DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5367 and ctsf

DIOPT Version :9

Sequence 1:	NP_609387.1	Gene:	CG5367 / 34401	FlyBaseID:	FBgn0032228	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_001071036.1	Gene:	ctsf / 565588	ZFINID:	ZDB-GENE-030131-9831	Length:	473	Species:	Danio rerio

Alignment Length:	314	Identity:	106/314 - (33%)
Similarity:	164/314 - (52%)	Gaps:	30/314 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 FKNNNNRKYLRTYDEMRSYKAFEENFKVIEEHNQNYKEGQTSFRLKPNI-------FADMSTDGY 96
            |||     ::.||:  |:|.:.||..|.:....||.|..||...|:...       |:|::.|.:
Zfish   175 FKN-----FMITYN--RTYSSQEEAEKRLRIFQQNMKTAQTLQSLEQGSAEYGITKFSDLTEDEF 232

  Fly    97 LKGFLRLLKSNIEDSADNMAEIVGSPLMANVPESLDWRSKGFITPPYNQLSCGSCYAFSIAESIM 161
            ...:|..:.|......:....|   |..|..|::.|||..|.::|..||..||||:|||:..:|.
Zfish   233 RMMYLNPMLSQWSLKKEMKPAI---PASAPAPDTWDWRDHGAVSPVKNQGMCGSCWAFSVTGNIE 294

  Fly   162 GQVFKRTGKILSLSKQQIVDCSVSHGNQGCVGGSLRNTLSYLQSTGGIMRDQDYPYVARKGKCQF 226
            ||.||:||::||||:|::|||...  :|.|.||...|....:::.||:..:.||.|...|..|.|
Zfish   295 GQWFKKTGQLLSLSEQELVDCDKL--DQACGGGLPSNAYEAIENLGGLETETDYSYTGHKQSCDF 357

  Fly   227 VPDLSVVNVTSWAILPVRDEQAIQAAVTHIGPVAISINASPKTFQLYSDGIYDDPL---CSSASV 288
            ........:.|...|| :||:.|.|.:...|||:.::||.  ..|.|..|: ..||   |:...:
Zfish   358 STGKVAAYINSSVELP-KDEKEIAAFLAENGPVSAALNAF--AMQFYRKGV-SHPLKIFCNPWMI 418

  Fly   289 NHAMVVIGFGK----DYWILKNWWGQNWGENGYIRIRKGVNMCGIANYAAYAIV 338
            :||::::|||:    .:|.:||.||:::||.||..:.:|..:|||....:.|||
Zfish   419 DHAVLLVGFGQRNGVPFWAIKNSWGEDYGEQGYYYLYRGSGLCGIHKMCSSAIV 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5367	NP_609387.1	Inhibitor_I29	36..96	CDD:285458	19/63 (30%)
CG5367	NP_609387.1	Peptidase_C1A	128..336	CDD:239068	79/214 (37%)
ctsf	NP_001071036.1	CY	34..144	CDD:214484
		PTZ00203	143..472	CDD:185513	104/312 (33%)
		Inhibitor_I29	175..231	CDD:214853	18/62 (29%)
		Peptidase_C1	262..471	CDD:278538	78/214 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920