DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5367 and Ctsl

DIOPT Version :9

Sequence 1:NP_609387.1 Gene:CG5367 / 34401 FlyBaseID:FBgn0032228 Length:338 Species:Drosophila melanogaster
Sequence 2:NP_034114.1 Gene:Ctsl / 13039 MGIID:88564 Length:334 Species:Mus musculus


Alignment Length:344 Identity:122/344 - (35%)
Similarity:199/344 - (57%) Gaps:23/344 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LIFFGCLCGLNCQIVTSNLSEGNSSSANCKSEFEKFKNNNNRKYLRTYDEMRSYKAFEENFKVIE 68
            |:....|| |...:.|....:..|      :|:.::|:.:.|.|....:|.|. ..:|:|.::|:
Mouse     4 LLLLAVLC-LGTALATPKFDQTFS------AEWHQWKSTHRRLYGTNEEEWRR-AIWEKNMRMIQ 60

  Fly    69 EHNQNYKEGQTSFRLKPNIFADMSTDGYLKGFLRLLKSNIEDSADNMAEIVGSPLMANVPESLDW 133
            .||..|..||..|.::.|.|.||:.:.:     |.:.:...........:...|||..:|:|:||
Mouse    61 LHNGEYSNGQHGFSMEMNAFGDMTNEEF-----RQVVNGYRHQKHKKGRLFQEPLMLKIPKSVDW 120

  Fly   134 RSKGFITPPYNQLSCGSCYAFSIAESIMGQVFKRTGKILSLSKQQIVDCSVSHGNQGCVGGSLRN 198
            |.||.:||..||..||||:|||.:..:.||:|.:|||::|||:|.:||||.:.|||||.||.:..
Mouse   121 REKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDF 185

  Fly   199 TLSYLQSTGGIMRDQDYPYVARKGKCQFVPDLSVVNVTSWAILPVRDEQAIQAAVTHIGPVAISI 263
            ...|::..||:..::.|||.|:.|.|::..:.:|.|.|.:..:| :.|:|:..||..:||:::::
Mouse   186 AFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIP-QQEKALMKAVATVGPISVAM 249

  Fly   264 NASPKTFQLYSDGIYDDPLCSSASVNHAMVVIGFGKD--------YWILKNWWGQNWGENGYIRI 320
            :||..:.|.||.|||.:|.|||.:::|.::::|:|.:        ||::||.||..||..|||:|
Mouse   250 DASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKI 314

  Fly   321 RKG-VNMCGIANYAAYAIV 338
            .|. .|.||:|..|:|.:|
Mouse   315 AKDRDNHCGLATAASYPVV 333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5367NP_609387.1 Inhibitor_I29 36..96 CDD:285458 18/59 (31%)
Peptidase_C1A 128..336 CDD:239068 91/216 (42%)
CtslNP_034114.1 Inhibitor_I29 29..87 CDD:214853 18/58 (31%)
Peptidase_C1 114..331 CDD:365882 91/217 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4870
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2922
OMA 1 1.010 - - QHG53545
OrthoDB 1 1.010 - - D1275401at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.780

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