DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cand1 and Cand2

DIOPT Version :9

Sequence 1:	NP_001260333.1	Gene:	Cand1 / 34403	FlyBaseID:	FBgn0027568	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	XP_006237066.1	Gene:	Cand2 / 192226	RGDID:	620480	Length:	1273	Species:	Rattus norvegicus

Alignment Length:	1285	Identity:	645/1285 - (50%)
Similarity:	880/1285 - (68%)	Gaps:	79/1285 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IANLLEKMTSTDKDF--------------------------------------RFMATNDLMTEL 35
            |::|||||||:||||                                      |||||:|||:||
  Rat     8 ISSLLEKMTSSDKDFSPKSLGGSRVLDPLPWLQILAAITDWISGDRTQDLALPRFMATSDLMSEL 72

  Fly    36 QKDSIILDDESEKKVVRMVLKLLEDKNGEVQNLAVKCLGPLVNKVKEIQVETIVDSLCANMMSNT 100
            |||||.||::||:||||.:|:||||::|||||||||||||||.||||.|||.|||:|||||.|:.
  Rat    73 QKDSIQLDEDSERKVVRTLLRLLEDRSGEVQNLAVKCLGPLVGKVKEYQVENIVDTLCANMRSDK 137

  Fly   101 EQLRDISSIGLKTVIAELPQSS--NSLAPNVCQRITGKLSTAI-EKEDVSVKLESLDILADLLSR 162
            ||||||:.||||||::|||.::  :.||.:||::|||:|::|| ::|||:|:||:||||:|:|||
  Rat   138 EQLRDIAGIGLKTVLSELPPAATGSGLAISVCRKITGQLTSAIAQQEDVAVQLEALDILSDMLSR 202

  Fly   163 FGEFLVPFHSTILKALMPQLASSRQAVRKRTIVALSFLLIQANSNAYNGVIDHLLD---GLENPP 224
            .|..|..||:::|..|:|||:|.|.||||||:|||..|....:::.:..:.|||:|   |...|.
  Rat   203 LGAPLGTFHASLLHCLLPQLSSPRLAVRKRTVVALGHLAAACSTDLFVELADHLVDRLPGPRAPA 267

  Fly   225 NPAAIRTYIQCLASICRQAGHRLCNHIDRSMLLLSQYSQRDDDELREFCLQACEAFVMRCPDAIN 289
            :||||||.||||.|:.|||||||..|:||.|.|:.::...|||||||.||||.|||:.:||..::
  Rat   268 SPAAIRTLIQCLGSVGRQAGHRLGAHLDRLMPLVEEFCNLDDDELRESCLQAFEAFLRKCPKEMD 332

  Fly   290 PHIPMILELCLNYITYDPNYNYETDDGDTGNAMDTEDDEYVDSE---EYSDDDDMSWKVRRAAAK 351
            ||:|.:..|||.|:.:|||||:::|:.:   .|:|||.|:.:.|   ||||||||||||||||||
  Rat   333 PHVPNVTSLCLQYMKHDPNYNHDSDEEE---QMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAK 394

  Fly   352 CLEVLISTRQELVEDFYRSLSPALIARFKEREENVKSDIFHAYVALLKNTRLTDDVANDHDSMDQ 416
            |:..|||:|.:|:.||:.:|:||||.||||||||||:|||.||:.||::||.........:...|
  Rat   395 CMAALISSRPDLLPDFHCTLAPALIRRFKEREENVKADIFGAYIMLLRHTRPPKGWLEAVEEPTQ 459

  Fly   417 VSGPTSLLIEQLPLIVKAIQPLMREKSMKTRQDCFLLLRELLNSLPGALGPYLDSIVPGISYSLN 481
            .....::|..|:||::||:|..:::::::|||.||.|..||...|||.|..::..:|.||.:||.
  Rat   460 TGRNLNMLRAQVPLVMKALQRQLKDRNVRTRQGCFNLFTELAGVLPGCLAEHMTVLVSGIVFSLA 524

