DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cand1 and cand1

DIOPT Version :9

Sequence 1:	NP_001260333.1	Gene:	Cand1 / 34403	FlyBaseID:	FBgn0027568	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_001182702.1	Gene:	cand1 / 100485277	XenbaseID:	XB-GENE-488480	Length:	1230	Species:	Xenopus tropicalis

Alignment Length:	1254	Identity:	732/1254 - (58%)
Similarity:	933/1254 - (74%)	Gaps:	34/1254 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASHQYHQIANLLEKMTSTDKDFRFMATNDLMTELQKDSIILDDESEKKVVRMVLKLLEDKNGEV 65
            |||..|| |:||||||||:|||||||||||||||||||||.|||:||:|||:|:|||||||||||
Frog     1 MASASYH-ISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEV 64

  Fly    66 QNLAVKCLGPLVNKVKEIQVETIVDSLCANMMSNTEQLRDISSIGLKTVIAELP--QSSNSLAPN 128
            ||||||||||||:||||.|||||||:||.||:|:.|||||||||||||||.|||  .|.::||.|
Frog    65 QNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAAN 129

  Fly   129 VCQRITGKLSTAIEK-EDVSVKLESLDILADLLSRFGEFLVPFHSTILKALMPQLASSRQAVRKR 192
            ||::|||:|::||.| |||||:||:|||:||:|||.|..||.||.:||..|:|||.|.|.|||||
Frog   130 VCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILSCLLPQLTSPRLAVRKR 194

  Fly   193 TIVALSFLLIQANSNAYNGVIDHLLDGLENPPNPAAIRTYIQCLASICRQAGHRLCNHIDRSMLL 257
            ||:||..|::...:..:..:|:|||..|....:.:..||||||:|:|.||||||:..::::.:.|
Frog   195 TIIALGHLVMSCGNIVFIDLIEHLLTELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPL 259

  Fly   258 LSQYSQRDDDELREFCLQACEAFVMRCPDAINPHIPMILELCLNYITYDPNYNYETDDGDTGNAM 322
            :.::...|||||||:|:||.|:||.|||..:.||:..|:.:||.|:||||||||:.:|.|. |||
Frog   260 VVKFCNIDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDE-NAM 323

  Fly   323 D---TEDDEYVDSEEYSDDDDMSWKVRRAAAKCLEVLISTRQELVEDFYRSLSPALIARFKEREE 384
            |   .:||:....:||||||||||||||||||||:.::|||.|::.:||:::|||||:|||||||
Frog   324 DADGADDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLAEFYKTVSPALISRFKEREE 388

  Fly   385 NVKSDIFHAYVALLKNTRLTDDVANDHDSMDQVSGPTSLLIEQLPLIVKAIQPLMREKSMKTRQD 449
            |||:|:||||::|||.||.......|.|:|:|...|.::|..|:|.||||:...|:|||:||||.
Frog   389 NVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQC 453

  Fly   450 CFLLLRELLNSLPGALGPYLDSIVPGISYSLNDKSSTSNMKIESLGFLYSLLQGHPPHVFHPHIP 514
            ||.:|.||:|.|||||..::..:||||.:|||||||:||:||::|..||.:|..|.|.|||||:.
Frog   454 CFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQ 518

  Fly   515 LLVPLVVTSVFDPFYKIATEALLVLQQLVKVIRPLEPNAAKSDFDAPSFVGQVYSCTLQKLKVTD 579
            .||..||..|.||||||.:|||||.||||||||||:   ..|.|||..::..:::||:::||..|
Frog   519 ALVSPVVICVGDPFYKITSEALLVTQQLVKVIRPLD---QPSSFDAAPYIKDLFTCTIKRLKAAD 580

  Fly   580 VDQEVKERAIACMGQIIANMGDMLQNELAVCLPIFMERLKNEVTRLSSVKALTLIAASSLRIDLT 644
            :|||||||||:||||||.::||.|.::|...|.||:||||||:|||::||||||||.|.|:|||.
Frog   581 IDQEVKERAISCMGQIICSLGDNLGSDLPSTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLR 645

  Fly   645 PILHDVLPALGTFLRKNHRALKLHSLDLINKIVINYSSNFEANLLQTAIVEIPPLISDSDLHVAQ 709
            |||.:.:|.|.:|||||.|||||.:|..::.::.|||.:..|.::...:.|:|||||:||:||:|
Frog   646 PILGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQ 710

  Fly   710 YSLTLLSTVARRQPQALVGIHEQFLRSVLILVRSPLLQGSALNCTLELFQALVQTQLSGLDYHSL 774
            .:::.|:|:|:..|.:|..|....|..:..|||||||||.||:..||.|||||.|....|.|..|
Frog   711 MAISFLTTLAKVYPSSLSKISGSILNELNGLVRSPLLQGGALSAMLEFFQALVVTGTVSLGYMDL 775

  Fly   775 VSKLMAPVLGGNGDVKSRATAGAPSEVVQLHKQAYHSSAKCIAALTQQCPQVATPLATKLITDLQ 839
            :..|..||.             |.|..: .|||:|:|.|||:||||:.||:....:..:.|.|::
Frog   776 LRMLTGPVY-------------AQSSAL-THKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVK 826

