Protein Alignment CtsL4 and CTSS

DIOPT Version :10

• Sequence 1: NP_609387.1
• Gene: CtsL4 / 34401
• FlyBaseID: FBgn0032228
• Length: 338
• Species: Drosophila melanogaster
• Sequence 2: NP_004070.3
• Gene: CTSS / 1520
• HGNCID: 2545
• Length: 331
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 108/314 - (34%)
• Similarity: 167/314 - (53%)
• Gaps: 33/314 - (10%)

  Fly    39 FKNNNNRKYLRTYDEMRSYKAFEENFKVIEEHNQNYKEGQTSFRLKPNIFADMSTDGYLKGFLRL 103
            :|....::|....:|......:|:|.|.:..||..:..|..|:.|..|...||:::..:.
Human    31 WKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMS----- 90

  Fly   104 LKSNIEDSADNMAEIVGSPLMANV----------PESLDWRSKGFITPPYNQLSCGSCYAFSIAE 158
            |.|::.         |.|....|:          |:|:|||.||.:|....|.|||:|:|||...
Human    91 LMSSLR---------VPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVG 146

  Fly   159 SIMGQVFKRTGKILSLSKQQIVDCSV-SHGNQGCVGGSLRNTLSYLQSTGGIMRDQDYPYVARKG 222
            ::..|:..:|||::|||.|.:||||. .:||:||.||.:.....|:....||..|..|||.|...
Human   147 ALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQ 211

  Fly   223 KCQFVPDLSVVNVTSWAILPVRDEQAIQAAVTHIGPVAISINASPKTFQLYSDGIYDDPLCSSAS 287
            |||:.........:.:..||...|..::.||.:.|||::.::|...:|.||..|:|.:|.|:. :
Human   212 KCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQ-N 275

  Fly   288 VNHAMVVIGF----GKDYWILKNWWGQNWGENGYIRI--RKGVNMCGIANYAAY 335
            |||.::|:|:    ||:||::||.||.|:||.||||:  .|| |.||||::.:|
Human   276 VNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKG-NHCGIASFPSY 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL4	NP_609387.1	Inhibitor_I29	36..96	CDD:462410	14/56 (25%)
		Peptidase_C1A	128..336	CDD:239068	89/215 (41%)
CTSS	NP_004070.3	Inhibitor_I29	28..87	CDD:214853	14/55 (25%)
		Peptidase_C1	115..329	CDD:425470	89/216 (41%)