Protein Alignment Frmd5 and epb41l4a

DIOPT Version :10

• Sequence 1: NP_609384.1
• Gene: Frmd5 / 34398
• FlyBaseID: FBgn0032225
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001006910.1
• Gene: epb41l4a / 448757
• XenbaseID: XB-GENE-953979
• Length: 678
• Species: Xenopus tropicalis
• Alignment Length: 638
• Identity: 166/638 - (26%)
• Similarity: 256/638 - (40%)
• Gaps: 151/638 - (23%)

  Fly    12 YKCTVRLLDDSDV-LECEFQPFH---KGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSK 72
            :.|.|.|||:|.: |.|:.|...   ||..:|:|:...|.:.|.|||||||.|.:.|.:|||..|
 Frog    11 FYCEVLLLDESKLPLTCQQQGVKKSTKGSVVLDYVFRHLNLVEIDYFGLRYCDRNHQTYWLDPMK 75

  Fly    73 SIIKQCKEM----DPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALG 132
            : |.:.:::    .|......||||..||.:|... .|...:.|:|:|:..|||.|....||.||
 Frog    76 T-ISEHRDLISTGPPYTLYFGVKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPFNIAAQLG 139

  Fly   133 ALIVQEELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGL 197
            |..:|.|||||:...||..|||.......|.|.||:.|.::||.. .||..::|...:||:|:.|
 Frog   140 AYAIQSELGDYDPFKHVTGYVSEYRFVPDQKEDLEEAIEKIHKTL-MGQVPAVAESNYLGVAKSL 203

  Fly   198 ETYGIDPHPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASR 262
            |.||:|.|||.....|:.::|:...|:..:...|:...:.|..|.|::|:...|...:...|.:
 Frog   204 EMYGVDLHPVYGENNSEYFLGLTPVGLFVYKNKKQVGKYYWPRITKLHFKETQFEVRVLGKDCT- 267

  Fly   263 EPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAV---ISGGGFFSWGTKFRYTGRT-- 322
               :.:..|:.....:|:.||:|.:|...||.:|.:.|:.:   :|..|  |.|::.||:|||
 Frog   268 ---ETSFFFETRNKVSCKSLWKCCVEHHTFFRIPENDSSTLSRKLSKLG--SLGSRHRYSGRTAY 327

  Fly   323 --------------------------EREILTE--NINALREQKNNSNSSKRKASSVPATPS--- 356
                                      :|..||:  ..|.:.:...|.....::.::....||
 Frog   328 QMSRDLSIQLPRPDQRVERSRSKTYPKRAALTQQPGSNNIEQPTTNMEQGDKEGTTKFIAPSPVK 392

  Fly   357 ---------SPQGDLAQIRYSSLPRSTMSEPLG-YGMPNGH---------FYGHDHGMSDANGGI 402
                     ||....::|   |.|......|.| |..||..         .:.:..|..:..|
 Frog   393 SSKKAKRDTSPDTQKSKI---SAPWEENGTPSGLYNSPNDRNKSPKFPTPRHRNQSGSDNETG-- 452

  Fly   403 QISSLEPV-----C--EEARLRSSNIDGVNYLASQIGGYAYRDSVEHSSTESGLTVN--GYDHPR 458
                 :||     |  :||.|:..                 |.|....:|.||....  ..:|.:
 Frog   453 -----QPVRRKGQCSGDEADLKHR-----------------RRSRSRCNTSSGSESENCNREHRK 495

  Fly   459 KHNEARQHGSY--------------------SPNLYYGQSDGAVNSSSP-----ADSFLH----- 493
            |.|..||....                    .||  |.:|.....|.||     .:.:.|
 Frog   496 KRNRLRQENDMVDSAPQWEAVLRRQKEKNQADPN--YRRSRHRSRSRSPDVQAKEELWKHIQKEL 558

  Fly   494 ADPSTRKVKKFRKFHLLHAFVPSVIFVAFAMAGTAVFIMESES-EAFEQLRNS 545
            .|||....::.::       :|   ::.....|..:.|..|.| .:|.|.|.|
 Frog   559 VDPSGLSEEQLKE-------IP---YMKIETQGDPIRIRHSHSPRSFRQYRRS 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frmd5	NP_609384.1	FERM_F1_FRMD3	12..93	CDD:340622	32/88 (36%)
		FERM_M	104..205	CDD:459788	42/100 (42%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	29/107 (27%)
		FA	308..350	CDD:462582	13/71 (18%)
epb41l4a	NP_001006910.1	B41	13..211	CDD:214604	79/199 (40%)
		FERM_C_NBL4_NBL5	207..296	CDD:270007	22/92 (24%)
		FA	311..355	CDD:462582	8/45 (18%)
		Macoilin	<313..>523	CDD:462859	43/238 (18%)