DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cand1 and CAND1

DIOPT Version :10

Sequence 1:NP_609389.1 Gene:Cand1 / 34403 FlyBaseID:FBgn0027568 Length:1248 Species:Drosophila melanogaster
Sequence 2:NP_178360.2 Gene:CAND1 / 814786 AraportID:AT2G02560 Length:1219 Species:Arabidopsis thaliana


Alignment Length:1249 Identity:498/1249 - (39%)
Similarity:759/1249 - (60%) Gaps:56/1249 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 QIANLLEK--MTSTDKDFRFMATNDLMTELQKDSIILDDESEKKVVRMVLKLLEDKNGEVQNLAV 70
            |::.:|||  ||..|||:|:|||:||:.||.|||..:|.:.|.::..::|:.|:|..|:|..|||
plant     5 QVSGILEKFQMTGKDKDYRYMATSDLLNELNKDSFKIDLDLEVRLSSIILQQLDDVAGDVSGLAV 69

  Fly    71 KCLGPLVNKVKEIQVETIVDSLCANMMSNTEQLRDISSIGLKTVIAELPQSSNSLAPNVCQRITG 135
            |||.|||.||.|.::..:.:.||..::...:|.||.:||.|:||:|::   :.:|||::...:|.
plant    70 KCLAPLVKKVGEERIVEMTNKLCDKLLHGKDQHRDTASIALRTVVAQI---APTLAPSILVTLTP 131

  Fly   136 KLSTAIEKEDVS--VKLESLDILADLLSRFGEFLVPFHSTILKALMPQLASSRQAVRKRTIVALS 198
            ::...|..:.:|  :|.|.|:|:.|::.::|..:...|..:|..|:.||..::..|||:|:..::
plant   132 QMIGGISGQGMSSGIKCECLEIMCDVVQKYGSLMTDDHEKLLNTLLLQLGCNQATVRKKTVTCIA 196

  Fly   199 FLLIQANSNAYNGVIDHLLDGLENPPNPAAI-RTYIQCLASICRQAGHRLCNHIDRSMLLLSQY- 261
            .|....:.:........::..|.|....:.| ||.||.:.::||..|:|...|:..::.:|..| 
plant   197 SLASSLSDDLLAKATVEVVKNLSNRNAKSEITRTNIQMIGALCRAVGYRFGTHLGNTVPVLINYC 261

  Fly   262 --SQRDDDELREFCLQACEAFVMRCPDAINPHIPMILELCLNYITYDPNY--NYETDDGDTGNAM 322
              :..:|:||||:.|||.|:|::|||..|:|:...||.|.|.||:||||:  |.| :|.|.....
plant   262 TSASENDEELREYSLQALESFLLRCPRDISPYCDEILNLTLEYISYDPNFTDNME-EDTDNETLE 325

  Fly   323 DTEDDEYVDSEEYSDDDDMSWKVRRAAAKCLEVLISTRQELVEDFYRSLSPALIARFKEREENVK 387
            |.||||  .:.||:||:|.||||||||||||..||.:|.|::...|:...|.||.||||||||||
plant   326 DEEDDE--SANEYTDDEDASWKVRRAAAKCLAGLIVSRSEMLTKVYQEACPKLIDRFKEREENVK 388

  Fly   388 SDIFHAYVALLKNTRLTDDVANDHDSMDQVSGPTSLLIEQLPLIVKAIQPLMREKSMKTRQDCFL 452
            .|:|:.::.||   |.|.:|.......|: |.|..||.:::..|||:|...:||||:||:...|.
plant   389 MDVFNTFIDLL---RQTGNVTKGQTDTDE-SSPKWLLKQEVSKIVKSINRQLREKSVKTKVGAFS 449

  Fly   453 LLRELLNSLPGALGPYLDSIVPGISYSLNDKSSTSNMKIESLGFLYSLLQGHPPHVFHPHIPLLV 517
            :||||:..||..|..::.|:||||..:|||||||||:|||:|.|...:|..|.|.||||:|..|.
plant   450 VLRELVVVLPDCLADHIGSLVPGIERALNDKSSTSNLKIEALVFTKLVLASHAPPVFHPYIKALS 514

  Fly   518 PLVVTSVFDPFYKIATEALLVLQQLVKVIRPLEPNAAKSDFDAPSFVGQVYSCTLQKLKVTDVDQ 582
            ..|:.:|.:.:||:..|||.|..:||:|:|   |:.|...||...||..:|:..:.:|...|.||
plant   515 SPVLAAVGERYYKVTAEALRVCGELVRVVR---PSTAGMGFDFKPFVHPIYNAIMSRLTNQDQDQ 576

  Fly   583 EVKERAIACMGQIIANMGDMLQNELAVCLPIFMERLKNEVTRLSSVKALTLIAASSLRIDLTPIL 647
            ||||.||.|||.:|:..||.|:.||..|||:.::|:.||:|||::|||.::||.|.|.|:|:.:|
plant   577 EVKECAITCMGLVISTFGDQLRAELPSCLPVLVDRMGNEITRLTAVKAFSVIATSPLHINLSCVL 641

  Fly   648 HDVLPALGTFLRKNHRALKLHSLDLINKIVINYSSNFEANLLQTAIVEIPPLISDSDLHVAQYSL 712
            ..::..|..||||.:|.|:..:|..:|.:|..|.....:...:..:||:..|||.||||:...:|
plant   642 DHLIAELTGFLRKANRVLRQATLITMNTLVTAYGDKIGSEAYEVILVELSSLISVSDLHMTALAL 706

