DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr19 and PAPLN

DIOPT Version :9

Sequence 1:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001352835.1	Gene:	PAPLN / 89932	HGNCID:	19262	Length:	1278	Species:	Homo sapiens

Alignment Length:	278	Identity:	69/278 - (24%)
Similarity:	100/278 - (35%)	Gaps:	82/278 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIAQKGGLAILPCVVKVNSPATVSWIRRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAV 114
            |.|..|.|..|.|.......:..:|  :||.|.:       |||:.      |.....||.|..:
Human   919 VQAALGQLVRLSCSDDTAPESQAAW--QKDGQPI-------SSDRH------RLQFDGSLIIHPL 968

  Fly   115 REEDRGFYECQLSIYPTQSIVIELKI------VEAVAEISSAPELHIDETSTLRLECKLKRATEN 173
            :.||.|.|.|..:.....|..|:|:|      |.:.||:|..|:                  ..:
Human   969 QAEDAGTYSCGSTRPGRDSQKIQLRIIGGDMAVLSEAELSRFPQ------------------PRD 1015

  Fly   174 PAFVFWYHDSKMINYDSQGGFV--VTSIGQSNPQSGQFYRSSPANKSR--ATMP--MESSNGVLN 232
            ||..|           .|.|..  :.:|..|:||        |||:.|  ...|  :::|.|...
Human  1016 PAQDF-----------GQAGAAGPLGAIPSSHPQ--------PANRLRLDQNQPRVVDASPGQRI 1061

  Fly   233 SLLGSSDAIKAPAA-----NVPSSTPYMTQQHQSAYLLNPSVSVLTVKQVNFRHAGNYTCAPSNA 292
            .:...::....||.     ..|.|:|    :||    |.|..| |.:.:|.....|.|||...|.
Human  1062 RMTCRAEGFPPPAIEWQRDGQPVSSP----RHQ----LQPDGS-LVISRVAVEDGGFYTCVAFNG 1117

  Fly   293 RPAS---ITVHVLRGEKT 307
            :...   :.:.|| ||.|
Human  1118 QDRDQRWVQLRVL-GELT 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	22/76 (29%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	19/69 (28%)
PAPLN	NP_001352835.1	TSP1	29..80	CDD:214559
		ADAM_spacer1	183..298	CDD:310520
		TSP1	308..361	CDD:214559
		TSP1	369..424	CDD:214559
		TSP1	424..481	CDD:214559
		TSP1	488..539	CDD:214559
		Kunitz_BPTI	753..805	CDD:278443
		Papilin_u7	814..905	CDD:318767
		Ig	914..>978	CDD:325142	21/73 (29%)
		I-set	1049..1119	CDD:254352	20/78 (26%)
		IG	1139..1219	CDD:214652
		PLAC	1235..1267	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900