DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5022 and Epb41l4b

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_038966499.1	Gene:	Epb41l4b / 500464	RGDID:	1562988	Length:	897	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	157/558 - (28%)
Similarity:	242/558 - (43%)	Gaps:	100/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQC 78
            |.|.|||.::| ..:.....||..|.:.:...|::.|.|||||:::||::..||||.||.|.||.
  Rat    87 CRVFLLDGTEV-SVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVTHWLDHSKPIKKQM 150

  Fly    79 KEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELGD 142
            |.........|||:|.::|..|... .|.:...||:.|:..|:|.|....|..|.||.:|.|||:
  Rat   151 KVGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGE 215

  Fly   143 YNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGIDPHPV 207
            .....|....||.......|||.:|..|.:..|:.. |::.:.|...:|..|:.||.||:|.|.|
  Rat   216 CELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKEYR-GKSPAQAELSYLNKAKWLEMYGVDMHVV 279

  Fly   208 KDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINF-EGKMFIAHLSYTDASREPKKHTVGF 271
            :...|.:..:|:..|||..|....:...|.|.:|.|::| :.|:.:..:...|..|| ::||..|
  Rat   280 RGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGRE-QEHTFVF 343

  Fly   272 KCPTGAACRYLWRCAIEQMLFFTL---PNSQSAAVISGGGFFSWGTKFRYTGRTEREILTENINA 333
            :..:...|::||:||:|...||.|   .||:||.    ..|...|::||::||||.: .|.....
  Rat   344 RLDSARTCKHLWKCAVEHHAFFRLRTPSNSKSAR----SDFIRLGSRFRFSGRTEYQ-ATHGSRL 403

  Fly   334 LR----EQKNNSNSSKRKASSVPAT----------------------------PSSP--QGDLAQ 364
            .|    |:|.:.....|:.|:..|:                            ||.|  :.....
  Rat   404 RRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSKTNPEVHNYQPQFHPNVHPSQPRWRPHSPN 468

  Fly   365 IRYSSLPRSTMS--EPLGYGM-PNG-----------HFYGHDHGMSDANGGIQISSLEPVCEEAR 415
            :.| .||...:|  |.|.:|: .||           |.:.|.|   .:|.|:.: :||.  :||.
  Rat   469 VSY-PLPSPALSPTERLPFGLEENGGTPFAPKASGRHHHQHQH---HSNYGLSL-TLEN--KEAP 526

  Fly   416 LRSSNIDGVNYLASQIGGYAYRDSVEHSSTESGLTVNGYDHPRKHNEARQHGSYSPNLYYGQSDG 480
            |||.|                        :...||......|..::||..|      |...:.|
  Rat   527 LRSPN------------------------SSKALTKLSPGAPALYSEAAAH------LKKLELD- 560

  Fly   481 AVNSSSPADSFLHADPSTRKVKKFRKFHLLHAFVPSVI 518
            .|.::.|..: ||.:.:..:.||..:..|....:||.:
  Rat   561 TVKAAGPWPA-LHININKAEEKKVSEKTLQTPLLPSPV 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	67/191 (35%)
		FERM_N	16..80	CDD:286467	26/63 (41%)
		FERM_M	108..205	CDD:278785	32/96 (33%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	35/108 (32%)
		FA	308..349	CDD:285894	13/44 (30%)
Epb41l4b	XP_038966499.1	B41	87..277	CDD:214604	67/191 (35%)
		FERM_C_NBL4_NBL5	273..366	CDD:270007	29/93 (31%)
		FA	379..420	CDD:400882	12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345132
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840