DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr19 and NCAM1

DIOPT Version :9

Sequence 1:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	411	Identity:	90/411 - (21%)
Similarity:	142/411 - (34%)	Gaps:	96/411 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RWHLHLSCFLLLLSSTFSDVGK-ITSSQNHFGNTLQSQF-------NTKNNTRVIAQKGGLAILP 61
            |.|..:|. |.|.|..::|.|: |.::.|..|...||.:       ..:....|...:|....:.
Human   398 RSHARVSS-LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNIT 461

  Fly    62 CVVKVNSPATVSWIRRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAVREEDRGFYEC-- 124
            |.|.....||:||.|  |.|||.  .|.:|:.|.:......:     |.:....|.|.|.|.|
Human   462 CEVFAYPSATISWFR--DGQLLP--SSNYSNIKIYNTPSASY-----LEVTPDSENDFGNYNCTA 517

  Fly   125 -------QLSIYPTQSIVIELKIVEAVAEISSAPELHIDETST------LRLECKLKRATENPAF 176
                   .|.....|:.......::.|...||..::..||...      |:.:.:.:...|....
Human   518 VNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 582

  Fly   177 VFWYHDSKMINYDSQGGFVVTSIGQSNPQSGQFYRSSPANKSRATMPMESSNGVLNSLLGSSDAI 241
            ..|| |:|..:.:.    :||.:| ..|::....|.:..|          ..| |..:..:|:..
Human   583 SKWY-DAKEASMEG----IVTIVG-LKPETTYAVRLAALN----------GKG-LGEISAASEFK 630

  Fly   242 KAPAANVPSSTPYMTQQHQSAYLLNPSVSVLTVKQVN----FRH-AGNYTCAPSNARP------- 294
            ..|....||:.....|..:.    ..|:.|..:||.:    .|| ...|....|..:|
Human   631 TQPVQGEPSAPKLEGQMGED----GNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSG 691

  Fly   295 ------------ASITVHVL----RGEKTAAMQHANRSILDTETNGNGTFGLITLGGLNGTSGVT 343
                        |...|:|:    :|:..||......|...|....||          :.|||::
Human   692 SDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANG----------SPTSGLS 746

  Fly   344 LAG--GILYFSGLFLLMGAVV 362
            ...  |||..  :|:|:..||
Human   747 TGAIVGILIV--IFVLLLVVV 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	22/85 (26%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	21/78 (27%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652
		Ig	211..307	CDD:325142
		Ig	306..438	CDD:325142	13/40 (33%)
		Ig_3	447..519	CDD:316449	22/80 (28%)
		FN3	534..631	CDD:238020	20/113 (18%)
		fn3	639..720	CDD:306538	15/84 (18%)
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810