DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5022 and frmd3

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001072510.1	Gene:	frmd3 / 779965	XenbaseID:	XB-GENE-1011845	Length:	585	Species:	Xenopus tropicalis

Alignment Length:	600	Identity:	183/600 - (30%)
Similarity:	283/600 - (47%)	Gaps:	78/600 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NIVYKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKS 73
            |:..:||:|||||::: ....|...||.:||:|:|....:.||||||:|:||..|||||||.||.
Frog    13 NLDMRCTIRLLDDTEI-SFNIQRDTKGQFLLDYICNHYNLLEKDYFGIRFVDPEKQRHWLDPSKP 76

  Fly    74 IIKQCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQ 137
            :.||.|...|.....||||||.:|.::... .|.:||.|:|||:.||||.|...:||.|||.|||
Frog    77 VAKQMKSHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCCFADAAFLGACIVQ 141

  Fly   138 EELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGI 202
            .|:|||:.|.|..:|:...::..:|::.||:||:|:||....||:.|::....|..|..|||||:
Frog   142 AEIGDYDPDEHPDNYICDFKIFPKQSQKLERKIVEIHKNELRGQSPSVSEFNLLLKAHSLETYGV 206

  Fly   203 DPHPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASREPKKH 267
            ||||.||..|:..::|....|...|...||....:|.:|.|:.|:||.|     :....::.||:
Frog   207 DPHPCKDSTGTTTFLGYTAAGFVVFQGNKRIHLIKWPDICKMKFDGKTF-----HVVVMQKEKKN 266

  Fly   268 TVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTEREILTENIN 332
            .:.:...|.|||::||:|.:|...|:....|.....::....|..|::|||.|:..:|::..:..
Frog   267 ILTYHTSTPAACKHLWKCGVENQAFYKYAKSSQVKTVTSSNIFFKGSRFRYCGKVAKEVVEASSK 331

  Fly   333 ALRE---------QKNNSNSSKRKASSVPATPSSP----------------QGD-----LAQIRY 367
            ..|:         ..:.|:.|..|...:...|..|                |.|     |.|...
Frog   332 IQRDPPEVHRSLIPHSRSSYSLNKQLIINMEPLQPLIPSPNEEEEEEEEENQIDEGILLLQQSEA 396

  Fly   368 SSLPRSTMSEPLGYGMPNGHFYGHDHGMSDANGGIQISSLEPVCE-EARLRSSNID-GVNYLASQ 430
            ||.|  .:......|:.......||...|.....:.||  |.|.. .|.|..:.:| |::.|.:.
Frog   397 SSAP--VLGNSPARGLETTADVTHDEEESIREEPLTIS--EQVYNPSASLLPTPVDEGIDMLFNS 457

  Fly   431 IGGYAYRDSVEHSSTESGLTVNGYDH------PRKHNEARQHGSYSPNLYYGQSDGAVNSSSPAD 489
                ..|...|...|:|...:...:|      ..:..|||:..|:|.|...|        :...:
Frog   458 ----PLRAEREKDDTDSFEDLEADEHAFLIAEEEEMKEARKALSWSYNFIMG--------NMQLN 510

  Fly   490 SFLHADPSTRKVKKFRKFHLLHAFVPSVIFVAFAMAGTAVFIMESESEA--FEQLRNSPEMLCLR 552
            :||         |.|.|..|      :.|.:...:....:.::||:.:.  ..::|.:||.....
Frog   511 AFL---------KSFSKLLL------AAIGLLMVVLPLLLILLESDIDVSFLREIRLTPEFEQFH 560

  Fly   553 YQYYQPLKEFVLEKL 567
            ::||.|.:::|..||
Frog   561 HEYYCPFRKWVACKL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	89/192 (46%)
		FERM_N	16..80	CDD:286467	32/63 (51%)
		FERM_M	108..205	CDD:278785	45/96 (47%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	37/107 (35%)
		FA	308..349	CDD:285894	11/49 (22%)
frmd3	NP_001072510.1	B41	17..209	CDD:214604	89/192 (46%)
		FERM_N	20..83	CDD:286467	32/63 (51%)
		FERM_M	101..209	CDD:278785	46/107 (43%)
		FERM_C_FRMD3_FRMD5	190..293	CDD:270013	37/107 (35%)
		FA	307..343	CDD:285894	8/35 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9050
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3009
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D227685at33208
OrthoFinder	1	1.000	-	-		FOG0002996
OrthoInspector	1	1.000	-	-		otm48940
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7059
SonicParanoid	1	1.000	-	-		X1988
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100