  Fly   482 DKSSTSNMKIESLGFLYSLLQGHPPHVFHPHIPLLVPLVVTSVFDPFYKIATEALLVLQQLVKVI 546
            |.||:|.:::::|.||..||...|...||||:|.|:|.|:..|.|||||:|.|||||||:||:.:
  Rat   525 DYSSSSTIRMDALAFLQGLLGTEPAEAFHPHLPTLLPPVMACVADPFYKVAAEALLVLQELVRTL 589

  Fly   547 RPLE-PNAAKSDFDAPSFVGQVYSCTLQKLKVTDVDQEVKERAIACMGQIIANMGDMLQNELAVC 610
            .||: |..    .|...:||::.:.||.:|:.||:|||||||||:|:|.::.::||.|.::|...
  Rat   590 WPLDRPRL----LDPEPYVGEMSTATLARLRATDLDQEVKERAISCVGHLVGHLGDRLGDDLEPT 650

  Fly   611 LPIFMERLKNEVTRLSSVKALTLIAASSLRIDLTPILHDVLPALGTFLRKNHRALKLHSLDLINK 675
            |.:.::||:||:|||.:||||||:|.|.||:||.|||.:.||.|.:|||||.|||:|.:|..::.
  Rat   651 LLLLLDRLRNEITRLPAVKALTLVAVSPLRLDLQPILAEALPILASFLRKNQRALRLATLAALDA 715

  Fly   676 IVINYSSNFEANLLQTAIVEIPPLISDSDLHVAQYSLTLLSTVARRQPQALVGIHEQFLRSVLIL 740
            :..:.........:::.:.|:|.|:|::|:||||.::..|:||.:.||.:||.:....|..:|.|
  Rat   716 LAQSQGLGLPPPAVRSVLAELPALVSENDMHVAQLAVDFLTTVTQTQPASLVEVSGPVLEELLQL 780

  Fly   741 VRSPLLQGSALNCTLELFQALVQTQLSGLDYHSLVSKLMAPVLGGNGDVKSRATAGAPSEVVQLH 805
            :.||||....|..|....||||.|:...::|..|:|.|.|||....||       |.|.    ||
  Rat   781 LHSPLLPAGVLAATEGFLQALVGTRPPCVEYSELISLLTAPVYNQVGD-------GGPG----LH 834

  Fly   806 KQAYHSSAKCIAALTQQCPQVATPLATKLITDLQK-RNDTEI-IFCLLTIGEIGRHFDLSSIQVL 868
            ||.:||.|:|:|||:..|||.|...|::|:.|.:. .:.|.: :...|::.|:|:.......:.|
  Rat   835 KQVFHSLARCVAALSAACPQEAAGTASRLVCDARSPHSSTGVKVLAFLSLAEVGQVAGPGPQREL 899

  Fly   869 PQTIIECFGATSEDVKAAASHALGAVSVGSLQTYLPLILHEIEVQPKRQYLLLHSLKEVISSLSV 933
            ...::|..|:.||||:|||::|||.|..|:|..:||.:|.:||.||:|||||||:|:|.:
  Rat   900 KTVLLEALGSPSEDVRAAAAYALGRVGAGNLPDFLPFLLAQIEAQPRRQYLLLHALREAL----- 959

  Fly   934 SPSGLAQ---LLPSVPSIWDQLFKHCECSEEGSRNVVAECLGKLVLVNPDELLPQLQQALRSESA 995
               |.||   |.|.|..:|..||:.||..|||:|.|||||:||||.|||..|||:.::.|.:...
  Rat   960 ---GAAQPDNLKPYVEDVWALLFQRCESPEEGTRCVVAECIGKLVFVNPPFLLPRFRKQLAAGQP 1021

  Fly   996 TMRTVVVSSVKFTISDQPQPIDVLLKQNIGEFLFALRDPEPQVRRVALVAFNSAVHNKPSLVRDL 1060
            ..|:.|:::|||.|||||..||.|||..|.||:.:|:||:..|||..|..|||||||||||||||
  Rat  1022 YTRSTVITAVKFLISDQPHSIDPLLKSFIAEFMESLQDPDLNVRRATLTFFNSAVHNKPSLVRDL 1086

