DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cand1 and CAND1

DIOPT Version :9

Sequence 1:NP_001260333.1 Gene:Cand1 / 34403 FlyBaseID:FBgn0027568 Length:1248 Species:Drosophila melanogaster
Sequence 2:NP_060918.2 Gene:CAND1 / 55832 HGNCID:30688 Length:1230 Species:Homo sapiens


Alignment Length:1256 Identity:737/1256 - (58%)
Similarity:941/1256 - (74%) Gaps:34/1256 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASHQYHQIANLLEKMTSTDKDFRFMATNDLMTELQKDSIILDDESEKKVVRMVLKLLEDKNGEV 65
            |||..|| |:||||||||:|||||||||||||||||||||.|||:||:|||:|:|||||||||||
Human     1 MASASYH-ISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEV 64

  Fly    66 QNLAVKCLGPLVNKVKEIQVETIVDSLCANMMSNTEQLRDISSIGLKTVIAELP--QSSNSLAPN 128
            ||||||||||||:||||.|||||||:||.||:|:.|||||||||||||||.|||  .|.::||.|
Human    65 QNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAAN 129

  Fly   129 VCQRITGKLSTAIEK-EDVSVKLESLDILADLLSRFGEFLVPFHSTILKALMPQLASSRQAVRKR 192
            ||::|||:|::||.| |||||:||:|||:||:|||.|..||.||.:||..|:|||.|.|.|||||
Human   130 VCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKR 194

  Fly   193 TIVALSFLLIQANSNAYNGVIDHLLDGLENPPNPAAIRTYIQCLASICRQAGHRLCNHIDRSMLL 257
            ||:||..|::...:..:..:|:|||..|....:.:..||||||:|:|.||||||:..::::.:.|
Human   195 TIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPL 259

  Fly   258 LSQYSQRDDDELREFCLQACEAFVMRCPDAINPHIPMILELCLNYITYDPNYNYETDDGDTGNAM 322
            :.::...|||||||:|:||.|:||.|||..:.||:..|:.:||.|:||||||||:.:|.|. |||
Human   260 VVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDE-NAM 323

  Fly   323 DT---EDDEYVDSEEYSDDDDMSWKVRRAAAKCLEVLISTRQELVEDFYRSLSPALIARFKEREE 384
            |.   :||:....:||||||||||||||||||||:.::|||.|::.:||:::|||||:|||||||
Human   324 DADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREE 388

  Fly   385 NVKSDIFHAYVALLKNTRLTDDVANDHDSMDQVSGPTSLLIEQLPLIVKAIQPLMREKSMKTRQD 449
            |||:|:||||::|||.||.......|.|:|:|...|.::|..|:|.||||:...|:|||:||||.
Human   389 NVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQC 453

  Fly   450 CFLLLRELLNSLPGALGPYLDSIVPGISYSLNDKSSTSNMKIESLGFLYSLLQGHPPHVFHPHIP 514
            ||.:|.||:|.|||||..::..:||||.:|||||||:||:||::|..||.:|..|.|.|||||:.
Human   454 CFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQ 518

  Fly   515 LLVPLVVTSVFDPFYKIATEALLVLQQLVKVIRPLEPNAAKSDFDAPSFVGQVYSCTLQKLKVTD 579
            .|||.||..|.||||||.:|||||.||||||||||:   ..|.|||..::..:::||:::||..|
Human   519 ALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLD---QPSSFDATPYIKDLFTCTIKRLKAAD 580

  Fly   580 VDQEVKERAIACMGQIIANMGDMLQNELAVCLPIFMERLKNEVTRLSSVKALTLIAASSLRIDLT 644
            :|||||||||:||||||.|:||.|.::|...|.||:||||||:|||::||||||||.|.|:|||.
Human   581 IDQEVKERAISCMGQIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLR 645

  Fly   645 PILHDVLPALGTFLRKNHRALKLHSLDLINKIVINYSSNFEANLLQTAIVEIPPLISDSDLHVAQ 709
            |:|.:.:|.|.:|||||.|||||.:|..::.::.|||.:..|.::...:.|:|||||:||:||:|
Human   646 PVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQ 710

  Fly   710 YSLTLLSTVARRQPQALVGIHEQFLRSVLILVRSPLLQGSALNCTLELFQALVQTQLSGLDYHSL 774
            .:::.|:|:|:..|.:|..|....|..::.|||||||||.||:..|:.|||||.|..:.|.|..|
Human   711 MAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDL 775

  Fly   775 VSKLMAPVLGGNGDVKSRATAGAPSEVVQLHKQAYHSSAKCIAALTQQCPQVATPLATKLITDLQ 839
            :..|..||.       |::||       ..|||:|:|.|||:||||:.||:....:..:.|.|::
Human   776 LRMLTGPVY-------SQSTA-------LTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVK 826

  Fly   840 KRNDTEII--FCLLTIGEIGRHFDLSSIQVLPQTIIECFGATSEDVKAAASHALGAVSVGSLQTY 902
            ....|:.|  ..||::||:|.|.|||....|...|:|.|.:.||:||:|||:|||::|||:|..|
Human   827 NSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEY 891

  Fly   903 LPLILHEIEVQPKRQYLLLHSLKEVISSLSVSPSGLAQLLPSVPSIWDQLFKHCECSEEGSRNVV 967
            ||.:|.||..||||||||||||||:|||.||     ..|.|.|.:||..|.|||||:|||:||||
Human   892 LPFVLQEITSQPKRQYLLLHSLKEIISSASV-----VGLKPYVENIWALLLKHCECAEEGTRNVV 951

  Fly   968 AECLGKLVLVNPDELLPQLQQALRSESATMRTVVVSSVKFTISDQPQPIDVLLKQNIGEFLFALR 1032
            |||||||.|::|:.|||:|:..|.|.|:..|:.||::|||||||.|||||.|||..||:||..|.
Human   952 AECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLE 1016

