DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cand1 and cand1

DIOPT Version :9

Sequence 1:	NP_001260333.1	Gene:	Cand1 / 34403	FlyBaseID:	FBgn0027568	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_998650.1	Gene:	cand1 / 406806	ZFINID:	ZDB-GENE-040426-2872	Length:	1230	Species:	Danio rerio

Alignment Length:	1256	Identity:	727/1256 - (57%)
Similarity:	938/1256 - (74%)	Gaps:	34/1256 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASHQYHQIANLLEKMTSTDKDFRFMATNDLMTELQKDSIILDDESEKKVVRMVLKLLEDKNGEV 65
            |||..|| |:|||||:||:|||||||||||||:|||||||.|||:||:|||:|:|||||||||||
Zfish     1 MASASYH-ISNLLEKVTSSDKDFRFMATNDLMSELQKDSIKLDDDSERKVVKMILKLLEDKNGEV 64

  Fly    66 QNLAVKCLGPLVNKVKEIQVETIVDSLCANMMSNTEQLRDISSIGLKTVIAELP--QSSNSLAPN 128
            ||||||||||||:||||.|||||||:||.||:|:.|||||||||||||||.|||  .|.::||.:
Zfish    65 QNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAAS 129

  Fly   129 VCQRITGKLSTAIEK-EDVSVKLESLDILADLLSRFGEFLVPFHSTILKALMPQLASSRQAVRKR 192
            ||::|||:|::||.| |||||:||:|||:||:|.|.|..||.||.:||..|:|||.|.|.|||||
Zfish   130 VCKKITGRLTSAIAKQEDVSVQLEALDIMADMLCRQGGLLVNFHPSILSCLLPQLTSPRLAVRKR 194

  Fly   193 TIVALSFLLIQANSNAYNGVIDHLLDGLENPPNPAAIRTYIQCLASICRQAGHRLCNHIDRSMLL 257
            ||:||..|::...:..:..:|:|||..|....:.:..||||||:|:|.||||||:..::::.:.|
Zfish   195 TIIALGHLVMSCGNLVFVDLIEHLLSELSRNESMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPL 259

  Fly   258 LSQYSQRDDDELREFCLQACEAFVMRCPDAINPHIPMILELCLNYITYDPNYNYETDDGDTGNAM 322
            :.::...|||||||:|:||.|:||.|||..:.||:|.::.:||.|:||||||||:.:|.|. |||
Zfish   260 VVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVPTVISICLKYLTYDPNYNYDDEDEDE-NAM 323

  Fly   323 DTE--DDEYVDS-EEYSDDDDMSWKVRRAAAKCLEVLISTRQELVEDFYRSLSPALIARFKEREE 384
            |.:  |::|..| :||||||||||||||||||||:.::|||.|::.:|||::|||||||||||||
Zfish   324 DADGVDEDYQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYRTVSPALIARFKEREE 388

  Fly   385 NVKSDIFHAYVALLKNTRLTDDVANDHDSMDQVSGPTSLLIEQLPLIVKAIQPLMREKSMKTRQD 449
            |||:|:||||::|||.||.......|.|:|:|...|.::|..|:.:||||:...|:|||:||||.
Zfish   389 NVKADVFHAYLSLLKQTRPAQSWLCDPDAMEQGETPLTMLQSQVSMIVKALHKQMKEKSVKTRQC 453

  Fly   450 CFLLLRELLNSLPGALGPYLDSIVPGISYSLNDKSSTSNMKIESLGFLYSLLQGHPPHVFHPHIP 514
            ||.:|.||:|.|||||..::..::|||.:|||||||:||:||::|..||.:|..|.|.|||||:.
Zfish   454 CFNMLTELVNVLPGALTQHIPVLIPGIIFSLNDKSSSSNLKIDALSCLYVILCNHQPQVFHPHVQ 518

  Fly   515 LLVPLVVTSVFDPFYKIATEALLVLQQLVKVIRPLEPNAAKSDFDAPSFVGQVYSCTLQKLKVTD 579
            .:||.||..|.||||||.:|||||.||||||||||:...|   |||..::..:::|.:::||..|
Zfish   519 AIVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLDQTDA---FDASPYITDLFACIIKRLKAAD 580

