DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr19 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	386	Identity:	78/386 - (20%)
Similarity:	120/386 - (31%)	Gaps:	113/386 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LHLSCFLLLLSSTFSDVGKITSSQNHFGNTLQSQFNTKNNTRVIAQKGGLAILPCVVKVNSPATV 72
            |.|..::|.||.|||.     .:|..|......|       .|:|  |..|:||||: :|....|
Human     2 LSLLVWILTLSDTFSQ-----GTQTRFSQEPADQ-------TVVA--GQRAVLPCVL-LNYSGIV 51

  Fly    73 SWIRRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAVREEDRGFYECQLSIYPTQSIVIE 137
            .|  .||...|.:|... .:..|:.|..:...|.::|.|......|...||||.:....:|...:
Human    52 QW--TKDGLALGMGQGL-KAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAK 113

  Fly   138 LKIV--EAVAEISSAPELHIDETSTLRLECKLKRATENPAFVFWYHDSKMINYDSQGGFVV---- 196
            |.::  .....|...|.:.:...:...|.|:...| :..|.:.|:.|.     ..|.|.|.
Human   114 LTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNA-KPAATIIWFRDG-----TQQEGAVASTEL 172

  Fly   197 -------TSIGQ--SNPQSGQFYRSSPANKSRATMPMESSNGVLNSLLGSSDAIKAPAANVPSST 252
                   |::.|  .||......|..........:|.           |...:|:....:.|:.|
Human   173 LKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPS-----------GKETSIELDVHHPPTVT 226

  Fly   253 ----PYMTQQ-------------------------------HQSAYLLNPSVSVLTVKQVNFRHA 282
                |...|:                               |:|.|..|...|..|
Human   227 LSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFT--------- 282

  Fly   283 GNYTCAPSNARPASITVHVLRGEKTAA----MQHANRSILD-----TETNGNGTFGLITLG 334
                      .|.|..||...|....:    :..|.|.::|     |:...:.|...:.:|
Human   283 ----------EPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	25/76 (33%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	21/69 (30%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	29/106 (27%)
		Ig	25..116	CDD:299845	28/103 (27%)
		Ig2_KIRREL3-like	138..219	CDD:143236	17/97 (18%)
		I-set	223..304	CDD:254352	15/99 (15%)
		Ig_2	227..305	CDD:290606	13/96 (14%)
		Ig_2	311..405	CDD:290606	4/23 (17%)
		IG_like	314..405	CDD:214653	3/20 (15%)
		Ig5_KIRREL3	407..504	CDD:143306
		IG_like	416..504	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810