DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5096 and lingo4a

DIOPT Version :9

Sequence 1:	NP_723576.1	Gene:	CG5096 / 34410	FlyBaseID:	FBgn0032235	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001076447.1	Gene:	lingo4a / 100005227	ZFINID:	ZDB-GENE-060503-275	Length:	618	Species:	Danio rerio

Alignment Length:	441	Identity:	116/441 - (26%)
Similarity:	180/441 - (40%)	Gaps:	107/441 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IKVIDSKLC-KKCNCYIDTNLLDCSEKLQDWLSA--EDWEDLTNGNVVFKTINLEHNN---LTSV 97
            :.|..|..| ::|:|.....|:|||.:   .|||  |...|.|      :.:||.:|:   |:|.
Zfish    34 VGVATSGPCAQRCDCSPKLPLVDCSSQ---QLSAVPEGVPDAT------QVLNLTYNHLKTLSSR 89

  Fly    98 PILPKYDVENLYLANNQIDSISVGAFQNLTELVTLDLSHNRLTSKVLVPDVFKGPFTVQDFESLE 162
            .......:..|.|:.|.:..|.|.||..|..|:||.||.|||.   ::|        |..|..|.
Zfish    90 QFFSLRQLRELDLSANMLTVIEVEAFVGLQNLITLRLSRNRLK---IIP--------VGAFSGLP 143

  Fly   163 NLKTLNLGYNDLHSLDADLFEHIPHIEELVLCSNSFHVIDQLSETAISGLQSLKILDVSYMEIDD 227
            |::.|::..|::..|..|:|..:|.:::|....|....|   |..|.|||.:|
Zfish   144 NVQFLDISENEILVLLDDMFGEMPSLQKLEASENDLVFI---SNRAFSGLPNL------------ 193

  Fly   228 LPDTILHGPRDLEIFIAAGNLFNQLPKALKYATNLTSLVLNENPIENLIGDNVFPPLTKLTHLSM 292
                       ||:         :|.:.     |||::     |.|      .|..||.|.||..
Zfish   194 -----------LEL---------RLERC-----NLTTV-----PSE------AFSRLTGLQHLRF 222

  Fly   293 TFMSKLYKIGPGAFSELQSLTELILSDNKLLNEIDEEAL-SKNVTGGQYLDYPPLEKVYLNNCNV 356
            ..:. |..:...:|.:||.|.:|.:|....|:.:...:| ..|:|           .:.|::||:
Zfish   223 CRLG-LTALPNNSFRQLQRLQDLHVSRCPWLHTLAVNSLIGLNLT-----------SLTLSHCNL 275

  Fly   357 STLPKELLVRWDKLKALDLRFNPWNCDESNDFLINVLID--RINK----TTPVLAKDVKCGGPNK 415
            |.:|...|.....|:.|||.:||     ....|..:|.|  |:.:    :|.:|  .|:.|....
Zfish   276 SAVPYAPLHHLVYLRYLDLSYNP-----ITTVLSGLLGDLLRLQELHLVSTGLL--HVESGAFRN 333

  Fly   416 LNDVTLLRVANEHMIESSTGSLIWVGLLVVL-LIAVPTIIGA---YVMKRR 462
            |....||.|::..::.....:...||.|.|| |...|.....   :||:||
Zfish   334 LAFFRLLNVSDNRLVTLEESAFHAVGSLEVLRLDGNPLACDCRLLWVMRRR 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5096	NP_723576.1	LRR_RI	69..378	CDD:238064	82/314 (26%)
		leucine-rich repeat	85..104	CDD:275380	5/21 (24%)
		LRR_8	105..174	CDD:290566	23/68 (34%)
		leucine-rich repeat	105..128	CDD:275380	8/22 (36%)
		leucine-rich repeat	129..163	CDD:275380	12/33 (36%)
		LRR_8	163..222	CDD:290566	16/58 (28%)
		leucine-rich repeat	164..187	CDD:275380	5/22 (23%)
		leucine-rich repeat	188..214	CDD:275380	8/25 (32%)
		leucine-rich repeat	215..238	CDD:275380	1/22 (5%)
		leucine-rich repeat	239..261	CDD:275380	3/21 (14%)
		LRR_8	260..322	CDD:290566	18/61 (30%)
		leucine-rich repeat	262..286	CDD:275380	6/23 (26%)
		leucine-rich repeat	287..311	CDD:275380	6/23 (26%)
		leucine-rich repeat	346..369	CDD:275380	6/22 (27%)
		leucine-rich repeat	370..388	CDD:275380	6/17 (35%)
lingo4a	NP_001076447.1	LRRNT	41..70	CDD:214470	11/31 (35%)
		leucine-rich repeat	52..72	CDD:275380	8/22 (36%)
		leucine-rich repeat	73..96	CDD:275380	6/28 (21%)
		LRR_RI	88..380	CDD:238064	93/372 (25%)
		LRR_8	95..155	CDD:290566	23/70 (33%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		leucine-rich repeat	121..144	CDD:275380	12/33 (36%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		leucine-rich repeat	169..192	CDD:275380	8/25 (32%)
		LRR_8	191..250	CDD:290566	22/107 (21%)
		leucine-rich repeat	193..216	CDD:275380	11/70 (16%)
		leucine-rich repeat	217..240	CDD:275380	6/23 (26%)
		leucine-rich repeat	241..288	CDD:275380	13/57 (23%)
		LRR_8	264..323	CDD:290566	19/74 (26%)
		leucine-rich repeat	289..310	CDD:275380	8/25 (32%)
		LRR_8	312..371	CDD:290566	15/60 (25%)
		leucine-rich repeat	313..336	CDD:275380	5/24 (21%)
		leucine-rich repeat	337..356	CDD:275380	3/18 (17%)
		I-set	428..512	CDD:254352
		Ig	439..512	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910