DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr19 and Igsf9

DIOPT Version :9

Sequence 1:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	76/343 - (22%)
Similarity:	117/343 - (34%)	Gaps:	125/343 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIAQKGGLAILPCVVKVNSPA------TVSWIRRKDFQL---LTVGLSTHSSDKRFLVEHTRHMG 105
            |:.:.|..|:|.|  .:..||      .:.|: |..|.|   :..||.:...|..: |...|...
  Rat    29 VVGRAGESAVLGC--DLLPPAGRPPLHVIEWL-RFGFLLPIFIQFGLYSPRIDPDY-VGRVRLQT 89

  Fly   106 HWSLRIKAVREEDRGFYECQL--------------------------SIYPTQSIVIELKIVEAV 144
            ..||:|:.:|.||:|:|||::                          ....|..:|:|:|.:|||
  Rat    90 GASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQFQETPPLVLEVKELEAV 154

  Fly   145 AEISSAPELHIDETSTLRLECKLKRATENP-AFVFWYHDSKMINYDSQGGFVVTSIGQSNPQSGQ 208
                           |||  |.   |..:| .:|.|    |....|...|     .||...::|.
  Rat   155 ---------------TLR--CV---ALGSPQPYVTW----KFRGQDLGKG-----QGQVQVRNGT 190

  Fly   209 FY-----RSSPANKSRATMPMESS--------------------NGVLNSLLGSSDAIKAPAANV 248
            .:     |.|..:.:......|.|                    |..:|:....|.|.:|.|  .
  Rat   191 LWIRRVERGSAGDYTCQASSTEGSVTHTTQLLVLGPPVIVVPPNNNTVNASQDVSLACRAEA--Y 253

  Fly   249 PSSTPYMTQQHQSAYLLNPSVSVLTVKQVNFR-----------------HAGNYTCAPSNARP-- 294
            |::..|...|.:        ::|..:.::..|                 .||:|||.|||..|
  Rat   254 PANLTYSWFQDR--------INVFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSNGFPHP 310

  Fly   295 --ASITVHVLRGEKTAAM 310
              ||..:.||...:...|
  Rat   311 PSASAYLTVLYPAQVTVM 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	26/111 (23%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	24/78 (31%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	26/84 (31%)
		Ig strand A	136..139	CDD:409353	0/2 (0%)
		IG_like	143..223	CDD:214653	24/108 (22%)
		Ig strand A'	145..148	CDD:409353	1/2 (50%)
		Ig strand B	154..161	CDD:409353	5/26 (19%)
		Ig strand C	167..172	CDD:409353	2/8 (25%)
		Ig strand C'	175..177	CDD:409353	0/1 (0%)
		Ig strand D	183..187	CDD:409353	1/3 (33%)
		Ig strand E	189..193	CDD:409353	1/3 (33%)
		Ig strand F	202..210	CDD:409353	0/7 (0%)
		Ig strand G	213..223	CDD:409353	1/9 (11%)
		Ig_3	226..305	CDD:404760	17/88 (19%)
		putative Ig strand A	226..230	CDD:409353	0/3 (0%)
		putative Ig strand A'	235..239	CDD:409353	1/3 (33%)
		putative Ig strand B	241..251	CDD:409353	2/9 (22%)
		putative Ig strand C'	267..270	CDD:409353	1/2 (50%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	0/5 (0%)
		putative Ig strand F	297..305	CDD:409353	5/7 (71%)
		putative Ig strand G	310..319	CDD:409353	2/8 (25%)
		Ig	322..407	CDD:416386	1/7 (14%)
		Ig strand A'	324..328	CDD:409353	0/3 (0%)
		Ig strand B	333..347	CDD:409353
		Ig strand C	353..359	CDD:409353
		Ig strand C'	362..364	CDD:409353
		Ig strand D	371..374	CDD:409353
		Ig strand E	378..382	CDD:409353
		Ig strand F	391..399	CDD:409353
		Ig	418..503	CDD:416386
		Ig strand A	418..421	CDD:409353
		Ig strand A'	427..430	CDD:409353
		Ig strand B	436..443	CDD:409353
		Ig strand C	449..454	CDD:409353
		Ig strand C'	457..459	CDD:409353
		Ig strand D	462..466	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	482..490	CDD:409353
		Ig strand G	493..503	CDD:409353
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900