DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5367 and Ctsz

DIOPT Version :9

Sequence 1:	NP_609387.1	Gene:	CG5367 / 34401	FlyBaseID:	FBgn0032228	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_071720.1	Gene:	Ctsz / 64138	MGIID:	1891190	Length:	306	Species:	Mus musculus

Alignment Length:	234	Identity:	70/234 - (29%)
Similarity:	109/234 - (46%)	Gaps:	49/234 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 SPLMANVPESLDWRSKGFIT----------PPYNQLSCGSCYAFSIAESIMGQV-FKRTG---KI 171
            ||  |::|::.|||:...:.          |.|    ||||:|.....::..:: .||.|   .|
Mouse    60 SP--ADLPKNWDWRNVNGVNYASVTRNQHIPQY----CGSCWAHGSTSAMADRINIKRKGAWPSI 118

  Fly   172 LSLSKQQIVDCSVSHGNQG-CVGGSLRNTLSYLQSTG--------GIMRDQDYPYVARKGKC-QF 226
            | ||.|.::||    ||.| |.||:......|....|        ...:|||.....:.|.| :|
Mouse   119 L-LSVQNVIDC----GNAGSCEGGNDLPVWEYAHKHGIPDETCNNYQAKDQDCDKFNQCGTCTEF 178

  Fly   227 VPDLSVVNVTSWAI-----LPVRDEQAIQAAVTHIGPVAISINASPKTFQLYSDGIYDDPLCSSA 286
            ....::.|.|.|.:     |..|::  :.|.:...||::..|.|: :....|:.|||.:.. ..|
Mouse   179 KECHTIQNYTLWRVGDYGSLSGREK--MMAEIYANGPISCGIMAT-EMMSNYTGGIYAEHQ-DQA 239

  Fly   287 SVNHAMVVIGFGK-----DYWILKNWWGQNWGENGYIRI 320
            .:||.:.|.|:|.     :|||::|.||:.|||.|::||
Mouse   240 VINHIISVAGWGVSNDGIEYWIVRNSWGEPWGEKGWMRI 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5367	NP_609387.1	Inhibitor_I29	36..96	CDD:285458
CG5367	NP_609387.1	Peptidase_C1A	128..336	CDD:239068	67/227 (30%)
Ctsz	NP_071720.1	Peptidase_C1A_CathepsinX	64..305	CDD:239149	67/228 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900