DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr19 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	83/404 - (20%)
Similarity:	142/404 - (35%)	Gaps:	91/404 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLSSTFSDVGKITSSQNHFGNTLQSQFNTKNNTRVIAQKGGLAILPCVVKVNSPATVSWIRRKD 79
            ||||  |..:|.:.||    |..|...  |.:.::|....|......|.. :..|.::.|...:.
  Rat     3 LLLS--FYLLGLLVSS----GQALLQV--TISLSKVELSVGESKFFTCTA-IGEPESIDWYNPQG 58

  Fly    80 FQLLTVGLSTHSSDKRFLV--EHTRHMGHWSLRIKAVREEDRGFYECQLSIY--PTQSIVIELKI 140
            .:::        |.:|.::  |..|.    .|.|.....||.|.|.||.:..  .||...:.|:|
  Rat    59 EKII--------STQRVMLQKEGVRS----RLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEI 111

  Fly   141 VEAVA--EISSAPELHIDETSTLRLECKLKRATENPAFVFWYHDSKMINYDSQGGFVVTS----I 199
            .:.:.  |:.|..|....|.:  .:.|::. ::..||..:.||:.::.........|:.:    |
  Rat   112 YQKLTFREVLSPQEFKQGEDA--EVVCRVS-SSPAPAVSWLYHNEEVTTIPDNRFAVLANNNLQI 173

  Fly   200 GQSNPQSGQFYRSSPANKSRA-----------------TMPMESSNGVLNSLLGSSDAIKAPAAN 247
            ...|......||.....::|.                 .||.:|.|.....  |....:...|:.
  Rat   174 LNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAIVMPQKSFNATAER--GEEMTLTCKASG 236

  Fly   248 VPSSTPYMTQ-------QHQSAYLLNPSVSVLTVKQVNFRHAGNYTCAPSN-----ARPASITVH 300
            .|.  |.::.       :....|:|..|.:.|||:.:..:..|:|.|..:|     .:.|.:.|.
  Rat   237 SPD--PAISWFRNGKLIEENEKYILKGSNTELTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVF 299

  Fly   301 V------LRGEKTAAMQHAN---------------RSILDTETNGNG---TFGLITLGGLNGTSG 341
            |      |:.|.|:...|..               :..:|..|...|   ..|.|.:.|.:|.|.
  Rat   300 VQPHILQLKNETTSENGHVTLICEAEGEPVPEITWKRAIDGVTFSEGDKSPDGRIEVKGQHGRSS 364

  Fly   342 VTLAGGILYFSGLF 355
            :.:....|..||.:
  Rat   365 LHIRDVKLSDSGRY 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	17/78 (22%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	14/71 (20%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452	22/106 (21%)
		Ig strand B	38..42	CDD:409452	0/3 (0%)
		Ig strand C	50..54	CDD:409452	0/3 (0%)
		Ig strand E	76..80	CDD:409452	1/7 (14%)
		Ig strand F	90..95	CDD:409452	2/4 (50%)
		Ig strand G	104..107	CDD:409452	0/2 (0%)
		IGc2	128..189	CDD:197706	11/63 (17%)
		Ig strand B	130..139	CDD:409353	2/10 (20%)
		Ig strand C	145..153	CDD:409353	3/7 (43%)
		Ig strand C'	156..159	CDD:409353	0/2 (0%)
		Ig strand D	162..167	CDD:409353	1/4 (25%)
		Ig strand E	168..175	CDD:409353	1/6 (17%)
		IgI_1_MuSK	209..298	CDD:409562	19/92 (21%)
		Ig strand B	228..232	CDD:409562	0/3 (0%)
		Ig strand C	241..245	CDD:409562	0/3 (0%)
		Ig strand E	264..268	CDD:409562	1/3 (33%)
		Ig strand F	278..283	CDD:409562	2/4 (50%)
		Ig strand G	291..294	CDD:409562	0/2 (0%)
		Ig	300..397	CDD:416386	16/79 (20%)
		Ig strand A	300..305	CDD:409353	1/4 (25%)
		Ig strand A'	309..313	CDD:409353	1/3 (33%)
		Ig strand B	317..325	CDD:409353	1/7 (14%)
		Ig strand C	331..337	CDD:409353	0/5 (0%)
		Ig strand C'	340..343	CDD:409353	0/2 (0%)
		Ig strand D	353..359	CDD:409353	1/5 (20%)
		Ig strand E	362..368	CDD:409353	1/5 (20%)
		Ig strand F	376..384	CDD:409353	1/3 (33%)
		Ig strand G	387..397	CDD:409353
		Ig_3	401..479	CDD:404760
		Ig strand B	418..422	CDD:409353
		Ig strand C	431..435	CDD:409353
		Ig strand E	458..462	CDD:409353
		Ig strand F	472..477	CDD:409353
		Ig strand G	486..489	CDD:409353
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900