Protein Alignment Frmd5 and mylip

DIOPT Version :10

• Sequence 1: NP_609384.1
• Gene: Frmd5 / 34398
• FlyBaseID: FBgn0032225
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001017059.2
• Gene: mylip / 549813
• XenbaseID: XB-GENE-949814
• Length: 445
• Species: Xenopus tropicalis
• Alignment Length: 471
• Identity: 129/471 - (27%)
• Similarity: 189/471 - (40%)
• Gaps: 101/471 - (21%)

  Fly    21 DSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQCKEMDPLL 85
            |:.|:|.|......|...|..:|..|.|.|.|||||::..:..:..||:|...|.:|...:.|..
 Frog     9 DAVVMEVEVDAKANGEDCLNQVCKRLGIIEGDYFGLQFSGNKGENLWLNLRNRISQQMDGLAPFR 73

  Fly    86 FSLRVKFYPADPFRLTGNARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELGDYNEDVHVG 150
            ..|:|||:......|....|.|.:..:|.||..|||.||..:|..|.||:.|.|.|||:  |:..
 Frog    74 LKLKVKFFVEPHLILQEQTRHMFFLHIKEDLLAGRLQCSPAQAVELSALLAQMEYGDYS--VNTA 136

  Fly   151 SYVSSIELALR--QTECLEKKIIELHKKREPGQNLSLAMDE--FLGIARGLETYGIDPHPVKDHR 211
            :| |..:|..:  .|..|| .||..||..|   .||.|..|  ||.|...||.||::.|.|:|..
 Frog   137 TY-SLQDLCGKDIDTAALE-SIIAKHKSLE---GLSQASGEYQFLQIVSTLENYGVEWHSVRDAE 196

  Fly   212 GSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINF--------EGKMFIAHLSYTDASREPKKHT 268
            |.:..|||...|||..     .:.|  :.|::|.:        .||.  .:|:.|..|  .....
 Frog   197 GQKLIVGIGPEGISLC-----KEDF--SPINRITYPVIQMATQSGKN--VYLTITKES--GNSLV 250

  Fly   269 VGFKCPTGAACRYLWRCAIEQMLFF---TLPNS---QSAAVISG--GGFF-----SWGTKFRY-T 319
            :.||..:..|...|:|...|...|:   |:.|:   |.:..:.|  ..||     :.|.|:.: .
 Frog   251 LLFKVVSTRAASGLYRAITETHAFYRCDTVTNAVMMQYSRDLKGHLASFFLNDNINVGKKYVFDI 315

  Fly   320 GRTEREIL---------------------TENINALREQKNNSNSSKRKASSVPATPSSPQGDLA 363
            .||.:|:.                     :|..:.|:..::|.|.:..::.|...| .:.|..|.
 Frog   316 RRTSKEVYDHARRALYNAGIVDLVSGSGHSEPSSPLKTSESNMNCNSCESLSCQQT-KALQEKLR 379

  Fly   364 QIRYSSLPRSTMSEPLGYGM-PNGHFYGHDHGMSDANG-GIQISSLEPVCEEARLRSSNIDGVNY 426
            :::.:.|......|.:.... |.||       |....| ..|:.|. |||
 Frog   380 KLKEAMLCMLCCEEEINSAFCPCGH-------MVCCEGCATQLQSC-PVC--------------- 421

  Fly   427 LASQIGGYAYRDSVEH 442
                      |.||||
 Frog   422 ----------RASVEH 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frmd5	NP_609384.1	FERM_F1_FRMD3	12..93	CDD:340622	24/71 (34%)
		FERM_M	104..205	CDD:459788	42/104 (40%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	34/120 (28%)
		FA	308..350	CDD:462582	11/68 (16%)
mylip	NP_001017059.2	FERM_F1_MYLIP	1..81	CDD:340624	24/71 (34%)
		B41	5..190	CDD:214604	68/187 (36%)
		FERM_C_MYLIP_IDOL	185..295	CDD:270016	30/120 (25%)
		RING-HC_MYLIP	383..434	CDD:438186	17/78 (22%)