DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5367 and ctsz

DIOPT Version :9

Sequence 1:	NP_609387.1	Gene:	CG5367 / 34401	FlyBaseID:	FBgn0032228	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_001006043.1	Gene:	ctsz / 450022	ZFINID:	ZDB-GENE-041010-139	Length:	301	Species:	Danio rerio

Alignment Length:	224	Identity:	62/224 - (27%)
Similarity:	102/224 - (45%)	Gaps:	33/224 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 MANVPESLDWRS-KG--FITPPYNQ---LSCGSCYAFSIAESIMGQV-FKRTGKILS--LSKQQI 179
            :..:|:..|||: ||  :::...||   ..||||:|.....::..:: .||.....|  ||.|.:
Zfish    51 LKELPKEWDWRNIKGVNYVSTTRNQHIPQYCGSCWAHGSTSALADRINIKRKAAWPSAYLSVQNV 115

  Fly   180 VDCSVSHGNQG-CVGGSLRNTLSYLQSTG--------GIMRDQDYPYVARKGKCQFVPDLSVV-N 234
            :||    |:.| |.||.......|..:.|        ...:|||.....:.|.|......::| |
Zfish   116 IDC----GDAGSCSGGDHSGVWEYAHNKGIPDETCNNYQAKDQDCKPFNQCGTCTTFGVCNIVKN 176

  Fly   235 VTSWAILPVRDEQAI---QAAVTHIGPVAISINASPKTFQLYSDGIYDDPLCSSASVNHAMVVIG 296
            .|.|.:........:   :|.:...||::..|.|:.| ...|:.|:|.: ......:||.:.|.|
Zfish   177 FTLWKVGDYGSASGLDKMKAEIYSGGPISCGIMATDK-LDAYTGGLYSE-YVQEPYINHIVSVAG 239

  Fly   297 FGKD-----YWILKNWWGQNWGENGYIRI 320
            :|.|     :|:::|.||:.|||.|::||
Zfish   240 WGVDENGVEFWVVRNSWGEPWGEKGWLRI 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5367	NP_609387.1	Inhibitor_I29	36..96	CDD:285458
CG5367	NP_609387.1	Peptidase_C1A	128..336	CDD:239068	62/220 (28%)
ctsz	NP_001006043.1	Peptidase_C1A_CathepsinX	54..295	CDD:239149	62/221 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910