  Fly   840 KRNDTEII--FCLLTIGEIGRHFDLSSIQVLPQTIIECFGATSEDVKAAASHALGAVSVGSLQTY 902
            ....|:.|  ..||::||:|.|.|||....|...|:|.|.:.||:||:|||:|||::|||:|..|
Frog   827 NSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEY 891

  Fly   903 LPLILHEIEVQPKRQYLLLHSLKEVISSLSVSPSGLAQLLPSVPSIWDQLFKHCECSEEGSRNVV 967
            ||.:|.||..||||||||||||||:|||.||     ..|.|.|.:||..|.||.||:|||:||||
Frog   892 LPFVLQEITSQPKRQYLLLHSLKEIISSASV-----VGLKPYVENIWSLLLKHSECAEEGTRNVV 951

  Fly   968 AECLGKLVLVNPDELLPQLQQALRSESATMRTVVVSSVKFTISDQPQPIDVLLKQNIGEFLFALR 1032
            |||||||.|::|:.|||:|:..|.:.|:..|:.||::|||||||.|||||.|||..||:||..|.
Frog   952 AECLGKLTLIDPETLLPRLKGYLAAGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLE 1016

  Fly  1033 DPEPQVRRVALVAFNSAVHNKPSLVRDLLPTLLPWLYSETKVKSELIREVEMGPFKHTVDDGLDI 1097
            ||:..|||||||.||||.||||||:||||.::||.||:||||:.|||||||||||||||||||||
Frog  1017 DPDLNVRRVALVTFNSAAHNKPSLIRDLLDSVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDI 1081

  Fly  1098 RKAAFECMYTLLEQGLDRVDVMQFLDHVQAGLCDHYDIKMLTYLMTARLAILCPDKVLLRLDQFI 1162
            ||||||||||||:..|||:|:.:||:||:.||.|||||||||:||..||:.|||..||.|||:.:
Frog  1082 RKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLV 1146

  Fly  1163 QQLRDTCTHKVKANSVKQEYEKQDELKRSALRAVSALSQIPKANKNQQLVDFLKSIKETPELNKI 1227
            :.||.|||.||||||||||:||||||||||:|||:||..||:|.|:..:.:|...|...|||..|
Frog  1147 EPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAI 1211

  Fly  1228 FEYIQKDSITGSSDIIVMD 1246
            ||.||||  |.|:.:..||
Frog  1212 FESIQKD--TSSASLESMD 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cand1	NP_001260333.1	HEAT repeat	9..33	CDD:293787	21/23 (91%)
		HEAT repeat	50..78	CDD:293787	25/27 (93%)
		HEAT repeat	87..118	CDD:293787	24/30 (80%)
		HEAT repeat	132..158	CDD:293787	17/26 (65%)
		HEAT_EZ	147..200	CDD:290247	34/52 (65%)
		HEAT repeat	171..200	CDD:293787	18/28 (64%)
		HEAT repeat	212..242	CDD:293787	13/29 (45%)
		HEAT repeat	253..277	CDD:293787	10/23 (43%)
		HEAT repeat	513..538	CDD:293787	14/24 (58%)
		HEAT repeat	545..569	CDD:293787	9/23 (39%)
		HEAT repeat	609..636	CDD:293787	19/26 (73%)
		HEAT repeat	647..676	CDD:293787	14/28 (50%)
		HEAT repeat	982..1011	CDD:293787	14/28 (50%)
		HEAT repeat	1022..1050	CDD:293787	17/27 (63%)
		TIP120	1056..1218	CDD:285787	112/161 (70%)
cand1	NP_001182702.1	HEAT repeat	11..32	CDD:293787	19/20 (95%)
		HEAT repeat	53..74	CDD:293787	19/20 (95%)
		HEAT repeat	87..119	CDD:293787	25/31 (81%)
		HEAT repeat	129..164	CDD:293787	23/34 (68%)
		HEAT_EZ	149..202	CDD:372621	34/52 (65%)
		HEAT repeat	175..201	CDD:293787	17/25 (68%)
		HEAT repeat	212..243	CDD:293787	13/30 (43%)
		HEAT repeat	255..285	CDD:293787	14/29 (48%)
		HEAT repeat	296..359	CDD:293787	40/63 (63%)
		HEAT repeat	372..397	CDD:293787	18/24 (75%)
		HEAT repeat	573..600	CDD:293787	18/26 (69%)
		HEAT repeat	610..638	CDD:293787	20/27 (74%)
		HEAT repeat	647..676	CDD:293787	15/28 (54%)
		HEAT repeat	690..719	CDD:293787	12/28 (43%)
		HEAT repeat	817..847	CDD:293787	8/29 (28%)
		HEAT repeat	856..886	CDD:293787	15/29 (52%)
		HEAT repeat	890..918	CDD:293787	20/27 (74%)
		HEAT repeat	929..958	CDD:293787	20/28 (71%)
		TIP120	1040..1202	CDD:370010	112/161 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1136	1.000	Domainoid score	I19
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10202
Inparanoid	1	1.050	1376	1.000	Inparanoid score	I131
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194023at2759
OrthoFinder	1	1.000	-	-		FOG0002423
OrthoInspector	1	1.000	-	-		otm48500
Panther	1	1.100	-	-	O	PTHR12696
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3173
SonicParanoid	1	1.000	-	-		X1835
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190