DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5022 and si:dkey-178k16.1

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_009294955.1	Gene:	si:dkey-178k16.1 / 569390	ZFINID:	ZDB-GENE-090312-61	Length:	1273	Species:	Danio rerio

Alignment Length:	662	Identity:	182/662 - (27%)
Similarity:	267/662 - (40%)	Gaps:	157/662 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSKNEGNIVYKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHW 67
            :||....:..|  |.|||.| ..|...:...||..||:.:|..|.:.|||||||.:.|:..|::|
Zfish    47 KSKRPKTVPVK--VLLLDGS-AYESGVEKLCKGQVLLDMVCEHLNLLEKDYFGLSFSDTECQKNW 108

  Fly    68 LDLSKSIIKQCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAAL 131
            ||.||.|.||.: :.|..||..|||||.||.:|..: .|..|..||:.|:..|||.||....|.|
Zfish   109 LDPSKEIKKQIR-VGPWHFSFAVKFYPPDPSQLIEDITRYYLCLQLREDILSGRLPCSFVTHALL 172

  Fly   132 GALIVQEELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARG 196
            |:..:|.|||||:.:.|...|::....|..||..||::::|||:... |.:.:.|...||..|:.
Zfish   173 GSYAIQAELGDYDPEEHGPDYINEFRFAPNQTRELEERVMELHRTYR-GMSPAEAEINFLENAKK 236

  Fly   197 LETYGIDPHPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDAS 261
            |..||:|.|..||..|....:|:..:|:..:....|...|.|.:|.||:::...|  ::......
Zfish   237 LSMYGVDLHHAKDSEGIDIMLGVCASGLLIYRDRLRINRFAWPKILKISYKRSNF--YIKIRPGE 299

  Fly   262 REPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTEREI 326
            .|..:.|:|||.|...|.:.||:..||...||.|.:.:...    .||...|:||||:|||:.:
Zfish   300 YEQFESTIGFKLPNHRASKRLWKVCIEHHTFFRLVSPEPPP----KGFLVIGSKFRYSGRTQAQ- 359

  Fly   327 LTENINALREQ---KNNSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEPLGYGMPNGHF 388
             :...:||.::   :...:.|:|...|......|..||    ....|.:.|.|||:. .:|....
Zfish   360 -SRQASALIDRPAPQFERSISRRYLLSRSIDGESALGD----TMDRLSQHTSSEPVP-SLPRDEL 418

  Fly   389 YGHDHGMSDANGGIQISSLEPVC-----------EEARLRSSNIDGVNYLASQIGGYAYRDSVEH 442
             ..|:             |||..           ||.||.|.:...              .:||.
Zfish   419 -DQDY-------------LEPSLDQDLDQDHEQEEEQRLESDSTPS--------------KTVEL 455

  Fly   443 SSTESGLTVNG-----------------YDHP----RKH----NEARQHGSYSPN--LYYGQS-- 478
            ...|:|..|:.                 .|.|    :||    ||.:: ....||  |.:.:.
Zfish   456 KREEAGSPVDSKTELDQDLTPRPKQEQFLDKPEDVLQKHQASINELKR-ALREPNSKLVHREKRL 519

  Fly   479 DGAVNSSSP--------------ADSFLHADPSTRKVKKFRKFHLLHAFVPSVIFVAFAMAGTAV 529
            .||.:.|:|              .|......|.::|.:|.|.        |.|..:|..
Zfish   520 SGASSGSTPEKKSASEESLLIEKQDGCQRDLPLSKKDEKSRS--------PRVASLATG------ 570

  Fly   530 FIMESESEAFEQ--------------------LRNSPEMLCLRYQYYQ----------------- 557
            |..|::....|:                    |||..:...|||.::|
Zfish   571 FNRETDDRVREKNIISVAKRTSTENILSPEKPLRNRAKSPALRYNHFQGINSLDEKAYDNGHSHD 635

  Fly   558 -PLKEFVLEKLG 568
             ||.|.|:...|
Zfish   636 RPLSENVIHTNG 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	79/192 (41%)
		FERM_N	16..80	CDD:286467	29/63 (46%)
		FERM_M	108..205	CDD:278785	37/96 (39%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	33/107 (31%)
		FA	308..349	CDD:285894	14/43 (33%)
si:dkey-178k16.1	XP_009294955.1	B41	56..245	CDD:214604	79/193 (41%)
		FERM_N	58..120	CDD:286467	29/62 (47%)
		FERM_M	138..245	CDD:278785	39/107 (36%)
		FERM_C_4_1_family	240..333	CDD:270005	29/94 (31%)
		FA	342..383	CDD:285894	14/42 (33%)
		SAB	482..522	CDD:282265	9/40 (23%)
		4_1_CTD	<1210..1261	CDD:283537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910