  Fly  1061 LPTLLPWLYSETKVKSELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLEQGLDRVDVMQFLDHV 1125
            |..:||.||.|||::.:|||||||||||||||||||:|||||||||:|||..|.::|:.:||:||
  Rat  1087 LDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMYSLLESCLGQLDICEFLNHV 1151

  Fly  1126 QAGLCDHYDIKMLTYLMTARLAILCPDKVLLRLDQFIQQLRDTCTHKVKANSVKQEYEKQDELKR 1190
            :.||.|||||:|||::|.||||.|||..||.|:|:.|:.||.|||.||||.|||||.||||||||
  Rat  1152 EDGLKDHYDIRMLTFIMLARLAALCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQELEKQDELKR 1216

  Fly  1191 SALRAVSALSQIPKANKNQQLVDFLKSIKETPELNKIFEYIQKDSITGSS 1240
            ||:|||:||...|:..|:..:.||...|:..|||..:||.||||:.:|.|
  Rat  1217 SAMRAVAALMTNPEVRKSPSVADFSTQIRSNPELATLFESIQKDTASGPS 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cand1	NP_001260333.1	HEAT repeat	9..33	CDD:293787	19/61 (31%)
		HEAT repeat	50..78	CDD:293787	22/27 (81%)
		HEAT repeat	87..118	CDD:293787	21/30 (70%)
		HEAT repeat	132..158	CDD:293787	16/26 (62%)
		HEAT_EZ	147..200	CDD:290247	31/52 (60%)
		HEAT repeat	171..200	CDD:293787	17/28 (61%)
		HEAT repeat	212..242	CDD:293787	17/32 (53%)
		HEAT repeat	253..277	CDD:293787	13/23 (57%)
		HEAT repeat	513..538	CDD:293787	14/24 (58%)
		HEAT repeat	545..569	CDD:293787	6/24 (25%)
		HEAT repeat	609..636	CDD:293787	14/26 (54%)
		HEAT repeat	647..676	CDD:293787	14/28 (50%)
		HEAT repeat	982..1011	CDD:293787	10/28 (36%)
		HEAT repeat	1022..1050	CDD:293787	13/27 (48%)
		TIP120	1056..1218	CDD:285787	106/161 (66%)
Cand2	XP_006237066.1	HEAT repeat	49..75	CDD:293787	11/25 (44%)
		HEAT repeat	87..114	CDD:293787	21/26 (81%)
		HEAT repeat	124..154	CDD:293787	21/29 (72%)
		HEAT repeat	163..198	CDD:293787	20/34 (59%)
		HEAT_EZ	188..240	CDD:290247	31/51 (61%)
		HEAT repeat	211..240	CDD:293787	17/28 (61%)
		HEAT repeat	474..502	CDD:293787	11/27 (41%)
		HEAT repeat	510..546	CDD:293787	14/35 (40%)
		HEAT repeat	558..584	CDD:293787	16/25 (64%)
		HEAT repeat	604..635	CDD:293787	18/30 (60%)
		HEAT repeat	831..855	CDD:293787	14/27 (52%)
		HEAT repeat	902..924	CDD:293787	11/21 (52%)
		HEAT repeat	933..963	CDD:293787	17/37 (46%)
		HEAT repeat	973..1000	CDD:293787	15/26 (58%)
		HEAT repeat	1007..1033	CDD:293787	7/25 (28%)
		HEAT repeat	1046..1074	CDD:293787	13/27 (48%)
		TIP120	1095..1244	CDD:285787	97/148 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354168
Domainoid	1	1.000	1128	1.000	Domainoid score	I17
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1380	1.000	Inparanoid score	I113
OMA	1	1.010	-	-		QHG54621
OrthoDB	1	1.010	-	-		D194023at2759
OrthoFinder	1	1.000	-	-		FOG0002423
OrthoInspector	1	1.000	-	-		otm45423
orthoMCL	1	0.900	-	-		OOG6_101666
Panther	1	1.100	-	-	LDO	PTHR12696
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1835
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910