DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5367 and CTSW

DIOPT Version :9

Sequence 1:NP_609387.1 Gene:CG5367 / 34401 FlyBaseID:FBgn0032228 Length:338 Species:Drosophila melanogaster
Sequence 2:NP_001326.3 Gene:CTSW / 1521 HGNCID:2546 Length:376 Species:Homo sapiens


Alignment Length:377 Identity:97/377 - (25%)
Similarity:153/377 - (40%) Gaps:69/377 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 CLCGLNCQIVTSNLSEG----------NSSSANCKSEFEKFKNNNNRKYLRTYDEMRSYKAFEEN 63
            ||..|    :.:.|::|          .......|..|:.|:...||.||...:.......|..|
Human     9 CLLAL----LVAGLAQGIRGPLRAQDLGPQPLELKEAFKLFQIQFNRSYLSPEEHAHRLDIFAHN 69

  Fly    64 FKVIEEHNQNYKE---GQTSFRLKPNIFADMSTD--GYLKGFLRLLKSNIEDSADNMA-EIVGSP 122
            .    ...|..:|   |...|.:.|  |:|::.:  |.|.|:.|     ......:|. ||....
Human    70 L----AQAQRLQEEDLGTAEFGVTP--FSDLTEEEFGQLYGYRR-----AAGGVPSMGREIRSEE 123

  Fly   123 LMANVPESLDWRS-KGFITPPYNQLSCGSCYAFSIAESIMGQVFKRTG--KILSLSKQQIVDCSV 184
            ...:||.|.|||. ...|:|..:|.:|..|:|.:.|.:|  :...|..  ..:.:|.|:::||  
Human   124 PEESVPFSCDWRKVASAISPIKDQKNCNCCWAMAAAGNI--ETLWRISFWDFVDVSVQELLDC-- 184

  Fly   185 SHGNQGCVGGSLRNTLSYLQSTGGIMRDQDYPY--VARKGKCQFVPDLSVVNVTSWAILPVRDEQ 247
            .....||.||.:.:....:.:..|:..::|||:  ..|..:|.......|..:..:.:|...:.:
Human   185 GRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQGKVRAHRCHPKKYQKVAWIQDFIMLQNNEHR 249

  Fly   248 AIQAAVTHIGPVAISINASPKTFQLYSDGIY--DDPLCSSASVNHAMVVIGFGK----------- 299
            ..|...|: ||:.::||..|  .|||..|:.  ....|....|:|:::::|||.           
Human   250 IAQYLATY-GPITVTINMKP--LQLYRKGVIKATPTTCDPQLVDHSVLLVGFGSVKSEEGIWAET 311

  Fly   300 -------------DYWILKNWWGQNWGENGYIRIRKGVNMCGIANYAAYAIV 338
                         .||||||.||..|||.||.|:.:|.|.|||..:...|.|
Human   312 VSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSNTCGITKFPLTARV 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5367NP_609387.1 Inhibitor_I29 36..96 CDD:285458 15/64 (23%)
Peptidase_C1A 128..336 CDD:239068 66/238 (28%)
CTSWNP_001326.3 Inhibitor_I29 42..98 CDD:214853 15/61 (25%)
Peptidase_C1A 129..358 CDD:239068 66/235 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4870
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12411
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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