DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cand1 and Cand1

DIOPT Version :10

Sequence 1:NP_609389.1 Gene:Cand1 / 34403 FlyBaseID:FBgn0027568 Length:1248 Species:Drosophila melanogaster
Sequence 2:NP_446456.1 Gene:Cand1 / 117152 RGDID:620479 Length:1230 Species:Rattus norvegicus


Alignment Length:1256 Identity:736/1256 - (58%)
Similarity:941/1256 - (74%) Gaps:34/1256 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASHQYHQIANLLEKMTSTDKDFRFMATNDLMTELQKDSIILDDESEKKVVRMVLKLLEDKNGEV 65
            |||..|| |:||||||||:|||||||||||||||||||||.|||:||:|||:|:|||||||||||
  Rat     1 MASASYH-ISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEV 64

  Fly    66 QNLAVKCLGPLVNKVKEIQVETIVDSLCANMMSNTEQLRDISSIGLKTVIAELP--QSSNSLAPN 128
            ||||||||||||:||||.|||||||:||.||:|:.|||||||||||||||.|||  .|.::||.|
  Rat    65 QNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAAN 129

  Fly   129 VCQRITGKLSTAIEK-EDVSVKLESLDILADLLSRFGEFLVPFHSTILKALMPQLASSRQAVRKR 192
            ||::|||:|::||.| |||||:||:|||:||:|||.|..||.||.:||..|:|||.|.|.|||||
  Rat   130 VCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKR 194

  Fly   193 TIVALSFLLIQANSNAYNGVIDHLLDGLENPPNPAAIRTYIQCLASICRQAGHRLCNHIDRSMLL 257
            ||:||..|::...:..:..:|:|||..|....:.:..||||||:|:|.||||||:..::::.:.|
  Rat   195 TIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPL 259

  Fly   258 LSQYSQRDDDELREFCLQACEAFVMRCPDAINPHIPMILELCLNYITYDPNYNYETDDGDTGNAM 322
            :.::...|||||||:|:||.|:||.|||..:.||:..|:.:||.|:||||||||:.:|.|. |||
  Rat   260 VVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDE-NAM 323

  Fly   323 DT---EDDEYVDSEEYSDDDDMSWKVRRAAAKCLEVLISTRQELVEDFYRSLSPALIARFKEREE 384
            |.   :||:....:||||||||||||||||||||:.::|||.|::.:||:::|||||:|||||||
  Rat   324 DADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREE 388

  Fly   385 NVKSDIFHAYVALLKNTRLTDDVANDHDSMDQVSGPTSLLIEQLPLIVKAIQPLMREKSMKTRQD 449
            |||:|:||||::|||.||.......|.|:|:|...|.::|..|:|.||||:...|:|||:||||.
  Rat   389 NVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQC 453

  Fly   450 CFLLLRELLNSLPGALGPYLDSIVPGISYSLNDKSSTSNMKIESLGFLYSLLQGHPPHVFHPHIP 514
            ||.:|.||:|.|||||..::..:||||.:|||||||:||:||::|..||.:|..|.|.|||||:.
  Rat   454 CFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQ 518

  Fly   515 LLVPLVVTSVFDPFYKIATEALLVLQQLVKVIRPLEPNAAKSDFDAPSFVGQVYSCTLQKLKVTD 579
            .|||.||..|.||||||.:|||||.||||||||||:   ..|.|||..::..:::||:::||..|
  Rat   519 ALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLD---QPSSFDATPYIKDLFTCTIKRLKAAD 580

  Fly   580 VDQEVKERAIACMGQIIANMGDMLQNELAVCLPIFMERLKNEVTRLSSVKALTLIAASSLRIDLT 644
            :|||||||||:||||||.|:||.|..:|:..|.||:||||||:|||::||||||||.|.|:|||.
  Rat   581 IDQEVKERAISCMGQIICNLGDNLGPDLSNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLR 645

  Fly   645 PILHDVLPALGTFLRKNHRALKLHSLDLINKIVINYSSNFEANLLQTAIVEIPPLISDSDLHVAQ 709
            |:|.:.:|.|.:|||||.|||||.:|..::.::.|||.:..|.::...:.|:|||||:||:||:|
  Rat   646 PVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQ 710

  Fly   710 YSLTLLSTVARRQPQALVGIHEQFLRSVLILVRSPLLQGSALNCTLELFQALVQTQLSGLDYHSL 774
            .:::.|:|:|:..|.:|..|....|..::.|||||||||.||:..|:.|||||.|..:.|.|..|
  Rat   711 MAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDL 775

  Fly   775 VSKLMAPVLGGNGDVKSRATAGAPSEVVQLHKQAYHSSAKCIAALTQQCPQVATPLATKLITDLQ 839
            :..|..||.       |::||       ..|||:|:|.|||:||||:.||:....:..:.|.|::
  Rat   776 LRMLTGPVY-------SQSTA-------LTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVK 826

  Fly   840 KRNDTEII--FCLLTIGEIGRHFDLSSIQVLPQTIIECFGATSEDVKAAASHALGAVSVGSLQTY 902
            ....|:.|  ..||::||:|.|.|||....|...|:|.|.:.||:||:|||:|||::|||:|..|
  Rat   827 NSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEY 891

  Fly   903 LPLILHEIEVQPKRQYLLLHSLKEVISSLSVSPSGLAQLLPSVPSIWDQLFKHCECSEEGSRNVV 967
            ||.:|.||..||||||||||||||:|||.||     ..|.|.|.:||..|.|||||:|||:||||
  Rat   892 LPFVLQEITSQPKRQYLLLHSLKEIISSASV-----VGLKPYVENIWALLLKHCECAEEGTRNVV 951

