Protein Alignment CtsL4 and TINAGL1

DIOPT Version :10

• Sequence 1: NP_609387.1
• Gene: CtsL4 / 34401
• FlyBaseID: FBgn0032228
• Length: 338
• Species: Drosophila melanogaster
• Sequence 2: NP_071447.1
• Gene: TINAGL1 / 64129
• HGNCID: 19168
• Length: 467
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 99/404 - (24%)
• Similarity: 149/404 - (36%)
• Gaps: 103/404 - (25%)

  Fly     9 CLCGLNCQIVTSNLSEGNSSSANCKSEFEKF-------------KNNNNRKY--LRTY------- 51
            |.|.|.|          |.:.::|..:|..|             ..:..|.|  |.||
Human    71 CYCDLFC----------NRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRC 125

  Fly    52 --DEMRSYKAFEE-------NFKVIEEHNQNYKEGQTSFRLKPNIFADMSTDGYLKGFLRLLKSN 107
              .|.|.::..:|       ..|.|.:.|..::.|..|      .|..|:.|..::..|..::.:
Human   126 TCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHS------AFWGMTLDEGIRYRLGTIRPS 184

  Fly   108 IEDSADNMAEIV-----GSPLMANVPESLDWRSKGFITPPYNQLSCGSCYAFSIAESIMGQV-FK 166
              .|..||.||.     |..|......|..|  ...|..|.:|.:|...:|||.|.....:| ..
Human   185 --SSVMNMHEIYTVLNPGEVLPTAFEASEKW--PNLIHEPLDQGNCAGSWAFSTAAVASDRVSIH 245

  Fly   167 RTGKILS-LSKQQIVDCSVSHGNQGCVGGSLRNTLSYLQSTGGIMRDQDYPYVAR---------- 220
            ..|.:.. ||.|.::.|. :|..|||.||.|.....:|:.. |::.|..||:..|
Human   246 SLGHMTPVLSPQNLLSCD-THQQQGCRGGRLDGAWWFLRRR-GVVSDHCYPFSGRERDEAGPAPP 308

  Fly   221 ---------KGKCQ---FVPDLSVVNVTSWAILPV----RDEQAIQAAVTHIGPVAISINASPKT 269
                     :||.|   ..|:..|.|...:.:.||    .:::.|...:...|||...:... :.
Human   309 CMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVH-ED 372

  Fly   270 FQLYSDGIYDDPLCSSASV-------NHAMVVIGFGKD---------YWILKNWWGQNWGENGYI 318
            |.||..|||.....|....       .|::.:.|:|::         ||...|.||..|||.|:.
Human   373 FFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHF 437

  Fly   319 RIRKGVNMCGIANY 332
            ||.:|||.|.|.::
Human   438 RIVRGVNECDIESF 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL4	NP_609387.1	Inhibitor_I29	36..96	CDD:462410	18/90 (20%)
		Peptidase_C1A	128..336	CDD:239068	67/249 (27%)
TINAGL1	NP_071447.1	Somatomedin_B	54..94	CDD:470596	8/32 (25%)
		VWC	105..>140	CDD:450195	8/34 (24%)
		Peptidase_C1A_CathepsinB	204..455	CDD:239111	67/253 (26%)