  Fly  1033 DPEPQVRRVALVAFNSAVHNKPSLVRDLLPTLLPWLYSETKVKSELIREVEMGPFKHTVDDGLDI 1097
            ||:..|||||||.||||.||||||:||||.|:||.||:||||:.|||||||||||||||||||||
Human  1017 DPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDI 1081

  Fly  1098 RKAAFECMYTLLEQGLDRVDVMQFLDHVQAGLCDHYDIKMLTYLMTARLAILCPDKVLLRLDQFI 1162
            ||||||||||||:..|||:|:.:||:||:.||.|||||||||:||..||:.|||..||.|||:.:
Human  1082 RKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLV 1146

  Fly  1163 QQLRDTCTHKVKANSVKQEYEKQDELKRSALRAVSALSQIPKANKNQQLVDFLKSIKETPELNKI 1227
            :.||.|||.||||||||||:||||||||||:|||:||..||:|.|:..:.:|...|...|||..|
Human  1147 EPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAI 1211

  Fly  1228 FEYIQKDSITGSSDIIVMDQS 1248
            ||.|||||  .|:::..||.|
Human  1212 FESIQKDS--SSTNLESMDTS 1230

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cand1NP_001260333.1 HEAT repeat 9..33 CDD:293787 21/23 (91%)
HEAT repeat 50..78 CDD:293787 25/27 (93%)
HEAT repeat 87..118 CDD:293787 24/30 (80%)
HEAT repeat 132..158 CDD:293787 17/26 (65%)
HEAT_EZ 147..200 CDD:290247 34/52 (65%)
HEAT repeat 171..200 CDD:293787 18/28 (64%)
HEAT repeat 212..242 CDD:293787 13/29 (45%)
HEAT repeat 253..277 CDD:293787 10/23 (43%)
HEAT repeat 513..538 CDD:293787 15/24 (63%)
HEAT repeat 545..569 CDD:293787 9/23 (39%)
HEAT repeat 609..636 CDD:293787 19/26 (73%)
HEAT repeat 647..676 CDD:293787 14/28 (50%)
HEAT repeat 982..1011 CDD:293787 15/28 (54%)
HEAT repeat 1022..1050 CDD:293787 17/27 (63%)
TIP120 1056..1218 CDD:285787 113/161 (70%)
CAND1NP_060918.2 HEAT 1 2..39 32/37 (86%)
HEAT repeat 11..32 CDD:293787 19/20 (95%)
HEAT 2 44..81 31/36 (86%)
HEAT repeat 53..74 CDD:293787 19/20 (95%)
HEAT 3 83..119 29/35 (83%)
HEAT repeat 87..119 CDD:293787 25/31 (81%)
HEAT repeat 129..164 CDD:293787 23/34 (68%)
HEAT 4 131..165 22/33 (67%)
HEAT_EZ 150..202 CDD:404407 33/51 (65%)
HEAT 5 171..208 20/36 (56%)
HEAT repeat 175..201 CDD:293787 17/25 (68%)
HEAT 6 210..247 16/36 (44%)
HEAT repeat 211..243 CDD:293787 13/31 (42%)
HEAT 7 248..282 13/33 (39%)
HEAT repeat 255..285 CDD:293787 14/29 (48%)
HEAT 8 289..366 45/77 (58%)
HEAT repeat 296..359 CDD:293787 40/63 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 315..344 13/29 (45%)
HEAT 9 370..407 26/36 (72%)
HEAT repeat 372..397 CDD:293787 18/24 (75%)
HEAT 10 424..467 23/42 (55%)
HEAT 11 471..510 20/38 (53%)
HEAT 12 515..552 26/36 (72%)
HEAT 13 563..602 21/38 (55%)
HEAT repeat 573..600 CDD:293787 18/26 (69%)
HEAT 14 606..643 23/36 (64%)
HEAT repeat 610..638 CDD:293787 20/27 (74%)
HEAT 15 646..683 17/36 (47%)
HEAT repeat 647..676 CDD:293787 14/28 (50%)
HEAT 16 688..725 14/36 (39%)
HEAT repeat 690..719 CDD:293787 12/28 (43%)
HEAT 17 729..768 20/38 (53%)
HEAT 18 770..808 20/51 (39%)
HEAT 19 809..845 9/35 (26%)
HEAT repeat 817..847 CDD:293787 8/29 (28%)
HEAT 20 852..889 18/36 (50%)
HEAT repeat 856..886 CDD:293787 15/29 (52%)
HEAT 21 890..927 26/41 (63%)
HEAT repeat 894..918 CDD:293787 17/23 (74%)
HEAT 22 928..960 23/31 (74%)
HEAT repeat 929..958 CDD:293787 21/28 (75%)
HEAT 23 961..998 18/36 (50%)
HEAT 24 1002..1039 24/36 (67%)
TIP120 1040..1202 CDD:400789 113/161 (70%)
HEAT 25 1043..1097 45/53 (85%)
HEAT 26 1099..1133 21/33 (64%)
HEAT 27 1140..1189 35/48 (73%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160103
Domainoid 1 1.000 1142 1.000 Domainoid score I18
eggNOG 1 0.900 - - E1_KOG1824
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H10202
Inparanoid 1 1.050 1393 1.000 Inparanoid score I122
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54621
OrthoDB 1 1.010 - - D194023at2759
OrthoFinder 1 1.000 - - FOG0002423
OrthoInspector 1 1.000 - - otm41296
orthoMCL 1 0.900 - - OOG6_101666
Panther 1 1.100 - - O PTHR12696
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3173
SonicParanoid 1 1.000 - - X1835
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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