DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr19 and Dscam

DIOPT Version :9

Sequence 1:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus

Alignment Length:	350	Identity:	78/350 - (22%)
Similarity:	129/350 - (36%)	Gaps:	94/350 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLLLSSTFSDVGK-ITSSQNHFGN--------TLQSQFNTKNNTRVIAQKGGLAILPCVVKVNSP 69
            ||:.:|..||.|. :....|.:|.        ..|....|.:..:|.:..|....|.|.|..|..
Mouse   278 LLIENSRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGNED 342

  Fly    70 ATVSWIRRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAVREEDRGFYEC-----QLSIY 129
            ..:||.|  :.::|..|.:...:.          :.|.:|.:..:.:.|.|.|:|     :||..
Mouse   343 QELSWYR--NGEILNPGKNVRITG----------LNHANLIMDHMVKSDGGAYQCFVRKDKLSAQ 395

  Fly   130 PTQSIVIE---LKIVEAVAEISSAPELHIDETSTLRLECKLKRATENPAFVFWYHD--------- 182
            ....:|:|   .||:.|.:|...:|      ...:.|.|.:| .|..|. |.|..|
Mouse   396 DYVQVVLEDGTPKIISAFSEKVVSP------AEPVSLVCNVK-GTPLPT-VTWTLDDDPILKGSG 452

  Fly   183 ---SKMINYDSQGGFV-VTSIGQSNPQSGQFYRSSPANKSRATM--------------PMESSNG 229
               |:||.  |:|..| ..:|..|..:.|..||.:..|.:...:              ||::
Mouse   453 HRISQMIT--SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKN--- 512

  Fly   230 VLNSLLGSSDAIKAPAANVPSSTPYMTQQHQSAYLL-----------NPSVSVLTV-KQVNFRHA 282
             :.::.|....|.......|.   |..:.:::|.||           |.::.:..| |:|:   .
Mouse   513 -ITAIAGRDTYIHCRVIGYPY---YSIKWYKNANLLPFNHRQVAFENNGTLKLSDVQKEVD---E 570

  Fly   283 GNYTC----AP--SNARPASITVHV 301
            |.|||    .|  |.::...:||.|
Mouse   571 GEYTCNVLVQPQLSTSQSVHVTVKV 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	17/81 (21%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	16/74 (22%)
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706	7/21 (33%)
		IG	320..400	CDD:214652	19/91 (21%)
		Ig_3	410..488	CDD:372822	22/87 (25%)
		IGc2	518..575	CDD:197706	13/62 (21%)
		Ig	596..686	CDD:386229	77/349 (22%)
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:386229
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900