DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and lingo1

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001093719.1	Gene:	lingo1 / 100101739	XenbaseID:	XB-GENE-921957	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	413	Identity:	107/413 - (25%)
Similarity:	171/413 - (41%)	Gaps:	83/413 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLTKSATLAAAIFCIVLSQVSGQTKDETTTTE-TPKEKIKVIDSKLCKKCNCYI--------DT 56
            |.|...:.|...:..:|.|.:||.........: :|:::     |.||.: ..|:        ||
Frog     1 MILQLPSCLCPILLIVVGSILSGSASGCPQRCDCSPQDR-----SVLCHR-KRYLDVPEGIPTDT 59

  Fly    57 NLLDCSEKL-----QDWLSAEDW-EDL-TNGNVVFKTINLEHNNLTSVPILPKYDVENLYLANNQ 114
            .|||.|:..     ||..||..: |:| .|.|:|........|.|        :::.:|.|.:|:
Frog    60 RLLDLSKNRIKALNQDEFSAFPYLEELELNENIVSIIEPGAFNGL--------FNLRSLGLRSNR 116

  Fly   115 IDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLENLKTLNLGYNDLHSLDA 179
            :..|.:|.|..|:.|..||:|.|::.  :|:.|:         |:.|.|||:|.:|.|||..:..
Frog   117 LKLIPLGVFTGLSNLTQLDISENKIV--ILLDDM---------FQDLYNLKSLEVGDNDLVYISH 170

  Fly   180 DLFEHIPHIEELVL--CSNSFHVIDQLSETAISGLQSLKILDVSYMEIDDLPD---TILHGPRDL 239
            ..|..:..:|||.|  |:     :..:...|:|.|..|..|.:.|:.|:.:.|   ..|:..::|
Frog   171 RAFRGLNSLEELTLEKCN-----LTSVPTEALSHLHGLITLKLRYLNINVIRDYSFKRLYRLKNL 230

  Fly   240 EIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHL-SMTFMSKLYKIGP 303
            |  ||.....:.:.....|..|||||.:..:.:.::       |...:.|| .:.|::..|  .|
Frog   231 E--IAHWPYLDTMTSNGLYGLNLTSLSITHSNLSSI-------PYVAIRHLVYLRFLNLSY--NP 284

  Fly   304 GAFSELQSLTELILSDNKLLNEIDEEALSKNVTGGQYLDYPPLEKVYLNNCNV--------STLP 360
            ....|...|.||:     .|.|.       ::.|||.....|.....||:..|        |||.
Frog   285 ITAVEGSMLYELL-----RLQEF-------HLVGGQLSVVEPYAFRGLNHLKVLNVSSNYLSTLE 337

  Fly   361 KELLVRWDKLKALDLRFNPWNCD 383
            :........|:.|.|..||..||
Frog   338 ESSFHSVGNLETLILDKNPLACD 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	83/324 (26%)
		leucine-rich repeat	85..104	CDD:275380	2/18 (11%)
		LRR_8	105..174	CDD:290566	22/68 (32%)
		leucine-rich repeat	105..128	CDD:275380	7/22 (32%)
		leucine-rich repeat	129..163	CDD:275380	9/33 (27%)
		LRR_8	163..222	CDD:290566	19/60 (32%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..214	CDD:275380	8/27 (30%)
		leucine-rich repeat	215..238	CDD:275380	6/25 (24%)
		leucine-rich repeat	239..261	CDD:275380	5/21 (24%)
		LRR_8	260..322	CDD:290566	15/62 (24%)
		leucine-rich repeat	262..286	CDD:275380	5/23 (22%)
		leucine-rich repeat	287..311	CDD:275380	6/24 (25%)
		leucine-rich repeat	346..369	CDD:275380	6/30 (20%)
		leucine-rich repeat	370..388	CDD:275380	7/14 (50%)
lingo1	NP_001093719.1	LRRNT	27..61	CDD:214470	7/39 (18%)
		LRR 1	58..79		8/20 (40%)
		leucine-rich repeat	59..82	CDD:275380	9/22 (41%)
		PLN00113	62..>381	CDD:215061	92/346 (27%)
		LRR 2	82..103		5/20 (25%)
		leucine-rich repeat	83..106	CDD:275380	7/30 (23%)
		LRR_8	106..165	CDD:338972	22/69 (32%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 4	130..151		8/31 (26%)
		leucine-rich repeat	131..154	CDD:275380	9/33 (27%)
		LRR 5	154..175		9/20 (45%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		LRR 6	178..199		6/25 (24%)
		leucine-rich repeat	179..250	CDD:275380	19/77 (25%)
		LRR 7	202..223		5/20 (25%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		LRR 8	250..271		6/27 (22%)
		leucine-rich repeat	251..274	CDD:275380	7/29 (24%)
		LRR 9	274..295		5/22 (23%)
		leucine-rich repeat	275..298	CDD:275380	7/29 (24%)
		LRR 10	298..319		6/27 (22%)
		leucine-rich repeat	299..322	CDD:275380	7/29 (24%)
		LRR 11	322..343		4/20 (20%)
		leucine-rich repeat	323..343	CDD:275380	4/19 (21%)
		Ig	425..500	CDD:386229
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910