  Fly   580 VDQEVKERAIACMGQIIANMGDMLQNELAVCLPIFMERLKNEVTRLSSVKALTLIAASSLRIDLT 644
            :|||||||||:||||||.|:||.|..:|...|.||:||||||:|||::||||||||.|.|:|:|.
Zfish   581 IDQEVKERAISCMGQIICNLGDGLGADLPGTLHIFLERLKNEITRLTTVKALTLIAGSPLKINLR 645

  Fly   645 PILHDVLPALGTFLRKNHRALKLHSLDLINKIVINYSSNFEANLLQTAIVEIPPLISDSDLHVAQ 709
            |||.:.:|.|.:|||||.|||||.:|..::.:|.|||.:....::...:.|:||||::||:||:|
Zfish   646 PILGEAVPILASFLRKNQRALKLSTLAALDILVKNYSDSVTPAMIDAVLAELPPLINESDMHVSQ 710

  Fly   710 YSLTLLSTVARRQPQALVGIHEQFLRSVLILVRSPLLQGSALNCTLELFQALVQTQLSGLDYHSL 774
            .:::.|:|:||..|.:|..|....|..::.|||||||||.||:..||.|||||.|..:.|.|..|
Zfish   711 MAISFLTTLARVHPDSLSKISGSILAELIALVRSPLLQGGALSAMLEFFQALVATGTASLGYMDL 775

  Fly   775 VSKLMAPVLGGNGDVKSRATAGAPSEVVQLHKQAYHSSAKCIAALTQQCPQVATPLATKLITDLQ 839
            :..|..||.     .:|.|..         |||:|:|.|||:||||:.||:....:..:.|.|::
Zfish   776 LRMLTGPVY-----AQSAALT---------HKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVK 826

  Fly   840 KRNDTEII--FCLLTIGEIGRHFDLSSIQVLPQTIIECFGATSEDVKAAASHALGAVSVGSLQTY 902
            ....|:.|  ..||::||:|.|.||||...|...|::.|.:.||:||:|||:|||::|||:|..|
Zfish   827 NSRSTDSIRLLALLSLGEVGHHVDLSSQPELKTVILDAFSSASEEVKSAASYALGSISVGNLPEY 891

  Fly   903 LPLILHEIEVQPKRQYLLLHSLKEVISSLSVSPSGLAQLLPSVPSIWDQLFKHCECSEEGSRNVV 967
            ||.:|.||..||||||||||||||:|||.||     |.|.|.|.::|..|.|||||:|||:||||
Zfish   892 LPFVLQEISGQPKRQYLLLHSLKEIISSASV-----AGLKPYVENVWALLLKHCECTEEGTRNVV 951

  Fly   968 AECLGKLVLVNPDELLPQLQQALRSESATMRTVVVSSVKFTISDQPQPIDVLLKQNIGEFLFALR 1032
            |||||||.|::|:.|||:|:..|.|.|:..|:.||::|:|||||.||.||.|||..||:||..|.
Zfish   952 AECLGKLTLIDPETLLPRLKGYLLSGSSYARSSVVTAVRFTISDHPQTIDPLLKNCIGDFLKTLE 1016

  Fly  1033 DPEPQVRRVALVAFNSAVHNKPSLVRDLLPTLLPWLYSETKVKSELIREVEMGPFKHTVDDGLDI 1097
            ||:..|||||||.|:||.||||||:||||.|:||.||:||||:.|||||||||||||||||||||
Zfish  1017 DPDLNVRRVALVTFSSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDI 1081

  Fly  1098 RKAAFECMYTLLEQGLDRVDVMQFLDHVQAGLCDHYDIKMLTYLMTARLAILCPDKVLLRLDQFI 1162
            ||||||||||||:..|||:|:.:||:||:.||.|||||||||:||.|||:.|||..||.|||:.:
Zfish  1082 RKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLARLSSLCPSAVLQRLDRLV 1146

