DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5022 and epb41l3a

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_021325820.1	Gene:	epb41l3a / 445478	ZFINID:	ZDB-GENE-040822-8	Length:	1177	Species:	Danio rerio

Alignment Length:	414	Identity:	130/414 - (31%)
Similarity:	191/414 - (46%)	Gaps:	59/414 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SKNEGNIVYKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWL 68
            ||...|:  :|.:.|||.|| ..|..:...||..|.:.:|..|.:.||||||:.:.|...|::||
Zfish    84 SKKPKNM--QCKITLLDGSD-YTCVVEKRDKGQVLFDKVCEHLNLLEKDYFGITFRDVENQKNWL 145

  Fly    69 DLSKSIIKQCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALG 132
            |.:|.:.||.:.: ...||..|||||.:|..|:.: .|..|..||:.|:..|||.||......||
Zfish   146 DPAKDMKKQIRGV-AWNFSFNVKFYPPEPALLSEDITRYYLCLQLRDDISSGRLPCSFATHTVLG 209

  Fly   133 ALIVQEELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGL 197
            :..||.||||::.:.....|.|....|.:||:.:|:|||:|||..: |...:.|...||...:.|
Zfish   210 SYTVQSELGDHDPEECGSEYTSEFRFAPQQTKEMEEKIIDLHKNYK-GMTPAEAEMHFLENVKKL 273

  Fly   198 ETYGIDPHPVK---------------DHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFE 247
            ..||:|.|..|               |..|.:..:|:.::|:..:....|...|.|.::.||:::
Zfish   274 SMYGVDLHHAKLIGRFFHCFSPAKGEDSEGVEIMLGVCSSGLLIYRDRLRINRFAWPKVLKISYK 338

  Fly   248 GKMFIAHLSYTDASREPKKHTVGFKCPTGAACRYLWRCAIEQMLFF--TLPNSQSAAVISGGGFF 310
            ...|  ::.......|..:.|:|||.|...|.:.||:..:|...||  .||.:....      |.
Zfish   339 RNNF--YIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLVLPETPPKK------FL 395

  Fly   311 SWGTKFRYTGRTEREILTENINALREQKNNSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTM 375
            :.|:||||:|||:                   :..|:|||....|:      ...:.||..|.||
Zfish   396 TLGSKFRYSGRTQ-------------------AQTRRASSQIVRPA------PYFQRSSSKRYTM 435

  Fly   376 SEPLGYGMPNGHFYGHDHG--MSD 397
            |..|. |......||...|  |||
Zfish   436 SRSLD-GEMGTALYGAAKGIAMSD 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	73/192 (38%)
		FERM_N	16..80	CDD:286467	25/63 (40%)
		FERM_M	108..205	CDD:278785	37/96 (39%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	31/124 (25%)
		FA	308..349	CDD:285894	10/40 (25%)
epb41l3a	XP_021325820.1	B41	92..281	CDD:214604	73/191 (38%)
		FERM_C_4_1_family	276..384	CDD:270005	27/109 (25%)
		FA	393..434	CDD:312314	17/71 (24%)
		SAB	564..610	CDD:309500
		DNA_pol3_delta2	<604..>780	CDD:331068
		4_1_CTD	1064..1169	CDD:310467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740