DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr19 and itgb4

DIOPT Version :9

Sequence 1:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	290	Identity:	66/290 - (22%)
Similarity:	106/290 - (36%)	Gaps:	79/290 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TFSDVGKITSSQNHFGNTLQSQFNTKNNTRVIAQKGGL-AILPCVVKVNSPATVSWIRRKDFQLL 83
            :|.:|.|:||:...|...||.:..:.|   :.|.:||. |||...|..:.   :.|  |||
Zfish   200 SFRNVIKLTSNITSFRQKLQKERISGN---LDAPEGGFDAILQTAVCQDQ---IGW--RKD---- 252

  Fly    84 TVGLSTHSSDKRFLVEHTRHMGHWSLRIKAVREE--DRGFYECQLSI-----------YPTQSIV 135
                |||     .||..|....|:......|...  ||...:|.|::           ||:...:
Zfish   253 ----STH-----LLVFSTESAFHYEADGANVLAGILDRNDEQCHLNVDGNYTHDVRQDYPSIPTL 308

  Fly   136 IELKI------VEAVAE--------------ISSAPELHIDETSTLRLECKLKRATENPAFVFWY 180
            :.|.:      :.||..              |:...:|..|.::.|.:   |::|.||..
Zfish   309 VRLLVKHNIIPIFAVTNHSYSYYEKLHEYFPIAELGQLQEDSSNILSI---LEKAFENIR----- 365

  Fly   181 HDSKM-INYDSQGGFVVTSIGQSNPQSGQF-----YRSSPANKSRATMPMESSNGVLNSLLGSSD 239
              ||: |..:.:...|.|.|..   |||.|     ::.:|....:..:.|::.|.|     |...
Zfish   366 --SKISIRAEDRPKAVETKIFS---QSGTFSEYGNFKITPGQTGKFKVRMKALNQV-----GEEP 420

  Fly   240 AIKAPAANVPSSTPYMTQQHQSAYLLNPSV 269
            ..|...|:...:.........||:.:|..|
Zfish   421 VCKVNQADRAGTLRVKPTTFSSAFKINAEV 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	22/79 (28%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	20/72 (28%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776	66/290 (23%)
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020
		FN3	1331..1420	CDD:238020
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900