Protein Alignment CG5096 and slit1

DIOPT Version :10

• Sequence 1: NP_723576.1
• Gene: CG5096 / 34410
• FlyBaseID: FBgn0032235
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_001090702.1
• Gene: slit1 / 100036682
• XenbaseID: XB-GENE-1007728
• Length: 1529
• Species: Xenopus tropicalis
• Alignment Length: 541
• Identity: 117/541 - (21%)
• Similarity: 193/541 - (35%)
• Gaps: 173/541 - (31%)

  Fly    22 SGQTKDETTTTETPKEKIKVIDSKLC-KKCNCYIDTNLLDCSEKLQDWLSAEDWEDLTNGNVVFK 85
            |||       ::.|..:|..:....| ..|.|  ...::||..|....:.|...|.:|.
 Frog   263 SGQ-------SDPPSSQICSLSIGSCPAMCTC--SNGIVDCRGKGLTAIPANLPETMTE------ 312

  Fly    86 TINLEHNNLTSVP---ILPKYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPD 147
             |.||.|.:.|||   ..|...:..:.|:||||..|:..|||.|..|.:|.|..|::|.  |...
 Frog   313 -IRLELNGIKSVPPGAFSPYKKLRRIDLSNNQISEIAPDAFQGLRSLNSLVLYGNKITD--LPKG 374

  Fly   148 VFKGPFTVQ---------------DFESLENLKTLNLGYNDLHSLDADLFEHIPHIEELVLCSNS 197
            ||.|...:|               .|:.|:||..|:|..|.:.||....|..:..|:.|.|..|.
 Frog   375 VFSGLHALQLLLLNANKINCIRADTFQDLQNLSLLSLYDNKIQSLAKGTFAALRAIQTLHLAQNP 439

  Fly   198 FHVID--------------------------QLSETAISGLQSLK-------------------- 216
            | :.|                          :|:...|..::|.|
 Frog   440 F-ICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLN 503

  Fly   217 ------------------ILDVSYMEIDDLPDTILHGPRDLEI------FIAAGNLFNQLPKALK 257
                              ::|.|.:::..:||.|.....:|.:      .:.|..||.:||
 Frog   504 SECNSDVVCPPKCRCESNVVDCSNLKLTKIPDRIPQSTAELRLNNNEIATLEATGLFRKLP---- 564

  Fly   258 YATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSMTFMSKLYKIGPGAFSELQSLTELILSDNKL 322
               :|..:.|:.|.|.. |.|..|.....::.|.:| .:.|..:..|.|..|:.|..|:|.:|:
 Frog   565 ---HLKKINLSNNKISE-IEDAAFEGAASVSELHLT-ANHLESVRSGMFRGLEGLRTLMLRNNR- 623

  Fly   323 LNEIDEEALS--KNVTGGQYLDYPPLEKVYLNNCNVSTLPKELLVRWDKLKALDLRFNPWNCD-- 383
            ::.:..::.:  :||.         |..:|.|  .:||:..........|..|:|..||:||:
 Frog   624 VSCVHNDSFTGLRNVR---------LLSLYDN--QISTITPGAFDTLQSLSTLNLLANPFNCNCQ 677

  Fly   384 --------------------ESNDFLINVLIDRINKTTPVLAKDVKC-GGPNKLNDV-------- 419
                                ::.|||..:.:.      .|...|.:| .|..:|:..
 Frog   678 LAWLGDWLRKRKIVTGNPRCQNPDFLRQIPLQ------DVAFPDFRCEDGQEELSCAPQPQCPQE 736

  Fly   420 -----TLLRVANEHMIESSTG 435
                 |::|.:|:|::....|
 Frog   737 CTCLDTVVRCSNKHLLSLPKG 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR	54..>322	CDD:443914	82/355 (23%)
		leucine-rich repeat	85..104	CDD:275380	8/21 (38%)
		leucine-rich repeat	105..128	CDD:275380	10/22 (45%)
		leucine-rich repeat	129..163	CDD:275380	12/48 (25%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		leucine-rich repeat	188..214	CDD:275380	8/51 (16%)
		leucine-rich repeat	215..238	CDD:275380	6/60 (10%)
		leucine-rich repeat	239..261	CDD:275380	6/27 (22%)
		leucine-rich repeat	262..286	CDD:275380	7/23 (30%)
		leucine-rich repeat	287..311	CDD:275380	6/23 (26%)
		leucine-rich repeat	346..369	CDD:275380	5/22 (23%)
		leucine-rich repeat	370..388	CDD:275380	7/39 (18%)
slit1	NP_001090702.1	LRR	<42..>216	CDD:443914
		leucine-rich repeat	42..61	CDD:275380
		leucine-rich repeat	62..85	CDD:275380
		leucine-rich repeat	86..109	CDD:275380
		leucine-rich repeat	110..133	CDD:275380
		leucine-rich repeat	134..157	CDD:275380
		leucine-rich repeat	158..181	CDD:275380
		leucine-rich repeat	182..205	CDD:275380
		PCC	187..>249	CDD:188093
		leucine-rich repeat	206..310	CDD:275380	13/55 (24%)
		LRR	<271..>460	CDD:443914	54/200 (27%)
		leucine-rich repeat	312..333	CDD:275380	8/27 (30%)
		leucine-rich repeat	334..357	CDD:275380	10/22 (45%)
		leucine-rich repeat	358..378	CDD:275380	8/21 (38%)
		leucine-rich repeat	406..429	CDD:275380	7/22 (32%)
		LRRNT	512..538	CDD:396168	4/25 (16%)
		leucine-rich repeat	522..540	CDD:275380	5/17 (29%)
		LRR	526..>910	CDD:443914	54/259 (21%)
		leucine-rich repeat	541..565	CDD:275380	6/30 (20%)
		leucine-rich repeat	566..589	CDD:275380	7/23 (30%)
		leucine-rich repeat	590..613	CDD:275380	6/23 (26%)
		leucine-rich repeat	614..637	CDD:275380	4/23 (17%)
		leucine-rich repeat	638..661	CDD:275380	6/33 (18%)
		leucine-rich repeat	662..784	CDD:275380	20/102 (20%)
		leucine-rich repeat	663..753	CDD:275380	18/95 (19%)
		LRRNT	732..764	CDD:214470	5/26 (19%)
		leucine-rich repeat	785..808	CDD:275380
		leucine-rich repeat	809..832	CDD:275380
		leucine-rich repeat	833..853	CDD:275380
		EGF_CA	926..961	CDD:238011
		EGF_CA	1003..1039	CDD:238011
		EGF_CA	1042..1078	CDD:238011
		EGF_CA	1083..1117	CDD:238011
		EGF_CA	<1130..1158	CDD:238011
		LamG	1184..1317	CDD:214598