DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5022 and epb41l5

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_956383.1	Gene:	epb41l5 / 368449	ZFINID:	ZDB-GENE-030616-450	Length:	772	Species:	Danio rerio

Alignment Length:	397	Identity:	134/397 - (33%)
Similarity:	197/397 - (49%)	Gaps:	45/397 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VYKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSII 75
            :..|.|.|||.:|| ..:.....||..|.|.:...|::.||||||||::||::..||||::|||.
Zfish    42 IITCRVSLLDGTDV-SVDLPKKAKGAELFEQIMYHLDVVEKDYFGLRFMDSAQVPHWLDVTKSIK 105

  Fly    76 KQCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEE 139
            ||.|...|....:|||||.::|..|... .|.:...|||:|:..|:|.|.......|.:..:|.|
Zfish   106 KQVKIGPPYCLHMRVKFYSSEPNNLHEELTRYLFVLQLKQDILSGKLECPFDTTVELASYALQAE 170

  Fly   140 LGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGIDP 204
            ||||:...|....||.......|||.:|..|....|:.. ||..:.|...:|..|:.||.||:|.
Zfish   171 LGDYDPAEHGLDLVSEFRFIPNQTEDMEVAIYNAWKECR-GQTPAQAEINYLNKAKWLEMYGVDM 234

  Fly   205 HPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEG-KMFIA-------HLSYTDAS 261
            |.||...|::..:|:..||:..|....:...|.|.:|.:::|:. |:.:.       .:..|:..
Zfish   235 HMVKARDGNEYSLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKCKLTLVVVEDDEQVMQETEEG 299

  Fly   262 REPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTL--PNSQSAAVISGGGFFSWGTKFRYTGRTER 324
            :| ::||..|:.....||::||:||:|...||.|  |..:|:|   ..||...|::|||:|:||
Zfish   300 KE-QEHTFVFRMDHPKACKHLWKCAVEHHAFFRLRGPVQKSSA---RSGFIRMGSRFRYSGKTE- 359

  Fly   325 EILTENINALREQKNNSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEPLGYGMPNGHFY 389
                       .|...:|.::|.| |....||.        |||   |.||   |..| ||....
Zfish   360 -----------YQTTKANKARRSA-SFERRPSR--------RYS---RRTM---LNRG-PNKSSD 397

  Fly   390 GHDHGMS 396
            .|::|:|
Zfish   398 NHNNGVS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	74/192 (39%)
		FERM_N	16..80	CDD:286467	30/63 (48%)
		FERM_M	108..205	CDD:278785	33/96 (34%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	34/115 (30%)
		FA	308..349	CDD:285894	12/40 (30%)
epb41l5	NP_956383.1	B41	44..235	CDD:214604	74/192 (39%)
		FERM_N	47..109	CDD:286467	30/62 (48%)
		FERM_B-lobe	135..227	CDD:271216	29/92 (32%)
		FERM_C_NBL4_NBL5	231..331	CDD:270007	28/100 (28%)
		FA	344..>375	CDD:285894	14/43 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840