DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5367 and ctsc

DIOPT Version :9

Sequence 1:	NP_609387.1	Gene:	CG5367 / 34401	FlyBaseID:	FBgn0032228	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_999887.1	Gene:	ctsc / 368704	ZFINID:	ZDB-GENE-030619-9	Length:	455	Species:	Danio rerio

Alignment Length:	342	Identity:	86/342 - (25%)
Similarity:	136/342 - (39%)	Gaps:	93/342 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KFKNNNNRKYLRTYDEMRSYK--------AFEENFKVIEEHNQNYKEGQTSFRLKPNIFADMSTD 94
            |....||..::   ||:.|.:        :|.|...:   |....:.|..:.|:...:
Zfish   158 KLPYTNNMMFV---DEINSVQKSWTATAYSFHETLSI---HEMLRRSGGPASRIPRRV------- 209

  Fly    95 GYLKGFLRLLKSNIEDSADNMAEIVGSPLMANVPESLDWRS---KGFITPPYNQLSCGSCYAFSI 156
                       ..:..:||:.|       .:.:|:..|||:   ..|::|..||..|||||:|:.
Zfish   210 -----------RPVTVAADSKA-------ASGLPQHWDWRNVNGVNFVSPVRNQAQCGSCYSFAT 256

  Fly   157 AESIMGQVFKRTGKILS--LSKQQIVDCSVSHGNQGCVGGSLRNTLSYLQSTGGIMRDQDYPYVA 219
            ...:..:|..:|.....  .|.||:|.|  |..:|||.||.......|:|.. ||:.:..:||..
Zfish   257 MGMLEARVRIQTNNTQQPVFSPQQVVSC--SQYSQGCDGGFPYLIGKYIQDF-GIVEEDCFPYTG 318

  Fly   220 RKGKCQFVPDLSVVNVTSWAILPVR-------------------DEQAIQAAVTHIGPVAISINA 265
            ....|.               ||.:                   .|.|:...:...||:.:::..
Zfish   319 SDSPCN---------------LPAKCTKYYASDYHYVGGFYGGCSESAMMLELVKNGPMGVALEV 368

  Fly   266 SPKTFQLYSDGIYDDPLCSSAS-----VNHAMVVIGF------GKDYWILKNWWGQNWGENGYIR 319
            .| .|..|.:|||.......|:     .|||::::|:      |:.|||:||.||..|||||:.|
Zfish   369 YP-DFMNYKEGIYHHTGLRDANNPFELTNHAVLLVGYGQCHKTGEKYWIVKNSWGSGWGENGFFR 432

  Fly   320 IRKGVNMCGIANYAAYA 336
            ||:|.:.|.|.:.|..|
Zfish   433 IRRGTDECAIESIAVAA 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5367	NP_609387.1	Inhibitor_I29	36..96	CDD:285458	11/65 (17%)
CG5367	NP_609387.1	Peptidase_C1A	128..336	CDD:239068	71/242 (29%)
ctsc	NP_999887.1	CathepsinC_exc	20..132	CDD:285926
ctsc	NP_999887.1	Peptidase_C1A_CathepsinC	224..452	CDD:239112	72/245 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920