DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr19 and IGSF9B

DIOPT Version :9

Sequence 1:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	407	Identity:	81/407 - (19%)
Similarity:	144/407 - (35%)	Gaps:	88/407 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EPKRWHLHLSCFLLLLSSTFSDVGKITSSQNHFGNTLQSQFN-----TKNNTRVI-AQKGGLAIL 60
            |.:.|:   .|.:|:|...:...        |.|:.:....|     |:...:.| |::||...:
Human   106 EDQGWY---ECKVLMLDQQYDTF--------HNGSWVHLTINAPPTFTETPPQYIEAKEGGSITM 159

  Fly    61 PCVVKVNSPATVSWIRRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAVREEDRGFYECQ 125
            .|....|....|:|:  |:..||........||             .||.:.:|..||||.|.|:
Human   160 TCTAFGNPKPIVTWL--KEGTLLGASGKYQVSD-------------GSLTVTSVSREDRGAYTCR 209

  Fly   126 LSIYPTQSIVIELKIVEAVAEISSAPE-LHIDETSTLRLECKLKRATENPAFVFWYHDSKMINYD 189
            ......:::.....:|:....|.|.|| :.::.:....|.|:.:....|..:. ||...:.:.:.
Human   210 AYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYT-WYWQDENVYFQ 273

  Fly   190 S----------QGGFVVTSIGQSNPQSGQFYRSSPAN------KSRATMPMESSNGVLNS----- 233
            :          .|..::..:   .|:....|...|:|      .:.|.:.::....|||.
Human   274 NDLKLRVRILIDGTLIIFRV---KPEDSGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIY 335

  Fly   234 -LLGSSDAIKAPAANVPSST---------PYMTQQHQSAYLLNPSVSVLTVKQVNFRHAGNYTCA 288
             .:|....|:.|....|.:|         |...:::....|:..  ..:.:::......|.|||.
Human   336 VPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMED--GSIRIEEATEEALGTYTCV 398

  Fly   289 PSN-------ARPASITVH------VLRGEKTAAMQHANRSILDTETNGNGTFGLIT---LGGLN 337
            |.|       :.||.:.:.      ||.|.:  ..|.|.|.:|.........|.:||   :|..:
Human   399 PYNTLGTMGQSAPARLVLKDPPYFTVLPGWE--YRQEAGRELLIPCAAAGDPFPVITWRKVGKPS 461

  Fly   338 GTSGVTLAGGILYFSGL 354
            .:....|..|.|.|..|
Human   462 RSKHSALPSGSLQFRAL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	22/77 (29%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	19/69 (28%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	3/11 (27%)
		Ig	41..115	CDD:143165	3/11 (27%)
		I-set	139..225	CDD:254352	23/100 (23%)
		IGc2	153..210	CDD:197706	20/71 (28%)
		I-set	229..321	CDD:254352	15/95 (16%)
		Ig	235..321	CDD:299845	13/89 (15%)
		IG_like	331..414	CDD:214653	15/84 (18%)
		Ig	<353..414	CDD:299845	11/62 (18%)
		IG_like	426..505	CDD:214653	14/55 (25%)
		Ig	442..505	CDD:299845	9/37 (24%)
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810