         :|....|..:.::|.:::.||.|::.
Zfish   300 VERGSFSNLPQMAKLELYNNPHLFFIDRAA---------FLKMRGLRTLLIHNNDLTLLPHEIVS 355

  Fly   366 RWDKLKALDLRFNPWNCDESNDFLINVLIDRINKTTPVLAKDVKCGGPNKLN----DVTLLRVAN 426
            .:..|..:.|..||..|            |.:|...|||      |..:.|.    .:||. .:.
Zfish   356 AFPNLDEISLHSNPLRC------------DCLNNWGPVL------GNQSSLKVLEPQITLC-ASP 401

  Fly   427 EHMIESSTGSLI---WVG 441
            :|::..:...::   |.|
Zfish   402 QHLVGQALQDVVSASWNG 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	82/317 (26%)
		leucine-rich repeat	85..104	CDD:275380	5/18 (28%)
		LRR_8	105..174	CDD:290566	21/68 (31%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		leucine-rich repeat	129..163	CDD:275380	9/33 (27%)
		LRR_8	163..222	CDD:290566	17/66 (26%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..214	CDD:275380	7/33 (21%)
		leucine-rich repeat	215..238	CDD:275380	3/22 (14%)
		leucine-rich repeat	239..261	CDD:275380	7/22 (32%)
		LRR_8	260..322	CDD:290566	21/61 (34%)
		leucine-rich repeat	262..286	CDD:275380	9/23 (39%)
		leucine-rich repeat	287..311	CDD:275380	9/23 (39%)
		leucine-rich repeat	346..369	CDD:275380	5/22 (23%)
		leucine-rich repeat	370..388	CDD:275380	5/17 (29%)
si:ch211-180f4.1	NP_001373634.1	leucine-rich repeat	51..70	CDD:275380	4/21 (19%)
		PPP1R42	55..266	CDD:411060	57/242 (24%)
		leucine-rich repeat	71..93	CDD:275380	4/21 (19%)
		leucine-rich repeat	94..117	CDD:275380	6/32 (19%)
		leucine-rich repeat	118..141	CDD:275380	7/22 (32%)
		leucine-rich repeat	142..165	CDD:275380	9/33 (27%)
		leucine-rich repeat	166..189	CDD:275380	8/22 (36%)
		leucine-rich repeat	190..213	CDD:275380	5/22 (23%)
		leucine-rich repeat	214..237	CDD:275380	5/33 (15%)
		leucine-rich repeat	238..261	CDD:275380	7/22 (32%)
		LRR_8	260..320	CDD:404697	20/60 (33%)
		leucine-rich repeat	262..285	CDD:275380	9/23 (39%)
		leucine-rich repeat	286..310	CDD:275380	9/23 (39%)
		leucine-rich repeat	311..330	CDD:275380	7/27 (26%)
		leucine-rich repeat	336..359	CDD:275378	5/22 (23%)
		PCC	341..>412	CDD:188093	19/89 (21%)
		leucine-rich repeat	360..372	CDD:275378	4/11 (36%)
		IG	434..528	CDD:214652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910