DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5367 and Cts7

DIOPT Version :9

Sequence 1:	NP_609387.1	Gene:	CG5367 / 34401	FlyBaseID:	FBgn0032228	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_001346316.1	Gene:	Cts7 / 56092	MGIID:	1860262	Length:	331	Species:	Mus musculus

Alignment Length:	344	Identity:	119/344 - (34%)
Similarity:	195/344 - (56%)	Gaps:	25/344 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWKLIFFGCLCGLNCQIVTSNLSEGNSSSANCKSEFEKFKNNNNRKYLRTYDEMRSYKAFEENFK 65
            |...:|...|| |...:...      :...|..:|:|::|.:|:|.| ...:|.:....:|.|.|
Mouse     1 MTPTVFLSILC-LGVALAAP------APDYNLDAEWEEWKRSNDRTY-SPEEEKQRRAVWEGNVK 57

  Fly    66 VIEEHNQNYKEGQTSFRLKPNIFADMSTDGYLKGFLRLLKSNIEDSADNMAEIVGSPLMANVPES 130
            .|::|.........:|.::.|.|.||:.:.     :::|..:......|...|  ......:|.:
Mouse    58 WIKQHIMENGLWMNNFTIEMNEFGDMTGEE-----MKMLTESSSYPLRNGKHI--QKRNPKIPPT 115

  Fly   131 LDWRSKGFITPPYNQLSCGSCYAFSIAESIMGQVFKRTGKILSLSKQQIVDCSVSHGNQGCVGGS 195
            ||||.:|::||...|.|||:|:|||:...|.||:||:|||::.||.|.::|||||:|.:||.||.
Mouse   116 LDWRKEGYVTPVRRQGSCGACWAFSVTACIEGQLFKKTGKLIPLSVQNLMDCSVSYGTKGCDGGR 180

  Fly   196 LRNTLSYLQSTGGIMRDQDYPYVARKGKCQFVPDLSVVNVTSWAILPVRDEQAIQAAVTHIGPVA 260
            ..:...|:::.||:..:..|||.|:...|::.|:.|||.|..:.::|..:|..:||.||| ||:|
Mouse   181 PYDAFQYVKNNGGLEAEATYPYEAKAKHCRYRPERSVVKVNRFFVVPRNEEALLQALVTH-GPIA 244

  Fly   261 ISINASPKTFQLYSDGIYDDPLCSSASVNHAMVVIGFG--------KDYWILKNWWGQNWGENGY 317
            ::|:.|..:|..|..|||.:|.|...:::|.::::|:|        :.||:|||..|:.||||||
Mouse   245 VAIDGSHASFHSYRGGIYHEPKCRKDTLDHGLLLVGYGYEGHESENRKYWLLKNSHGERWGENGY 309

  Fly   318 IRIRKGV-NMCGIANYAAY 335
            :::.:|. |.||||:||.|
Mouse   310 MKLPRGQNNYCGIASYAMY 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5367	NP_609387.1	Inhibitor_I29	36..96	CDD:285458	16/59 (27%)
CG5367	NP_609387.1	Peptidase_C1A	128..336	CDD:239068	93/217 (43%)
Cts7	NP_001346316.1	Inhibitor_I29	29..87	CDD:214853	16/58 (28%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18776147	33..50		5/17 (29%)
		Peptidase_C1A	113..329	CDD:239068	93/217 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830