  Fly   713 TLLSTVARRQ---PQALVGIHEQFLRSVLILVRSPLLQGSALNCTLELFQALVQTQLSGLDYHSL 774
            .|..|:...:   ....:.:..:.|...|.||:||||||.||....:.|:|||..  :...:::|
plant   707 ELCCTLMTGKSCSENISLAVRNKVLPQALTLVKSPLLQGQALLDLQKFFEALVYH--ANTSFYTL 769

  Fly   775 VSKLMA---PVLGGNGDVKSRATAGAPSEVVQLHKQAYHSSAKCIAAL-----TQQCPQVATPLA 831
            :..|::   |         |..:.|.|       |||.:|.|:|:|.|     .:.|......| 
plant   770 LESLLSCAKP---------SPQSGGVP-------KQALYSIAQCVAVLCLAAGDKNCSSTVKML- 817

  Fly   832 TKLITDLQKRNDTEIIFCLLTIGEIGRHFDLSSIQVLPQTIIECFGATSEDVKAAASHALGAVSV 896
            .:::.|....|..:....||::|||||..|||:...:...:||.|.:..|::|:|||:|||.::|
plant   818 MEILKDDSGTNSAKQHLALLSLGEIGRRKDLSAHAGIETIVIESFQSPFEEIKSAASYALGNIAV 882

  Fly   897 GSLQTYLPLILHEIEVQPKRQYLLLHSLKEVISSLSVSPSGLAQLLPSVPSIWDQLFKHCECSEE 961
            |:|..|||.||.:|:.|.|:||:|||||||||...||..:....  .||..|...||.|||..||
plant   883 GNLSNYLPFILDQIDNQQKKQYILLHSLKEVIVRQSVDKADFQN--SSVEKILALLFNHCESEEE 945

  Fly   962 GSRNVVAECLGKLVLVNPDELLPQLQQALRSESATMRTVVVSSVKFTISDQPQPIDVLLKQNIGE 1026
            |.||||||||||:.|:.|::|:|.||....|.:|..|..||::||:::.::|:.:|.::...|..
plant   946 GVRNVVAECLGKMALIEPEKLVPALQVRTTSPAAFTRATVVTAVKYSVVERPEKLDEIIFPQISS 1010

  Fly  1027 FLFALRDPEPQVRRVALVAFNSAVHNKPSLVRDLLPTLLPWLYSETKVKSELIREVEMGPFKHTV 1091
            ||..::|.:..|||.|:.|.::..|.||:|::.|||.|||.||.:|.:|.||||.|::|||||.|
plant  1011 FLMLIKDGDRHVRRAAVSALSTFAHYKPNLIKGLLPELLPLLYDQTVIKKELIRTVDLGPFKHVV 1075

  Fly  1092 DDGLDIRKAAFECMYTLLEQGLDRVDVMQFL-DHVQAGLCDHYDIKMLTYLMTARLAILCPDKVL 1155
            ||||::|||||||::||::..||:|:...|: ..:::||.||||:|||.:|:.:.||..||..||
plant  1076 DDGLELRKAAFECVFTLVDSCLDQVNPSSFIVPFLKSGLEDHYDLKMLCHLILSLLADKCPSAVL 1140

  Fly  1156 LRLDQFIQQLRDTCTHKVKANSVKQEYEKQDELKRSALRAVSALSQIPKANKNQQLVDFLKSIKE 1220
            ..||..::.|..|.:.|.|.::||||:::.:::.||||||:|:|.:|...:.:.:....:..:|.
plant  1141 AVLDSLVEPLHKTISFKPKQDAVKQEHDRNEDMIRSALRAISSLDRINGVDYSHKFKGLMGDMKR 1205

  Fly  1221 TPELNKIFEYIQKD 1234
            :..|.:.|:.|:.:
plant  1206 SVPLWEKFQTIRNE 1219

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cand1NP_609389.1 HEAT repeat 9..33 CDD:293787 14/25 (56%)
HEAT repeat 50..78 CDD:293787 13/27 (48%)
HEAT repeat 87..118 CDD:293787 11/30 (37%)
HEAT repeat 132..158 CDD:293787 7/27 (26%)
HEAT_EZ 147..200 CDD:463906 16/54 (30%)
HEAT repeat 171..200 CDD:293787 9/28 (32%)
HEAT repeat 212..242 CDD:293787 8/30 (27%)
HEAT repeat 253..277 CDD:293787 9/26 (35%)
HEAT repeat 513..538 CDD:293787 9/24 (38%)
HEAT repeat 545..569 CDD:293787 8/23 (35%)
HEAT repeat 609..636 CDD:293787 13/26 (50%)
HEAT repeat 647..676 CDD:293787 10/28 (36%)
HEAT repeat 982..1011 CDD:293787 11/28 (39%)
HEAT repeat 1022..1050 CDD:293787 9/27 (33%)
TIP120 1056..1210 CDD:430111 74/154 (48%)
CAND1NP_178360.2 HEAT repeat 854..879 CDD:293787 10/24 (42%)
HEAT repeat 889..912 CDD:293787 14/22 (64%)
HEAT <930..1030 CDD:441023 42/99 (42%)
HEAT repeat 932..959 CDD:293787 19/26 (73%)
HEAT repeat 965..994 CDD:293787 11/28 (39%)
HEAT repeat 1003..1032 CDD:293787 9/28 (32%)
TIP120 1053..1194 CDD:430111 66/140 (47%)

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