Protein Alignment Frmd5 and frmd5a

DIOPT Version :10

• Sequence 1: NP_609384.1
• Gene: Frmd5 / 34398
• FlyBaseID: FBgn0032225
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: XP_699526.3
• Gene: frmd5a / 570903
• ZFINID: ZDB-GENE-050419-226
• Length: 576
• Species: Danio rerio
• Alignment Length: 609
• Identity: 191/609 - (31%)
• Similarity: 271/609 - (44%)
• Gaps: 113/609 - (18%)

  Fly    12 YKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIK 76
            |.||||||||:: ..|..|...||.||.:.:|..|.:.||||||:||||..||||||:.:|||.|
Zfish    18 YMCTVRLLDDTE-YTCTIQRDAKGQYLFDLICHHLNLLEKDYFGIRYVDPDKQRHWLEFTKSISK 81

  Fly    77 QCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEEL 140
            |.|...|....|||||||.||..|... .|.:::.|:||||.||||.|...:||.|.|.|:|.|:
Zfish    82 QMKSQPPFTMCLRVKFYPPDPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAAMLAAYILQAEI 146

  Fly   141 GDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGIDPH 205
            |||:...|...|.|..:...:.:|.||::|.|:||....||....:..:||..|:.|||||:|||
Zfish   147 GDYDPGKHPEGYSSKFQFFPKHSEKLERRIAEIHKTELIGQTPETSELKFLQKAQMLETYGVDPH 211

  Fly   206 PVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASREPKKHTVG 270
            |.||..|:..::.....|.......||....:|||:.|:.||||.|  |: |.: .:|.||..:.
Zfish   212 PCKDVSGNPAFLAFTPFGFVVLQGNKRVHFLKWNEVTKLKFEGKTF--HI-YAN-QKEDKKIILT 272

  Fly   271 FKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTEREILTENINALR 335
            :..||..||::||:|.:|...|:.|..|.....:|....|..|::|||:||..:|::.::....|
Zfish   273 YFAPTPEACKHLWKCGVENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMEQSAKIKR 337

  Fly   336 EQKNNSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEPLGYGMPNGHFYGHDHGMSDANG 400
            |......:....:.|.|:....|       |.||:||:                        ...
Zfish   338 EPPEIHRAGLVPSRSCPSITHGP-------RLSSVPRT------------------------RRR 371

  Fly   401 GIQISSLEPVCEEARLRSSNIDGVNYLASQIGGYAYRDSVEHSSTESGLTVNGYDHPRKHNEARQ 465
            .:.||.:|                       |..:.|||. ||:....::......||..::...
Zfish   372 AVHISIME-----------------------GLESLRDSA-HSTPVRSVSHGDSFMPRSRSQMTD 412

  Fly   466 HG---------SYSPN---------------LYYGQSDGAVNSSSPADSFLHADPSTRKVKKF-- 504
            .|         ||||:               ....|.:||..|...........||...|.:|
Zfish   413 SGDRTAIISDESYSPSDSVLPTPVAEHSLELAVSRQINGAPCSIEEEKESEAGTPSVGDVAEFGA 477

  Fly   505 ------------RKFHLLHA-----FVPSV-------IFVAFAMAGTAVFIMESESE-AF-EQLR 543
                        |:..|..|     ||.||       |.:.|.:....:.:.||:.: || ..:|
Zfish   478 DSRAAGPMQIAGREAPLSEAEQVNKFVLSVLRLLLVTIGLLFVLLLLLIVLTESDLDIAFLRDIR 542

  Fly   544 NSPEMLCLRYQYYQPLKEFVLEKL 567
            .:||.....|:|:.||:.:...||
Zfish   543 QTPEFEQFHYEYFCPLRRWFACKL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frmd5	NP_609384.1	FERM_F1_FRMD3	12..93	CDD:340622	44/80 (55%)
		FERM_M	104..205	CDD:459788	42/100 (42%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	41/107 (38%)
		FA	308..350	CDD:462582	10/41 (24%)
frmd5a	XP_699526.3	B41	19..211	CDD:214604	91/192 (47%)
		PH-like	192..296	CDD:473070	41/107 (38%)
		FA	310..355	CDD:462582	11/44 (25%)