  Fly   968 AECLGKLVLVNPDELLPQLQQALRSESATMRTVVVSSVKFTISDQPQPIDVLLKQNIGEFLFALR 1032
            |||||||.|::|:.|||:|:..|.|.|:..|:.||::|||||||.|||||.|||..||:||..|.
  Rat   952 AECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLE 1016

  Fly  1033 DPEPQVRRVALVAFNSAVHNKPSLVRDLLPTLLPWLYSETKVKSELIREVEMGPFKHTVDDGLDI 1097
            ||:..|||||||.||||.||||||:||||.::||.||:||||:.|||||||||||||||||||||
  Rat  1017 DPDLNVRRVALVTFNSAAHNKPSLIRDLLDSVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDI 1081

  Fly  1098 RKAAFECMYTLLEQGLDRVDVMQFLDHVQAGLCDHYDIKMLTYLMTARLAILCPDKVLLRLDQFI 1162
            ||||||||||||:..|||:|:.:||:||:.||.|||||||||:||..||:.|||..||.|||:.:
  Rat  1082 RKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLV 1146

  Fly  1163 QQLRDTCTHKVKANSVKQEYEKQDELKRSALRAVSALSQIPKANKNQQLVDFLKSIKETPELNKI 1227
            :.||.|||.||||||||||:||||||||||:|||:||..||:|.|:..:.:|...|...|||..|
  Rat  1147 EPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAI 1211

  Fly  1228 FEYIQKDSITGSSDIIVMDQS 1248
            ||.|||||  .|:::..||.|
  Rat  1212 FESIQKDS--SSTNLESMDTS 1230

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cand1NP_609389.1 HEAT repeat 9..33 CDD:293787 21/23 (91%)
HEAT repeat 50..78 CDD:293787 25/27 (93%)
HEAT repeat 87..118 CDD:293787 24/30 (80%)
HEAT repeat 132..158 CDD:293787 17/26 (65%)
HEAT_EZ 147..200 CDD:463906 34/52 (65%)
HEAT repeat 171..200 CDD:293787 18/28 (64%)
HEAT repeat 212..242 CDD:293787 13/29 (45%)
HEAT repeat 253..277 CDD:293787 10/23 (43%)
HEAT repeat 513..538 CDD:293787 15/24 (63%)
HEAT repeat 545..569 CDD:293787 9/23 (39%)
HEAT repeat 609..636 CDD:293787 19/26 (73%)
HEAT repeat 647..676 CDD:293787 14/28 (50%)
HEAT repeat 982..1011 CDD:293787 15/28 (54%)
HEAT repeat 1022..1050 CDD:293787 17/27 (63%)
TIP120 1056..1210 CDD:430111 111/153 (73%)
Cand1NP_446456.1 HEAT 1 2..39 31/36 (86%)
HEAT repeat 11..32 CDD:293787 19/20 (95%)
HEAT 2 44..81 31/36 (86%)
HEAT repeat 53..74 CDD:293787 19/20 (95%)
HEAT 3 83..119 28/35 (80%)
HEAT repeat 87..119 CDD:293787 25/31 (81%)
HEAT repeat 129..164 CDD:293787 24/35 (69%)
HEAT 4 131..165 22/34 (65%)
HEAT_EZ 149..202 CDD:463906 33/52 (63%)
HEAT 5 171..208 19/36 (53%)
HEAT repeat 175..201 CDD:293787 16/25 (64%)
HEAT 6 210..247 18/36 (50%)
HEAT repeat 211..243 CDD:293787 14/31 (45%)
HEAT 7 248..282 13/33 (39%)
HEAT repeat 255..285 CDD:293787 15/29 (52%)
HEAT 8 289..366 46/79 (58%)
HEAT repeat 296..359 CDD:293787 39/65 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 315..344 17/31 (55%)
HEAT 9 370..407 25/36 (69%)
HEAT repeat 372..397 CDD:293787 20/24 (83%)
HEAT 10 424..467 26/42 (62%)
HEAT 11 471..510 22/38 (58%)
HEAT 12 515..552 27/36 (75%)
HEAT 13 563..602 22/38 (58%)
HEAT repeat 573..600 CDD:293787 19/26 (73%)
HEAT 14 606..643 24/36 (67%)
HEAT repeat 610..638 CDD:293787 20/27 (74%)
HEAT 15 646..683 17/36 (47%)
HEAT repeat 647..676 CDD:293787 14/28 (50%)
HEAT 16 688..725 15/36 (42%)
HEAT repeat 690..719 CDD:293787 13/28 (46%)
HEAT 17 729..768 20/38 (53%)
HEAT 18 770..808 10/37 (27%)
HEAT 19 809..845 13/35 (37%)
HEAT repeat 817..847 CDD:293787 9/29 (31%)
HEAT 20 852..889 17/36 (47%)
HEAT repeat 856..886 CDD:293787 13/29 (45%)
HEAT 21 890..927 26/36 (72%)
HEAT repeat 894..918 CDD:293787 14/23 (61%)
HEAT 22 928..960 16/31 (52%)
HEAT repeat 929..958 CDD:293787 13/28 (46%)
HEAT 23 961..998 22/36 (61%)
HEAT 24 1002..1039 23/36 (64%)
TIP120 1040..1202 CDD:430111 121/161 (75%)
HEAT 25 1043..1097 43/53 (81%)
HEAT 26 1099..1133 22/33 (67%)
HEAT 27 1140..1189 32/48 (67%)

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