DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5022 and EPB41L4B

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_011517092.1	Gene:	EPB41L4B / 54566	HGNCID:	19818	Length:	941	Species:	Homo sapiens

Alignment Length:	516	Identity:	146/516 - (28%)
Similarity:	222/516 - (43%)	Gaps:	83/516 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQC 78
            |.|.|||.::| ..:.....||..|.:.:...|::.|.|||||:::||::..||||.:|.|.||.
Human    87 CRVFLLDGTEV-SVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIKKQM 150

  Fly    79 KEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELGD 142
            |.........|||:|.::|..|... .|.:...||:.|:..|:|.|....|..|.||.:|.|||:
Human   151 KIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGE 215

  Fly   143 YNEDVHVGSYVSSIELALRQTECLEKKIIELHKK---REPGQNLSLAMDEFLGIARGLETYGIDP 204
            .....|....||.......|||.:|..|.:..|:   :.|.|    |...:|..|:.||.||:|.
Human   216 CELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQ----AELSYLNKAKWLEMYGVDM 276

  Fly   205 HPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINF-EGKMFIAHLSYTDASREPKKHT 268
            |.|:...|.:..:|:..|||..|....:...|.|.:|.|::| :.|:.:..:...|..|| ::||
Human   277 HVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGRE-QEHT 340

  Fly   269 VGFKCPTGAACRYLWRCAIEQMLFFTL---PNSQSAAVISGGGFFSWGTKFRYTGRTEREILTEN 330
            ..|:..:...|::||:||:|...||.|   .||:|    :...|...|::||::||||.:.
Human   341 FVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS----NRSDFIRLGSRFRFSGRTEYQA---- 397

  Fly   331 INALREQKNNSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTM--SEPL------GYGMPNGH 387
                     ...|..|:.|:....||.        ||.|...||.  |.|:      ....|..|
Human   398 ---------THGSRLRRTSTFERKPSK--------RYPSRRHSTFKASNPVIAAQLCSKTNPEVH 445

  Fly   388 FY--------------GHDHGMSDANGGIQISSLEPVCEEARLRSSNIDGVNYLASQIGGYAYRD 438
            .|              .|.|   ..|....:.|  ||.       |:.|.:.:...:.||..:
Human   446 NYQPQYHPNIHPSQPRWHPH---SPNVSYPLPS--PVL-------SSSDRLPFGIEENGGTPF-- 496

  Fly   439 SVEHSSTESGLTVNGYDHPRKHNEARQHGSYSPNLYYGQSDGAVNS-SSPADSFLHADPST 498
                .:..||...:.:.|..:|   :.|.:||.:|.....:|.:.| :|.:.|.....|.|
Human   497 ----LTAASGRHHHQHQHQHQH---QHHSNYSLSLTLENKEGPLRSPNSSSKSLTKLSPGT 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	67/194 (35%)
		FERM_N	16..80	CDD:286467	25/63 (40%)
		FERM_M	108..205	CDD:278785	33/99 (33%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	35/108 (32%)
		FA	308..349	CDD:285894	10/40 (25%)
EPB41L4B	XP_011517092.1	B41	87..277	CDD:214604	67/194 (35%)
		FERM_N	89..151	CDD:286467	25/62 (40%)
		FERM_M	170..277	CDD:278785	35/110 (32%)
		FERM_C_NBL4_NBL5	273..366	CDD:270007	29/93 (31%)
		FA	379..419	CDD:285894	15/60 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151639
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740