  Fly  1163 QQLRDTCTHKVKANSVKQEYEKQDELKRSALRAVSALSQIPKANKNQQLVDFLKSIKETPELNKI 1227
            :.|..|||.||||||||||:||||||||||:|||.||..||:|.|:..:.:|...|...|||..|
Zfish  1147 EPLGATCTTKVKANSVKQEFEKQDELKRSAMRAVVALLTIPEAEKSPLMSEFQSQISSNPELAAI 1211

  Fly  1228 FEYIQKDSITGSSDIIVMDQS 1248
            |:.||:||  .|:::..||.|
Zfish  1212 FDSIQRDS--SSTNMESMDTS 1230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cand1	NP_001260333.1	HEAT repeat	9..33	CDD:293787	20/23 (87%)
		HEAT repeat	50..78	CDD:293787	25/27 (93%)
		HEAT repeat	87..118	CDD:293787	24/30 (80%)
		HEAT repeat	132..158	CDD:293787	17/26 (65%)
		HEAT_EZ	147..200	CDD:290247	33/52 (63%)
		HEAT repeat	171..200	CDD:293787	18/28 (64%)
		HEAT repeat	212..242	CDD:293787	13/29 (45%)
		HEAT repeat	253..277	CDD:293787	10/23 (43%)
		HEAT repeat	513..538	CDD:293787	14/24 (58%)
		HEAT repeat	545..569	CDD:293787	9/23 (39%)
		HEAT repeat	609..636	CDD:293787	19/26 (73%)
		HEAT repeat	647..676	CDD:293787	14/28 (50%)
		HEAT repeat	982..1011	CDD:293787	14/28 (50%)
		HEAT repeat	1022..1050	CDD:293787	16/27 (59%)
		TIP120	1056..1218	CDD:285787	113/161 (70%)
cand1	NP_998650.1	HEAT repeat	53..74	CDD:293787	19/20 (95%)
		HEAT repeat	87..119	CDD:293787	25/31 (81%)
		HEAT repeat	129..161	CDD:293787	20/31 (65%)
		HEAT_EZ	149..202	CDD:290247	33/52 (63%)
		HEAT repeat	175..201	CDD:293787	17/25 (68%)
		HEAT repeat	211..243	CDD:293787	13/31 (42%)
		HEAT repeat	255..285	CDD:293787	14/29 (48%)
		HEAT repeat	296..359	CDD:293787	40/63 (63%)
		HEAT repeat	372..397	CDD:293787	20/24 (83%)
		Vac14_Fab1_bd	<515..586	CDD:289521	39/73 (53%)
		HEAT repeat	572..600	CDD:293787	18/27 (67%)
		HEAT repeat	610..638	CDD:293787	20/27 (74%)
		HEAT repeat	647..676	CDD:293787	15/28 (54%)
		ARM	650..745	CDD:237987	38/94 (40%)
		HEAT repeat	690..719	CDD:293787	11/28 (39%)
		HEAT repeat	817..847	CDD:293787	8/29 (28%)
		HEAT	833..>1031	CDD:224331	117/202 (58%)
		HEAT repeat	856..886	CDD:293787	14/29 (48%)
		HEAT repeat	890..918	CDD:293787	20/27 (74%)
		HEAT repeat	929..958	CDD:293787	20/28 (71%)
		HEAT repeat	966..991	CDD:293787	11/24 (46%)
		HEAT repeat	1004..1032	CDD:293787	17/27 (63%)
		TIP120	1040..1202	CDD:285787	113/161 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596422
Domainoid	1	1.000	1141	1.000	Domainoid score	I18
eggNOG	1	0.900	-	-		E1_KOG1824
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10202
Inparanoid	1	1.050	1385	1.000	Inparanoid score	I122
OMA	1	1.010	-	-		QHG54621
OrthoDB	1	1.010	-	-		D194023at2759
OrthoFinder	1	1.000	-	-		FOG0002423
OrthoInspector	1	1.000	-	-		otm25682
orthoMCL	1	0.900	-	-		OOG6_101666
Panther	1	1.100	-	-	O	PTHR12696
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3173
SonicParanoid	1	1.000	-	-		X1835
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800