DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr19 and DSCAM

DIOPT Version :9

Sequence 1:NP_001260336.1 Gene:dpr19 / 34408 FlyBaseID:FBgn0032233 Length:385 Species:Drosophila melanogaster
Sequence 2:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens


Alignment Length:575 Identity:106/575 - (18%)
Similarity:174/575 - (30%) Gaps:226/575 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 HLHLSCFLLLL---SSTFSDV--------------GKITSSQNHFGNTLQSQFNTKNNTRVIAQK 54
            |:|.:..|.:.   .|:||.:              |||.|...|....|:..:    ..||..||
Human    74 HVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPY----TVRVEDQK 134

  Fly    55 ---GGLAILPCVVKVNSPA---TVSWIRRKDFQLLTVGLSTHSSDKRFLVEH------------- 100
               |.:|:..|::..:..|   .|||  .||    ||.|   .|..|||:..             
Human   135 TMRGNVAVFKCIIPSSVEAYITVVSW--EKD----TVSL---VSGSRFLITSTGALYIKDVQNED 190

  Fly   101 --------TRH-----------------------------------------------MGH---- 106
                    |||                                               :||    
Human   191 GLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPD 255

  Fly   107 --W------------------SLRIKAVREEDRGFYECQLS-IYPTQSIVIELKIVEAVAEISSA 150
              |                  .|.|:.:|..|.|.|.|::| .|.|..::..|.:.:.:....|.
Human   256 YRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP 320

  Fly   151 PELHIDETSTLRLECKLKRATENPAFVFWYHDSKMINYDSQGGFV-VTSIGQSN-------PQSG 207
            .::.....|.:.|.|.: ..||:.. :.||.:.:::|   .|..| :|.|...|       ...|
Human   321 RKVKSSVGSQVSLSCSV-TGTEDQE-LSWYRNGEILN---PGKNVRITGINHENLIMDHMVKSDG 380

  Fly   208 QFYRSSPANKSRAT----MPMESSNGVLNSLLGSSDAIKAPAANVP-----SSTPYMT------- 256
            ..|:.. ..|.:.:    :.:...:|....:...|:.:.:||..|.     ..||..|       
Human   381 GAYQCF-VRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDD 444

  Fly   257 ------QQHQSAYLLNPS---VSVLTVKQVNFRHAGNYTCAPSNAR-------------PASI-- 297
                  ..|:.:.::...   ||.|.:.....|..|.|.|..:|:.             ||||  
Human   445 DPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRP 509

  Fly   298 --TVHVLRGEKT------------AAMQHANRSIL-----DTETNGNGTFGL------------- 330
              .:..:.|..|            :...:.|.::|     ......|||..|             
Human   510 MKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYT 574

  Fly   331 ---ITLGGLNGTSGVTLAGGILYFSGLFLLMGAVVFDRFSLAATHKVFVAFIIVT 382
               :....|:.:..|.:...:..|...|      .|.|||:.  .:||:..::|:
Human   575 CNVLVQPQLSTSQSVHVTVKVPPFIQPF------EFPRFSIG--QRVFIPCVVVS 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr19NP_001260336.1 IG_like 50..127 CDD:214653 32/174 (18%)
IGc2 55..125 CDD:197706 28/164 (17%)
DSCAMNP_001380.2 Ig 45..113 CDD:319273 9/38 (24%)
I-set 235..310 CDD:254352 14/74 (19%)
I-set 315..385 CDD:333254 16/74 (22%)
Ig_3 407..488 CDD:316449 15/80 (19%)
IGc2 518..575 CDD:197706 8/56 (14%)
I-set 596..686 CDD:333254 9/34 (26%)
Ig_DSCAM 707..784 CDD:143211
Ig 802..889 CDD:325142
FN3 885..978 CDD:238020
FN3 986..1083 CDD:238020
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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