Protein Alignment CtsL4 and CTSC

DIOPT Version :10

• Sequence 1: NP_609387.1
• Gene: CtsL4 / 34401
• FlyBaseID: FBgn0032228
• Length: 338
• Species: Drosophila melanogaster
• Sequence 2: NP_001805.4
• Gene: CTSC / 1075
• HGNCID: 2528
• Length: 463
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 101/368 - (27%)
• Similarity: 160/368 - (43%)
• Gaps: 82/368 - (22%)

  Fly     7 FGCLCGLNCQIVTSNLSEGNSSSANCKSEFEKFKNNNNRKYLRTYDEMRSYKAFEENFKVIEEHN 71
            :.|..|......:.|:   ..:.|:.|:..||:   :||.|...::.:::..|.::::..
Human   134 WACFTGKKVGTASENV---YVNIAHLKNSQEKY---SNRLYKYDHNFVKAINAIQKSWTA----- 187

  Fly    72 QNYKEGQTSFRLKPNIFADM--STDGYLKGFLRLLKSNIEDSADNMAEIVGSPLMANVPESLDWR 134
            ..|.|.:|.      ...||  .:.|:.:...|      ...|...|||  ...:.::|.|.|||
Human   188 TTYMEYETL------TLGDMIRRSGGHSRKIPR------PKPAPLTAEI--QQKILHLPTSWDWR 238

  Fly   135 SK---GFITPPYNQLSCGSCYAFSIAESIMGQVFKRTGKILS-------LSKQQIVDCSVSHGNQ 189
            :.   .|::|..||.||||||:|    :.||.:..|. :||:       ||.|::|.|  |...|
Human   239 NVHGINFVSPVRNQASCGSCYSF----ASMGMLEARI-RILTNNSQTPILSPQEVVSC--SQYAQ 296

  Fly   190 GCVGGSLRNTLSYL-----QSTGGIMRDQDYPYVARKGKCQFVPDLSVVNVTSW----AILPVRD 245
            ||.||     ..||     ....|::.:..:||......|:...|......:.:    ......:
Human   297 GCEGG-----FPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCN 356

  Fly   246 EQAIQAAVTHIGPVAISINASPKTFQLYSD------GIYD-----DPLCSSASVNHAMVVIGF-- 297
            |..::..:.|.||:|::       |::|.|      |||.     ||.......|||::::|:
Human   357 EALMKLELVHHGPMAVA-------FEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGT 414

  Fly   298 ----GKDYWILKNWWGQNWGENGYIRIRKGVNMCGIANYAAYA 336
                |.||||:||.||..||||||.|||:|.:.|.|.:.|..|
Human   415 DSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAA 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL4	NP_609387.1	Inhibitor_I29	36..96	CDD:462410	11/61 (18%)
		Peptidase_C1A	128..336	CDD:239068	78/243 (32%)
CTSC	NP_001805.4	CathepsinC_exc	25..138	CDD:462598	1/3 (33%)
		Peptidase_C1A_CathepsinC	231..460	CDD:239112	79/246 (32%)