Protein Alignment CtsL4 and CTSF

DIOPT Version :10

• Sequence 1: NP_609387.1
• Gene: CtsL4 / 34401
• FlyBaseID: FBgn0032228
• Length: 338
• Species: Drosophila melanogaster
• Sequence 2: NP_003784.2
• Gene: CTSF / 8722
• HGNCID: 2531
• Length: 484
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 98/319 - (30%)
• Similarity: 160/319 - (50%)
• Gaps: 41/319 - (12%)

  Fly    39 FKNNNNRKYLRTYDEMRSYKAFEE---------NFKVIEEHNQNYKEGQTSFRLKPNIFADMSTD 94
            |||     ::.||:  |:|::.||         |..|..:..|....|...:.:..  |:|::.:
Human   187 FKN-----FVITYN--RTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTK--FSDLTEE 242

  Fly    95 G----YLKGFLRLLKSNIEDSADNMAEIVGSPLMANVPESLDWRSKGFITPPYNQLSCGSCYAFS 155
            .    ||...||....|....|.::.::        .|...||||||.:|...:|..||||:|||
Human   243 EFRTIYLNTLLRKEPGNKMKQAKSVGDL--------APPEWDWRSKGAVTKVKDQGMCGSCWAFS 299

  Fly   156 IAESIMGQVFKRTGKILSLSKQQIVDCSVSHGNQGCVGGSLRNTLSYLQSTGGIMRDQDYPYVAR 220
            :..::.||.|...|.:||||:|:::||...  ::.|:||...|..|.:::.||:..:.||.|...
Human   300 VTGNVEGQWFLNQGTLLSLSEQELLDCDKM--DKACMGGLPSNAYSAIKNLGGLETEDDYSYQGH 362

  Fly   221 KGKCQFVPDLSVVNVTSWAILPVRDEQAIQAAVTHIGPVAISINASPKTFQLYSDGIYDD--PLC 283
            ...|.|..:.:.|.:.....|. ::||.:.|.:...||::::|||.  ..|.|..||...  |||
Human   363 MQSCNFSAEKAKVYINDSVELS-QNEQKLAAWLAKRGPISVAINAF--GMQFYRHGISRPLRPLC 424

  Fly   284 SSASVNHAMVVIGFGK----DYWILKNWWGQNWGENGYIRIRKGVNMCGIANYAAYAIV 338
            |...::||::::|:|.    .:|.:||.||.:|||.||..:.:|...||:...|:.|:|
Human   425 SPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAVV 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL4	NP_609387.1	Inhibitor_I29	36..96	CDD:462410	15/69 (22%)
		Peptidase_C1A	128..336	CDD:239068	75/213 (35%)
CTSF	NP_003784.2	Inhibitor_I29	187..243	CDD:214853	15/64 (23%)
		Peptidase_C1	271..482	CDD:425470	75/215 (35%)