DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr19 and NTM

DIOPT Version :9

Sequence 1:NP_001260336.1 Gene:dpr19 / 34408 FlyBaseID:FBgn0032233 Length:385 Species:Drosophila melanogaster
Sequence 2:NP_001338930.1 Gene:NTM / 50863 HGNCID:17941 Length:367 Species:Homo sapiens


Alignment Length:330 Identity:83/330 - (25%)
Similarity:131/330 - (39%) Gaps:66/330 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 VIAQKGGLAILPCVVKVNSPATVSWIRRKDFQLLTVGLSTHSSDKR-FLVEHTRHMGHWSLRIKA 113
            |..::|..|.|.|.:. |....|:|:.|.  .:|..|......|.| .|:.:|:  ..:|:.|:.
Human    45 VTVRQGESATLRCTID-NRVTRVAWLNRS--TILYAGNDKWCLDPRVVLLSNTQ--TQYSIEIQN 104

  Fly   114 VREEDRGFYEC--QLSIYP-TQSIVIELKIVEAVAEISSAPELHIDETSTLRLECKLKRATENP- 174
            |...|.|.|.|  |...:| |..:.:.:::...:.||||  ::.|:|.:.:.|.|   .||..| 
Human   105 VDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISS--DISINEGNNISLTC---IATGRPE 164

  Fly   175 AFVFWYHDS-KMINYDSQGGFVVTSIGQSNPQSGQFYRSSPANKSRATM-----------PMESS 227
            ..|.|.|.| |.:.:.|:..::... |.:..|||. |..|.:|...|.:           |..|.
Human   165 PTVTWRHISPKAVGFVSEDEYLEIQ-GITREQSGD-YECSASNDVAAPVVRRVKVTVNYPPYISE 227

  Fly   228 NGVLNSLLGSSDAIKAPAANVPSS-------TPYMTQQHQSAYLLN-PSVSVLTVKQVNFRHAGN 284
            .......:|....::..|:.|||:       ...:.:..:...:.| |.:|.|....|:....||
Human   228 AKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGN 292

  Fly   285 YTCAPSNA--------------RPASITVHVLRGEKTAAMQHANRSILDTETNGNGTFGLITLGG 335
            |||..||.              .|.|.|  :|:..||.|:         |...|.|....::   
Human   293 YTCVASNKLGHTNASIMLFELNEPTSST--LLQEVKTTAL---------TPWKGPGAVSEVS--- 343

  Fly   336 LNGTS 340
             ||||
Human   344 -NGTS 347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr19NP_001260336.1 IG_like 50..127 CDD:214653 23/79 (29%)
IGc2 55..125 CDD:197706 21/72 (29%)
NTMNP_001338930.1 Ig 44..132 CDD:416386 25/91 (27%)
Ig strand A' 44..49 CDD:409353 1/3 (33%)
Ig strand B 51..59 CDD:409353 3/7 (43%)
CDR1 59..63 CDD:409353 1/4 (25%)
FR2 64..70 CDD:409353 2/5 (40%)
Ig strand C 64..70 CDD:409353 2/5 (40%)
CDR2 71..83 CDD:409353 3/13 (23%)
Ig strand C' 72..76 CDD:409353 0/5 (0%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 11/35 (31%)
Ig strand D 87..94 CDD:409353 2/6 (33%)
Ig strand E 97..103 CDD:409353 1/5 (20%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 0/3 (0%)
Ig strand G 123..132 CDD:409353 2/8 (25%)
FR4 125..132 CDD:409353 1/6 (17%)
Ig_3 136..205 CDD:404760 23/75 (31%)
Ig strand A' 142..147 CDD:409353 2/6 (33%)
Ig strand B 153..160 CDD:409353 2/9 (22%)
Ig strand C 166..171 CDD:409353 2/4 (50%)
Ig strand D 177..180 CDD:409353 0/2 (0%)
Ig strand E 184..190 CDD:409353 0/6 (0%)
Ig strand F 197..204 CDD:409353 3/7 (43%)
Ig strand G 211..219 CDD:409353 0/7 (0%)
Ig_3 222..299 CDD:404760 17/76 (22%)
putative Ig strand A 223..229 CDD:409353 2/5 (40%)
Ig strand B 239..243 CDD:409353 0/3 (0%)
Ig strand C 252..256 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 2/3 (67%)
Ig strand F 292..297 CDD:409353 4/4 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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